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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
HERNANDEZ-RIVERA, Juan Carlos H. et al. Alelos HLA más comunes y asociados con riesgo o protección en enfermedad renal crónica de etiología no determinada. Gac. Méd. Méx [online]. 2019, vol.155, n.3, 07. Epub 01-Jul-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.19005033.
Introduction:
Chronic kidney disease accounts for part of overall health expenditure; a potential etiology is related to variations, absence or presence of some human leukocyte antigen (HLA) alleles.
Method:
An analysis of HLA reports of 1965 kidney recipients with no determined etiology, and 1361 kidney donors was performed. It was carried out with Luminex based in cell flow fluorometry for the A, B, DRB1 and DQA loci. An analysis was performed with contingency tables in order to determine the odds ratio (OR) and confidence intervals (CI). Quantitative analysis was also carried out.
Results:
Of the 101 alleles found, 13 showed association, 7 with risk for chronic kidney disease, with the most significant being HLA-DR17 with an OR of 3.91 (95 % CI = 2.96-5.17) and the one with the highest significance for protection being HLA-DR9, with an OR of 0.043 (95 % CI = 0.005-0.3224).
Conclusions:
It is necessary to understand that kidney diseases can be associated with yet unknown immune processes, where the association of the absence or presence of any allele should be known.
Palabras llave : Chronic kidney disease; Human leukocyte antigen; Kidney recipients; Alleles.