Resumen

YU LIN, Hu; XIANG, Liu  y  MING, Lu. Synthesis and Biological Activity of Novel 6-Substituted Purine Derivatives. J. Mex. Chem. Soc [online]. 2010, vol.54, n.2, pp.74-78. ISSN 1870-249X.

A series of 6-substituted purines were synthesized from commercially available 2-amino-6-chloropurine with appropriate reagents, and nine new compounds 7, 8, and 11-17 have been discovered. The compounds synthesized were identified by elemental analysis, ¹H NMR, as well as mass spectral data. All the title compounds were screened for their antifungal activities, under the method of the disc diffusion, using three species of fungi - Bacillus subtillis, Aspergillus niger, and Candida tropicalis- and some of the compounds showed promising activities.

Palabras llave : 6-Substituted purines; 2-amino-6-chloropurine; Synthesis; Antifungal Activity.

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