SciELO - Scientific Electronic Library Online

vol.55 issue2 author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Revista de la Facultad de Medicina (México)

On-line version ISSN 2448-4865Print version ISSN 0026-1742


GARCIA GONZALEZ, Rafael; BASILIO HERNANDEZ, David  and  HERNANDEZ RAMIREZ, Aurora. Parvovirus B19: Laboratory diagnosis. Rev. Fac. Med. (Méx.) [online]. 2012, vol.55, n.2, pp.4-10. ISSN 2448-4865.

Parvovirus B19 (B19) is the only known human pathogenic parvovirus. The spectrum of illness to which B19 is associated includes a wide range of diseases: erythema infectiosum, thrombocytopenia or granulocytopenia, aplastic crisis or hemolytic anemia in immunocompromised patients. The laboratory diagnosis of Parvovirus B19 infection is primarily confirmed by the detection of IgM antiviral antibodies using the ELISA technique, which is directed against both conformational and linear epitopes of VP1 and VP2 capsid. When IgM response declines, an IgG immune-response against structural proteins VP1 and VP2 becomes prominent and can detected by immunofluorescence, ELISA and Western blot. Polymerase chain reaction is now used as a routine analysis as well as complement or alternative to serology.

Keywords : Human parvovirus B19; diagnosis; IgM; IgG; ELISA; PCR.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License