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Gaceta médica de México

On-line version ISSN 2696-1288Print version ISSN 0016-3813


SANTIBANEZ-VELAZQUEZ, Martín; MEDINA-GARCIA, Gabriela  and  OCHARAN-HERNANDEZ, María E.. Association of independent risk factors with post-extubation failure in patients undergoing mechanical ventilation weaning. Gac. Méd. Méx [online]. 2020, vol.156, n.6, pp.549-555.  Epub May 27, 2021. ISSN 2696-1288.


Even with an adequate mechanical ventilation weaning (MVW) protocol, the procedure fails in 15 to 30 % of cases.


To assess the association between independent risk factors (IRFs) and post-extubation failure in patients undergoing MVW in an intensive care unit.


Longitudinal, prospective, analytical cohort study in patients on mechanical ventilation for more than 24 hours and who were extubated. Pre-extubation reports of hemoglobin, albumin, phosphorus, waist-hip ratio and SOFA score were obtained. Extubation failure was defined as resumption of mechanical ventilation within 48 hours or less.


123 patients were extubated, out of whom 74 were males (60 %); average age was 50 ± 18 years. Extubation failure occurred in 37 (30 %). Hypoalbuminemia was associated as an independent risk factor in 29 (23.8 %, RR = 1.43, 95 % CI = 1.11-1.85) and hypophosphatemia was in 18 (14.6 %, RR = 2.98, 95 % CI = 1.66-5.35); two or more IRFs were observed in 22.7 % (RR = 1.51, 95 % CI = 1.14-2.00).


Identifying independent risk factors prior to MVW can help reduce the risk of extubation failure and associated morbidity and mortality.

Keywords : Weaning; Mechanical ventilation; Extubation failure; Independent risk factors.

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