Resumen

FLORES-RAMIREZ, Valeria Estefanía; ARANDA-HERRERA, Benjamín; GUZMAN-ROCHA, Dulce  y  GARCIA-CONTRERAS, René. Cytotoxic effect of MgO and ZnO nanoparticles on oral cancer cell culture: nanocarriers for chemotherapeutic treatments. Mundo nano [online]. 2025, vol.18, n.35, e69819.  Epub 01-Ago-2025. ISSN 2448-5691.  https://doi.org/10.22201/ceiich.24485691e.2025.35.69819.

Oral cancer, one of the main causes of mortality worldwide, is commonly treated with chemoradiotherapy. However, these therapies have limitations. Recent research focuses on the use of nanoparticles like MgO and ZnO to improve treatment and to evaluate the nanocytotoxic effect of MgO and ZnO nanoparticles on lymphoblastic-origin cancer cells. Lymphoblastic-origin primary culture cancer cells characterized by immunohistochemistry (IHC) were used, and nanocytotoxicity tests were performed using MgO and ZnO nanoparticles at concentrations ranging from 0 to 1.33 mg/mL. Cell viability was measured using the MTT assay by UV-Vis. Statistical analysis was carried out using the t-student test and ANOVA (p ≤ 0.05). Histopathological analyses confirmed the presence of oral lymphoblastic neoplastic lesions with specific characteristics, positive for cyclin D1 and negative for CD3. The results showed slight toxicity at the maximum dose for both nanoparticles (80% for MgO and 94% for ZnO) with statistically significant dose-dependent reduction (p < 0.05). MgO and ZnO nanoparticles have a slight cytotoxic effect on lymphoblastic cancer cells, so it is necessary to develop more effective chemotherapeutic treatments based on nanoparticles in combination with antitumor agents to confirm this hypothesis.

Palabras llave : oral cancer; nanoparticles; anti-tumor; dose-response.

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