<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092024000400284</article-id>
<article-id pub-id-type="doi">10.35366/118219</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Mortalidad con uso de plasmaféresis de alto volumen versus manejo convencional en pacientes con insuficiencia hepática aguda en la Unidad de Cuidados Intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Mortality with use of high-volume plasmapheresis versus conventional management in patients with acute liver failure in the Intensive Care Unit]]></article-title>
<article-title xml:lang="pt"><![CDATA[Mortalidade com o uso de plasmaférese de alto volume vs tratamento convencional em pacientes com insuficiência hepática aguda na Unidade de Terapia Intensiva]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castrejón-Sánchez]]></surname>
<given-names><![CDATA[Jesús Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gasca-Aldama]]></surname>
<given-names><![CDATA[José Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alva-Arroyo]]></surname>
<given-names><![CDATA[Nancy Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amezcua-Gutiérrez]]></surname>
<given-names><![CDATA[Marcos Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Rodríguez]]></surname>
<given-names><![CDATA[Karen Harumi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vidals-Sánchez]]></surname>
<given-names><![CDATA[Marcos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Juárez de México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Ángeles Mocel  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>38</volume>
<numero>4</numero>
<fpage>284</fpage>
<lpage>288</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092024000400284&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092024000400284&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092024000400284&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La insuficiencia hepática aguda es una patología poco común; sin embargo, cuando se presenta requiere de un manejo multidisciplinario y de ingreso a unidad de cuidados intensivos. La incidencia reportada llega a ser de no más de 2,000 casos por año en los Estados Unidos, en México se desconoce la cifra exacta. Las causas más comunes son sobredosis de paracetamol e infección por virus hepatotropos. En los últimos años, con el advenimiento de nuevas tecnologías y nueva evidencia, se han implementado estrategias de tratamiento de soporte hepático extracorpóreo para estos pacientes, como es la plasmaféresis de alto volumen, la cual se ha comparado contra la terapia convencional, reportando resultados con reducción de la mortalidad, menos días de estancia en la unidad de cuidados intensivos y mejores resultados en pacientes trasplantados. En nuestra cohorte, el grupo sobrevivientes utilizó en mayor porcentaje el soporte extracorpóreo con 38.4%, en contraste con el grupo con mayor mortalidad en quienes sólo se usó en 14.3% (p = 0.018), deduciendo que los pacientes con mayor mortalidad no recibieron plasmaféresis y además la muerte ocurrió de manera temprana entre los días uno a tres (p = 0.006). Dicha diferencia presentó significancia estadística en el análisis bivariado. Hasta el momento es el único estudio en unidad de cuidados intensivos en México que evalué la mortalidad en este grupo de pacientes, utilizando el recambio plasmático de alto volumen como terapia extracorpórea versus tratamiento estándar.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Acute liver failure is a rare pathology, however, when it occurs requires multidisciplinary management and admission to the intensive care unit. The reported incidence reaches no more than 2,000 cases per year in the United States, in Mexico the exact Figure is unknown. The most common causes are paracetamol overdose and hepatotropic virus infection. In recent years, with the advent of new technologies and new evidence, extracorporeal support treatment strategies have been implemented for these patients, such as high-volume plasmapheresis, which has been compared against conventional therapy, reporting results with reduced in mortality, less day in the intensive care unit and better results in transplant patients. In our cohort, the survivor group used extracorporeal support in a higher percentage with 38.4%, in contrast to the group with higher mortality in whom it was only used in 14.3% (p = 0.018). Deducing that patients with higher mortality did not receive plasmapheresis and also death occurred early between days 1 to 3 (p = 0.006). This difference presented statistical significance in the bivariate analysis. To date, it is the only study in an intensive care unit in Mexico that evaluated mortality in this group of patients using high volume plasma exchange as a extracorporeal therapy versus standard treatment.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo: A insuficiência hepática aguda é uma patologia incomum; no entanto, quando ocorre, requer tratamento multidisciplinar e internação na unidade de terapia intensiva. A incidência relatada não passa de 2,000 casos por ano nos Estados Unidos; no México, o número exato é desconhecido. As causas mais comuns são overdose de paracetamol e infecção por vírus hepatotropos. Nos últimos anos, com o advento de novas tecnologias e novas evidências, estratégias de tratamento de suporte hepático extracorpóreo foram implementadas para esses pacientes, como a plasmaférese de alto volume, que foi comparada à terapia convencional, relatando redução da mortalidade, menos dias na unidade de terapia intensiva e melhores resultados em receptores de transplante. Em nossa coorte, o grupo sobrevivente usou suporte extracorpóreo em uma porcentagem maior (38.4%), em contraste com o grupo com a maior mortalidade, no qual foi usado em apenas 14.3% (p = 0.018). Conclui-se que os pacientes com maior mortalidade não receberam plasmaférese e que a morte ocorreu precocemente, entre os dias 1 e 3 (p = 0.006). Essa diferença foi estatisticamente significativa na análise bivariada. Até o momento, este é o único estudo realizado em uma unidade de terapia intensiva no México que avalia a mortalidade nesse grupo de pacientes usando a troca de plasma de alto volume como terapia extracorpórea em comparação com o tratamento padrão.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[insuficiencia hepática aguda]]></kwd>
<kwd lng="es"><![CDATA[plasmaféresis]]></kwd>
<kwd lng="es"><![CDATA[soporte extracorpóreo]]></kwd>
<kwd lng="en"><![CDATA[Acute liver failure]]></kwd>
<kwd lng="en"><![CDATA[plasmapheresis]]></kwd>
<kwd lng="en"><![CDATA[extracorporeal support]]></kwd>
<kwd lng="pt"><![CDATA[insuficiência hepática aguda]]></kwd>
<kwd lng="pt"><![CDATA[plasmaférese]]></kwd>
<kwd lng="pt"><![CDATA[suporte extracorpóreo]]></kwd>
</kwd-group>
</article-meta>
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