<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902023000400284</article-id>
<article-id pub-id-type="doi">10.29262/ram.v70i4.1339</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desensibilización con alimentos]]></article-title>
<article-title xml:lang="en"><![CDATA[Food desensitization]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piraino Sosa]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ojeda Soley]]></surname>
<given-names><![CDATA[Giovanni]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central de la Policía Nacional Rigoberto Caballero Servicio de Alergología ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de previsión Social  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>70</volume>
<numero>4</numero>
<fpage>284</fpage>
<lpage>292</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902023000400284&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902023000400284&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902023000400284&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Hasta hace poco, el enfoque principal para tratar las alergias alimentarias implicaba evitar estrictamente el alérgeno desencadenante. Este método a menudo se consideraba insuficiente, lo que dejaba a los pacientes vulnerables a pequeñas cantidades o fuentes ocultas del alérgeno. La desensibilización, o inducción de tolerancia oral, es un método emergente que se está investigando para el tratamiento de las alergias alimentarias. El objetivo final es conseguir una tolerancia permanente, previniendo reacciones alérgicas tras una nueva exposición al alérgeno tras un periodo de abstinencia. La investigación se ha centrado en la inmunoterapia con alérgenos específicos a través de tres vías: oral, sublingual y epicutánea. La leche, el huevo y el maní son los principales alimentos estudiados debido a su prevalencia en las alergias. Se prefiere la inducción oral porque la ingestión de una persona no alérgica induce una respuesta inmune sin desencadenar una reacción alérgica. La atención de pacientes se ha desplazado de evitar el alergeno a ofrecer estrategias de consumo temprano para prevenir las alergias. En este enfoque se considera crucial el rango de edad de 4 a 6 meses. Se necesita investigación continua para evaluar los detalles de la población, los efectos a largo plazo, la viabilidad y la seguridad de estas estrategias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  In recent times, the primary approach to treating food allergies involved strict avoidance of the triggering allergen. Many considered this approach as lacking true treatment, leaving patients vulnerable to even small amounts or hidden sources of the allergenic food. Desensitization or Oral Tolerance Induction (OTI) is a studied method aiming for a lasting tolerance to the allergen. The ultimate goal is permanent tolerance, where allergic reactions won't reoccur after new exposure to the triggering allergen, following a period of abstinence. The research mainly focuses on allergen-specific immunotherapy, covering three routes: oral, sublingual, and epicutaneous immunotherapy. Milk, egg, and peanuts are the extensively studied foods due to their prevalence in allergies. The oral route is favored for inducing tolerance because ingestion of a food antigen by a non-allergic individual triggers an active immune response without causing an allergic reaction. The paradigm has shifted from recommending avoidance to early consumption strategies to prevent allergies. The period from 4 to 6 months of age is considered immunologically sensitive, where children with risk factors show increased allergic sensitization risk. Implementing these recommendations, considering family and community preferences, may reduce the burden of food allergies and healthcare costs.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Alergia alimentaria]]></kwd>
<kwd lng="es"><![CDATA[Inducción de tolerancia oral]]></kwd>
<kwd lng="es"><![CDATA[Desensibilización]]></kwd>
<kwd lng="es"><![CDATA[Inmunoterapia]]></kwd>
<kwd lng="es"><![CDATA[Anticuerpos monoclonales]]></kwd>
<kwd lng="es"><![CDATA[Aprobación de la FDA]]></kwd>
<kwd lng="es"><![CDATA[Anafilaxia]]></kwd>
<kwd lng="es"><![CDATA[Inmunoterapia con alérgenos]]></kwd>
<kwd lng="es"><![CDATA[Alergia pediátrica]]></kwd>
<kwd lng="en"><![CDATA[Food allergy]]></kwd>
<kwd lng="en"><![CDATA[Oral tolerance induction]]></kwd>
<kwd lng="en"><![CDATA[Desensitization]]></kwd>
<kwd lng="en"><![CDATA[Immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[Monoclonal antibodies]]></kwd>
<kwd lng="en"><![CDATA[FDA Approval]]></kwd>
<kwd lng="en"><![CDATA[Anaphylaxis]]></kwd>
<kwd lng="en"><![CDATA[Allergen immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[Pediatric allergy]]></kwd>
</kwd-group>
</article-meta>
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