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Gaceta médica de México
On-line version ISSN 2696-1288Print version ISSN 0016-3813
Abstract
GUTIERREZ-GARCIA, Christopher A.; GUTIERREZ-JIMENEZ, Martín R.; SANDOVAL-MUNIZ, Roberto de J. and BAPTISTA-ROSAS, Raúl C.. Single nucleotide variants of the SLC2A2 gene in Mexican-origin population. Gac. Méd. Méx [online]. 2025, vol.161, n.1, pp.108-115. Epub May 16, 2025. ISSN 2696-1288. https://doi.org/10.24875/gmm.24000293.
Background:
Diabetes, which is caused by environmental and genetic factors, has a high global prevalence (10.5%). Some single nucleotide variants (SNVs) modify the activity of glucose transporters such as GLUT2, which plays a significant role in insulin secretion and glucose metabolism.
Objective:
To analyze the SNVs associated with type 2 diabetes (T2D) in the Mexican population.
Material and methods:
Reference databases for SNVs registered for SLC2A2 gen associated with T2D in the Mexican population.
Results:
83 SNVs were analyzed, identifying 3 relevant variants in Mexican population associated with T2D: rs5404, rs5406 and rs5398, a pathogenic variant with RM >1.0 and p value < 0.05.
Conclusions:
Detailed genetic analysis and mapping coupled with functional studies are needed to identify the mechanism by which GLUT2 variants influence diabetes development.
Keywords : Type 2 Diabetes mellitus; Mexican people; Single nucleotide polymorphisms; Glucose transporter type 2; Single nucleotide variants.
