<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902025000200099</article-id>
<article-id pub-id-type="doi">10.29262/ram.v72i2.1460</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mimetismo molecular entre el principal alérgeno del ciempiés (Scolopendra subspinipes) Sco M 5 y proteínas de fuentes alergénicas. Análisis in silico]]></article-title>
<article-title xml:lang="en"><![CDATA[Molecular mimicry between the major allergen of the centipede (Scolopendra subspinipes) Sco M 5 and proteins from allergenic sources. In silico analysis.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A4"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[Giovanny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dussan]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Múnera]]></surname>
<given-names><![CDATA[Marlon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Caraballo]]></surname>
<given-names><![CDATA[Jorge Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Corporación Universitaria Rafael Núñez  ]]></institution>
<addr-line><![CDATA[Cartagena ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Corporación Universitaria Rafael Núñez  ]]></institution>
<addr-line><![CDATA[Cartagena ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Cartagena  ]]></institution>
<addr-line><![CDATA[Cartagena ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>72</volume>
<numero>2</numero>
<fpage>99</fpage>
<lpage>106</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902025000200099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902025000200099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902025000200099&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: Evaluar la reactividad cruzada entre Sco m 5 y proteínas de artrópodos mediante análisis in silico e identificar posibles epítopes de unión a IgE.  Métodos: La homología de Sco m 5 y 15 alérgenos de artrópodos (Vespula, Polistes, Polybia, Solenopsis, Brachyponera, Phoneutria y Dermatophagoides) se evaluó con el servidor ALLERMATCH y PRALINE para alineamientos pareados y múltiples, respectivamente. Los árboles filogenéticos se realizaron a través del programa Molecular Evolutionary Genetics Analysis (MEGA). La predicción de epítopes se efectuó con el servidor Ellipro. La visualización de las proteínas se llevó a cabo con Pymol.  Resultados: El alineamiento múltiple arrojó una identidad del 50% y los alineamientos pareados entre Sco m 5 y las proteínas de artrópodos mostraron homología diversa. Dos epítopes lineales y uno conformacional se identificaron en Sco m 5, muy conservados en las proteínas de artrópodos estudiadas, como las abejas, avispas y hormigas.  Conclusión: La alta homología entre Sco m 5 y los alérgenos de otros artrópodos facilita la posible reactividad cruzada. La identificación de potenciales epítopes en regiones conservadas sustenta esta idea y sugieren puntos importantes para blancos terapéuticos en las alergias desencadenadas por venenos de artrópodos, especialmente Scolopendra spp. Es necesario emprender estudios in vitro e in vivo para demostrar estos hallazgos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: To evaluate, through in silico analysis, the cross-reactivity between Sco m 5 and arthropod proteins and to identify potential IgE-binding epitopes.  Methods: The homology between Sco m 5 and 15 arthropod allergens (Vespula, Polistes, Polybia, Solenopsis, Brachyponera, Phoneutria, and Dermatophagoides) was assessed using the ALLERMATCH server for pairwise alignments and PRALINE for multiple alignments. Phylogenetic trees were constructed using Molecular Evolutionary Genetics Analysis (MEGA). Epitope prediction was performed with the Ellipro server. Protein visualization was carried out through PyMOL.  Results: The multiple alignment showed 50% identity, and the pairwise alignments between Sco m 5 and arthropod proteins revealed diverse homology. Two linear epitopes and one conformational epitope were identified in Sco m 5, which were highly conserved in the studied arthropod proteins, such as bees, wasps, and ants.  Conclusion: The high homology between Sco m 5 and allergens from other arthropods supports the potential for cross-reactivity. The identification of potential epitopes in conserved regions reinforces this idea and could serve as important targets for therapeutic interventions in allergies triggered by arthropod venoms, especially Scolopendra spp. Further in vitro and in vivo studies are needed to confirm these findings.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Proteínas de artópodos]]></kwd>
<kwd lng="es"><![CDATA[IgE]]></kwd>
<kwd lng="es"><![CDATA[Epítopes]]></kwd>
<kwd lng="es"><![CDATA[Alérgenos de artrópodos]]></kwd>
<kwd lng="es"><![CDATA[Vespula]]></kwd>
<kwd lng="es"><![CDATA[Polistes]]></kwd>
<kwd lng="es"><![CDATA[Polybia]]></kwd>
<kwd lng="es"><![CDATA[Solenopsis]]></kwd>
<kwd lng="es"><![CDATA[Brachyponera]]></kwd>
<kwd lng="es"><![CDATA[Phoneutria]]></kwd>
<kwd lng="es"><![CDATA[Dermatophagoides]]></kwd>
<kwd lng="es"><![CDATA[Proteína de veneno con alta concentración de cisteína]]></kwd>
<kwd lng="es"><![CDATA[alergia]]></kwd>
<kwd lng="es"><![CDATA[Análisis in silico]]></kwd>
<kwd lng="en"><![CDATA[Arthropod proteins]]></kwd>
<kwd lng="en"><![CDATA[IgE]]></kwd>
<kwd lng="en"><![CDATA[Epitopes]]></kwd>
<kwd lng="en"><![CDATA[Arthropod allergens]]></kwd>
<kwd lng="en"><![CDATA[Vespula]]></kwd>
<kwd lng="en"><![CDATA[Polistes]]></kwd>
<kwd lng="en"><![CDATA[Polybia]]></kwd>
<kwd lng="en"><![CDATA[Solenopsis]]></kwd>
<kwd lng="en"><![CDATA[Brachyponera]]></kwd>
<kwd lng="en"><![CDATA[Phoneutria]]></kwd>
<kwd lng="en"><![CDATA[Dermatophagoides]]></kwd>
<kwd lng="en"><![CDATA[High-cysteine venom protein]]></kwd>
<kwd lng="en"><![CDATA[Allergy]]></kwd>
<kwd lng="en"><![CDATA[In silico analysis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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