<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2696-130X</journal-id>
<journal-title><![CDATA[Revista mexicana de angiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. angiol.]]></abbrev-journal-title>
<issn>2696-130X</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Angiología, Cirugía Vascular y Endovascular A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2696-130X2024000200065</article-id>
<article-id pub-id-type="doi">10.24875/rma.24000018</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fisiopatología de la vasculopatía digital en pacientes con esclerosis sistémica. Revisión narrativa]]></article-title>
<article-title xml:lang="en"><![CDATA[Pathophysiology of digital vasculopathy in patients with systemic sclerosis. Narrative review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garcés-Alanis]]></surname>
<given-names><![CDATA[Marco A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Orozco]]></surname>
<given-names><![CDATA[Alain R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Michoacana de San Nicolás de Hidalgo Facultad de Ciencias Médicas y Biológicas Dr. Ignacio Chávez ]]></institution>
<addr-line><![CDATA[Morelia Mich]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2024</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>65</fpage>
<lpage>72</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2696-130X2024000200065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2696-130X2024000200065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2696-130X2024000200065&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Esta revisión se enfoca en la fisiopatología de la vasculopatía digital en pacientes con esclerosis sistémica y en ella se analizan estudios publicados entre los años 2017 y 2023. Se comentan varios mecanismos de daño vascular que explican la fisiopatología de la vasculopatía digital en pacientes con esclerosis sistémica, como la activación no controlada del sistema inmunitario que no permite controlar los cambios profibróticos, predominio de fenómenos de vasoconstricción sobre los de vasodilatación, modificación de la citoarquitectura vascular, angiogénesis ineficaz, disminución de la cantidad de progenitores de células endoteliales, liberación de moléculas inhibitorias de la relación neurovascular, aumento de moléculas de adhesión que promueven la fibrosis y la aparición de úlceras digitales y estimulación de un proceso complejo de transición endotelio-mesénquima. Estos mecanismos pueden amplificar el daño establecido por el creciente estrés oxidativo y los autoanticuerpos, y apuntan a la complejidad de la vasculopatía digital en la esclerosis sistémica; y también permiten abrir nuevas posibilidades para mejorar el diagnóstico y tratamiento de estos pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This review focuses on the pathophysiology of digital vasculopathy in patients with systemic sclerosis and discusses studies published between 2017 and 2023. Several mechanisms of vascular damage that explain the pathophysiology of digital vasculopathy in patients with systemic sclerosis are discussed, such as uncontrolled activation of the immune system that does not allow control of profibrotic changes, predominance of vasoconstriction phenomena over vasodilatation phenomena, modification of vascular cytoarchitecture, ineffective angiogenesis, decrease in the number of endothelial cell progenitors, release of inhibitory molecules of the neurovascular relationship, increase of adhesion molecules that promote fibrosis and the appearance of digital ulcers, and stimulation of a complex process of mesenchymal endothelial transition. These mechanisms could amplify the damage established by increased oxidative stress and autoantibodies. They also point to the complexity of digital vasculopathy in systemic sclerosis and open new possibilities to improve the diagnosis and treatment of these patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Vasculopatía digital]]></kwd>
<kwd lng="es"><![CDATA[Fenómeno de Raynaud]]></kwd>
<kwd lng="es"><![CDATA[Fisiopatología]]></kwd>
<kwd lng="es"><![CDATA[Esclerosis sistémica]]></kwd>
<kwd lng="en"><![CDATA[Digital vasculopathy]]></kwd>
<kwd lng="en"><![CDATA[Raynaud’s phenomenon]]></kwd>
<kwd lng="en"><![CDATA[Pathophysiology]]></kwd>
<kwd lng="en"><![CDATA[Systemic sclerosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkmann]]></surname>
<given-names><![CDATA[ER]]></given-names>
</name>
<name>
<surname><![CDATA[Andréasson]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systemic sclerosis]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2023</year>
<volume>401</volume>
<numero>10373</numero>
<issue>10373</issue>
<page-range>304-18</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Allanore]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Simms]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Distler]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Trojanowska]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pope]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Denton]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systemic sclerosis]]></article-title>
<source><![CDATA[Nat Rev Dis Primers]]></source>
<year>2015</year>
<volume>1</volume>
<page-range>15002</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergamasco]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Wallace]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Verpillat]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease]]></article-title>
<source><![CDATA[Clin Epidemiol]]></source>
<year>2019</year>
<volume>11</volume>
<page-range>257-73</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Carrasco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza-Pinto]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Etchegaray-Morales]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Munguía-Realpozo]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Osorio- Peña]]></surname>
<given-names><![CDATA[ÁD]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro-Milán]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Temporal Trends in mortality in patients with systemic sclerosis in public hospitals across Mexico from 1998-2017]]></article-title>
<source><![CDATA[Arch Med Res]]></source>
<year>2022</year>
<volume>53</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>610-6</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katsumoto]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
<name>
<surname><![CDATA[Whitfield]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Connolly]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The pathogenesis of systemic sclerosis]]></article-title>
<source><![CDATA[Annu Rev Pathol]]></source>
<year>2011</year>
<volume>6</volume>
<page-range>509-37</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cutolo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Soldano]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathophysiology of systemic sclerosis:current understanding and new insights]]></article-title>
<source><![CDATA[Expert Rev Clin Immunol]]></source>
<year>2019</year>
<volume>15</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>753-64</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pauling]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pope]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Raynaud's phenomenon-an update on diagnosis, classification and management]]></article-title>
<source><![CDATA[Clin Rheumatol]]></source>
<year>2019</year>
<volume>38</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>3317-30</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Allanore]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Pauling]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Denton]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
<name>
<surname><![CDATA[Matucci-Cerinic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Raynaud phenomenon and digital ulcers in systemic sclerosis]]></article-title>
<source><![CDATA[Nat Rev Rheumatol]]></source>
<year>2020</year>
<volume>16</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>208-21</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tingey]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Shu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Smuczek]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Pope]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Meta-analysis of healing and prevention of digital ulcers in systemic sclerosis]]></article-title>
<source><![CDATA[Arthritis Care Res (Hoboken)]]></source>
<year>2013</year>
<volume>65</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1460-71</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wirz]]></surname>
<given-names><![CDATA[EG]]></given-names>
</name>
<name>
<surname><![CDATA[Jaeger]]></surname>
<given-names><![CDATA[VK]]></given-names>
</name>
<name>
<surname><![CDATA[Allanore]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Riemekasten]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Hachulla]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Distler]]></surname>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence and predictors of cutaneous manifestations during the early course of systemic sclerosis:a 10-year longitudinal study from the EUSTAR database]]></article-title>
<source><![CDATA[Ann Rheum Dis]]></source>
<year>2016</year>
<volume>75</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>1285-92</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mihai]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Distler]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Gheorghiu]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Constantin]]></surname>
<given-names><![CDATA[PI]]></given-names>
</name>
<name>
<surname><![CDATA[Dobrota]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Jordan]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidence and risk factors for gangrene in patients with systemic sclerosis from the EUSTAR cohort]]></article-title>
<source><![CDATA[Rheumatology (Oxford)]]></source>
<year>2020</year>
<volume>59</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2016-23</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cantatore]]></surname>
<given-names><![CDATA[FP]]></given-names>
</name>
<name>
<surname><![CDATA[Maruotti]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Corrado]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ribatti]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Angiogenesis dysregulation in the pathogenesis of systemic sclerosis]]></article-title>
<source><![CDATA[Biomed Res Int]]></source>
<year>2017</year>
<volume>2017</volume>
<page-range>5345673</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shen]]></surname>
<given-names><![CDATA[CY]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lai]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Hsieh]]></surname>
<given-names><![CDATA[SC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-CENP-B and anti-TOPO-1-containing sera from systemic sclerosis-related diseases with Raynaud's phenomenon induce vascular endothelial cell senescence not via classical p53-p21 pathway]]></article-title>
<source><![CDATA[Clin Rheumatol]]></source>
<year>2018</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>749-56</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gualtierotti]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Ingegnoli]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Griffini]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Grovetti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Borghi]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
<name>
<surname><![CDATA[Bucciarelli]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detection of early endothelial damage in patients with Raynaud's phenomenon]]></article-title>
<source><![CDATA[Microvasc Res]]></source>
<year>2017</year>
<volume>113</volume>
<page-range>22-8</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ross]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Mavria]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Del Galdo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Elies]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Downregulation of vascular hemeoxygenase-1 Leads to vasculopathy in systemic sclerosis]]></article-title>
<source><![CDATA[Front Physiol]]></source>
<year>2022</year>
<volume>13</volume>
<page-range>900631</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Patnaik]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Lyons]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Tran]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Pattanaik]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endothelial dysfunction in systemic sclerosis]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2023</year>
<volume>24</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>14385</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Niazy]]></surname>
<given-names><![CDATA[MH]]></given-names>
</name>
<name>
<surname><![CDATA[Gaber]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Sayed]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Shaker]]></surname>
<given-names><![CDATA[OG]]></given-names>
</name>
<name>
<surname><![CDATA[Gheita]]></surname>
<given-names><![CDATA[TA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The anti-aging protein alpha- Klotho in systemic sclerosis patients:does a relationship to telangiectasia exist?]]></article-title>
<source><![CDATA[Z Rheumatol]]></source>
<year>2020</year>
<volume>79</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>404-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Varga]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Trojanowska]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kuwana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pathogenesis of systemic sclerosis:Recent insights of molecular and cellular mechanisms and therapeutic opportunities]]></article-title>
<source><![CDATA[J Scleroderma Relat Disord]]></source>
<year>2017</year>
<volume>2</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>137-52</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wajda]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Walczyk]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Dudek]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Stypi&#324;ska]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Lewandowska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Romanowska-Próchnicka]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum microRNAs in systemic sclerosis, associations with digital vasculopathy and lung involvement]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2022</year>
<volume>23</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>10731</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jud]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Meinitzer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Strohmaier]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Arefnia]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Wimmer]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Obermayer-Pietsch]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis]]></article-title>
<source><![CDATA[Front Med (Lausanne)]]></source>
<year>2023</year>
<volume>10</volume>
<page-range>1193121</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Utsunomiya]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Oyama]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Hasegawa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Potential biomarkers in systemic sclerosis:a literature review and update]]></article-title>
<source><![CDATA[J Clin Med]]></source>
<year>2020</year>
<volume>9</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>3388</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Matucci-Cerinic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Romano]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Manetti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Current trends in vascular biomarkers for systemic sclerosis:a narrative review]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2023</year>
<volume>24</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>4097</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Michalska-Jakubus]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cutolo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Smith]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Krasowska]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Imbalanced serum levels of Ang1, Ang2 and VEGF in systemic sclerosis:Integrated effects on microvascular reactivity]]></article-title>
<source><![CDATA[Microvasc Res]]></source>
<year>2019</year>
<volume>125</volume>
<page-range>103881</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wermuth]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[Carney]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
<name>
<surname><![CDATA[Mendoza]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<name>
<surname><![CDATA[Piera-Velazquez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Jimenez]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Endothelial cell- specific activation of transforming growth factor-b signaling in mice induces cutaneous, visceral, and microvascular fibrosis]]></article-title>
<source><![CDATA[Lab Invest]]></source>
<year>2017</year>
<volume>97</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>806-18</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romano]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Rosa]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Fioretto]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Matucci-Cerinic]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Manetti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New insights into profibrotic myofibroblast formation in systemic sclerosis:when the vascular wall becomes the enemy]]></article-title>
<source><![CDATA[Life (Basel)]]></source>
<year>2021</year>
<volume>11</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>610</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nicolosi]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Tombetti]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Giovenzana]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Donè]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Pulcinelli]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Meneveri]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Macrophages guard endothelial lineage by hindering endothelial-to-mesenchymal transition:implications for the pathogenesis of systemic sclerosis]]></article-title>
<source><![CDATA[J Immunol]]></source>
<year>2019</year>
<volume>203</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>247-58</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[He]]></surname>
<given-names><![CDATA[YS]]></given-names>
</name>
<name>
<surname><![CDATA[Hu]]></surname>
<given-names><![CDATA[YQ]]></given-names>
</name>
<name>
<surname><![CDATA[Xiang]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Feng]]></surname>
<given-names><![CDATA[YT]]></given-names>
</name>
<name>
<surname><![CDATA[Yin]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Therapeutic potential of galectin-1 and galectin-3 in autoimmune diseases]]></article-title>
<source><![CDATA[Curr Pharm Des]]></source>
<year>2022</year>
<volume>28</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>36-45</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
