Abstract

TORRES-FLORES, Alejandro; WONG-BAEZA, Isabel  and  LOPEZ-MACIAS, Constantino. Contribution of memory T cells to the generation of long-lasting immunity against COVID-19. Gac. Méd. Méx [online]. 2024, vol.160, n.2, pp.135-143.  Epub Oct 25, 2024. ISSN 2696-1288.  https://doi.org/10.24875/gmm.23000451.

Humans are exposed every day to innumerable external stimuli, both environmental and microbial. Immunological memory recalls each specific stimulus and mounts a secondary response that is faster and of a larger magnitude than the primary response; this process constitutes the basis for vaccine development. The COVID-19 pandemic offers a unique opportunity to study the development of immune memory against an emergent microorganism. Memory T cells have an important role in the resolution of COVID-19, and they are key pillars of immunological memory. In this review, we summarize the main findings regarding anti-SARS-CoV-2 memory T cells after infection, after vaccination, and after the combination of these two events ("hybrid immunity"), and analyze how these cells can contribute to long-term protection against the infection with SARS-CoV-2 variants.

Keywords : T cells; Immunological memory; SARS-CoV-2.

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