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Revista de la Facultad de Medicina (México)

On-line version ISSN 2448-4865Print version ISSN 0026-1742


CARRILLO ESPER, Raúl; GARNICA ESCAMILLA, Marco Antonio; ROCHA RODRIGUEZ, María Guadalupe  and  CARRILLO CORDOVA, Carlos Alberto. Serotonin syndrome. Rev. Fac. Med. (Méx.) [online]. 2011, vol.54, n.2, pp.46-53. ISSN 2448-4865.

The serotonin syndrome (SS) is characterized by a spectrum of signs characterized by autonomic dysfunction, neuromuscular impairment, and alterations in mental status. The diagnosis of the serotonin syndrome is clinical and by laboratory evaluation. Treatment is with active cooling and benzodiazepines to control agitation, and intubation, especially in patients with severe hyperthermia and delirium. The mainstay of pharmacologic intervention is cyproheptadine, a centrally acting H1-antagonist, with a prominent peripheral 5-HT2A antagonism. The drug is only available orally, and if the patient is unable to swallow, the drug should be administered nasogastrically. The objective of this paper is report a case of Serotonin Syndrome and review the literature related to this disease.

Keywords : serotonin syndrome; serotonine; cyproheptadine; olanzapine.

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