SciELO - Scientific Electronic Library Online

vol.155 issue5Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL indexRole of genetic variability in Mendelian and multifactorial diseases author indexsubject indexsearch form
Home Pagealphabetic serial listing  

Services on Demand




Related links

  • Have no similar articlesSimilars in SciELO


Gaceta médica de México

On-line version ISSN 2696-1288Print version ISSN 0016-3813


HERNANDEZ-DA MOTA, Sergio et al. Classification of fundus autofluorescence abnormal patterns in diabetic macular edema. Gac. Méd. Méx [online]. 2019, vol.155, n.5, pp.458-462.  Epub July 01, 2021. ISSN 2696-1288.


Patients with diabetic macular edema can develop fundus autofluorescence alterations; thus far, these alterations have been more widely studied with scanning or confocal laser systems.


To describe and classify fundus autofluorescence abnormal patterns in patients with diabetic macular edema using the fundus autofluorescence system with a flash camera.


Observational, retrospective, cross-sectional, descriptive study. Fundus autofluorescence digital images of non-comparative cases with untreated diabetic macular edema, obtained and stored with a flash camera system, were assessed. Inter-observer variability was evaluated.


37 eyes of 20 patients were included. Lens opacity was the most common cause of inadequate image quality. Five different fundus autofluorescence patterns were observed: decreased (13%), normal (40%), single-spot hyper-autofluorescent (17 %), multiple-spot hyper-autofluorescent (22 %) and plaque-like hyper-autofluorescent (8 %). The kappa coefficient was 0.906 (p = 0.000).


Different fundus autofluorescence phenotypic patterns are observed with flash camera systems in patients with diabetic macular edema. A more accurate phenotypic classification could help establish prognostic factors for visual loss or for the design of clinical trials for diabetic macular edema.

Keywords : Fundus autofluorescence; Diabetic macular edema; Diabetic retinopathy.

        · text in English     · English ( pdf )