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Gaceta médica de México
versión On-line ISSN 2696-1288versión impresa ISSN 0016-3813
Resumen
BORJAS-GARCIA, Jaime Antonio; LUGO-VEGA, Everardo; LLAMAZARES-AZUARA, Lilia María de Guadalupe y MARTINEZ-MARTINEZ, Marco Ulises. Performance of the equations to estimate the glomerular filtration rate in Mexican patients receiving kidney transplantation. Gac. Méd. Méx [online]. 2019, vol.155, n.3, 03. Epub 01-Jul-2021. ISSN 2696-1288. https://doi.org/10.24875/gmm.m18004335.
Introduction:
The management of kidney transplant recipients requires glomerular filtration rate (GFR) monitoring, which is an indicator of graft primary function and patient survival.
Objective:
To evaluate the performance of different creatinine or cystatin-based formulas in the estimation of glomerular filtration rate in Mexican patients receiving kidney transplantation.
Method:
30 transplant recipients were included, in whom the glomerular filtration rate was measured by means of iothalamate, and was also calculated using seven equations based on cystatin or creatinine.
Results:
The formula with the best performance was the one proposed by the chronic kidney disease epidemiology collaboration (CKD-EPI), with a bias of −2.4 mL/min/1.73 m2: and an accuracy of 9.6; 96.7 % of patients were within 30 % of the measured GFR. The second best formula was the modification of diet in renal disease (MDRD) equation. Cystatin-based equations showed a poor performance.
Conclusions:
Our study suggests that, in Mexican patients receiving kidney transplantations, the best equations to estimate GFR are the CKD-EPI and MDRD equations.
Palabras llave : Glomerular filtration rate; Kidney transplantation; Kidney function; Chronic Kidney Disease Epidemiology Collaboration Modification of Diet in Renal Disease; Creatinine clearance.
