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Gaceta médica de México

On-line version ISSN 2696-1288Print version ISSN 0016-3813


ALBARRAN-SANCHEZ, Alejandra et al. Association of neutrophil-to-lymphocyte and lymphocyte-to-C-reactive protein ratios with COVID-19-related mortality. Gac. Méd. Méx [online]. 2020, vol.156, n.6, pp.563-568.  Epub May 27, 2021. ISSN 2696-1288.


Neutrophil-to-lymphocyte (NLR) and lymphocyte-to-C-reactive protein (LCR) ratios are used to predict severity and mortality in various infections.


To establish the best NLR and LCR cutoff point to predict mortality in patients hospitalized for COVID-19 in Mexico.


Analytical cross-sectional study of patients hospitalized for severe COVID-19 in a specialty hospital.


Out of 242 analyzed patients, 34 % died. The deceased subjects were older (62 vs. 51 years; p < 0.001), had a higher prevalence of > 10 years with systemic arterial hypertension (59.4 vs. 45.1 %, p = 0.022), as well as a higher NLR (17.66 vs. 8.31, p < 0.001) and lower LCR (0.03 vs. 0.06, p < 0.002] with regard to those who survived. The cutoff points to predict mortality were NLR > 12 and LCR < 0.03. The combination of NLR/LCR had a sensitivity of 80 %, specificity of 74 %, positive predictive value of 46.15 %, negative predictive value of 93.02 % and an odds ratio of 11.429 to predict mortality.


NLR > 12 and LCR < 0.03 are useful biomarkers to evaluate the risk of mortality in Mexican patients with severe COVID- 19.

Keywords : COVID-19; In-hospital mortality; Neutrophil-to-lymphocyte ratio.

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