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Medicina crítica (Colegio Mexicano de Medicina Crítica)
versión impresa ISSN 2448-8909
Resumen
GALLARDO RAMIREZ, Jessica Juve; HERNANDEZ PACHECO, José Antonio; NARES TORICES, Miguel Ángel y VARGAS TRUJILLO, Samuel. Association of Soluble fms-like tyrosine kinase 1/Placental Growing Factor + Platelet count/mean platelet volume ratios as a predictor of adverse outcomes in preeclampsia. Med. crít. (Col. Mex. Med. Crít.) [online]. 2024, vol.38, n.7, pp.568-571. Epub 29-Sep-2025. ISSN 2448-8909. https://doi.org/10.35366/119528.
Introduction:
the use of detection of the ratio of imbalance between proangiogenic/antiangiogenic factors (sFlt-1/PlGF) in maternal blood has been a useful tool for the diagnosis of preeclampsia. Platelet aggregation also plays a crucial role in the development of the disease, platelet parameters such as the ratio platelet count/mean platelet volume (PC/MPV) have the advantage of being easy, fast and low cost in the detection of preeclampsia, if we add these ratios the ability to predict preeclampsia can be improved, however there is no evidence on the prognosis and prediction of adverse outcomes.
Objective:
to evaluate the association of soluble vascular endothelial growth factor receptor 1/placental growth factor + Platelet Count/Mean Platelet Volume (sFlt-1/PlGF + PC/MPV) ratios as a predictor of adverse outcomes in preeclampsia.
Material and methods:
descriptive, retrospective, analytical, cross-sectional, single-center study, where information was obtained from electronic records of patients diagnosed with preeclampsia who had serum measurements of sFlt-1, PlGF, PC and MPV. Statistical analysis of the association of the result of the sum of sFlt-1/PlGF + PC/MPV ratios and adverse maternal outcomes was performed taking into account Acute Kidney Injury, Eclampsia, Neurological Complications, Pulmonary Edema, HELLP, Liver Injury, ICU stay days, use of renal function replacement therapy, Obito and Maternal Death. The cut-off point was calculated and the receiver operating characteristic (ROC) curve was used to calculate sensitivity and specificity.
Results:
57 records were analyzed, with ages ranging from 15 to 43 years with a mean of 32 years, finding an area under the curve (AUC) of 0.768 (95% CI: 0.63-0.90) for the cut-off point of 62.4, sensitivity of 97.2% and specificity of 86.7%, P 0.001 and an estimated risk of 4.7 (95% CI: 0.40-56.1).
Conclusions:
the addition of the sFlt 1/PlGF + PC/MPV ratios does not predict adverse events related to complications from preeclampsia.
Palabras llave : preeclampsia; sFlt1; PlGF; angiogenic; mean platelet volume.
