<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092024000300189</article-id>
<article-id pub-id-type="doi">10.35366/117782</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aclimatización a la hipoxia hipobárica en pacientes con síndrome de distrés respiratorio agudo severo por SARS-CoV-2]]></article-title>
<article-title xml:lang="en"><![CDATA[Acclimatization to hypobaric hypoxia in patients with severe acute respiratory distress syndrome due to SARS-CoV-2]]></article-title>
<article-title xml:lang="pt"><![CDATA[Aclimatação à hipóxia hipobárica em pacientes com síndrome do desconforto respiratório agudo grave por SARS-CoV-2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Pérez]]></surname>
<given-names><![CDATA[Netzahualcóyotl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villafuerte Toral]]></surname>
<given-names><![CDATA[Griselda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López Carrillo]]></surname>
<given-names><![CDATA[Lilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Seguridad Social del Estado de México y Municipios  ]]></institution>
<addr-line><![CDATA[Toluca de Lerdo ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<fpage>189</fpage>
<lpage>192</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092024000300189&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092024000300189&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092024000300189&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  el nativo de la altitud se encuentra en un ambiente de hipoxia permanente, lo que favorece el desarrollo de una protección fisiológica ante el síndrome de distrés respiratorio agudo (SDRA).  Material y métodos:  estudio observacional, retrospectivo, longitudinal, comparativo, en pacientes con SDRA severo por SARS-CoV-2 en grupos categorizados con base en la altitud geográfica del lugar de origen.  Resultados:  se reclutaron 45 pacientes. En el grupo de residentes de baja, media y elevada altitud la supervivencia a 90 días fue de 50, 62.5 y 77.1%, p = 0.546, respectivamente. Los pacientes de baja y media altitud requirieron más días de estancia en terapia intensiva, días de hospitalización y días de ventilación mecánica, cuando se compararon con nativos de elevada altitud (20.6 vs 16.49, p = 0.295; 27.3 vs 24.71, p = 0.595; 20 vs 15.47, p = 0.305, respectivamente).  Conclusión:  la supervivencia en pacientes nativos de elevada altitud tiende a ser mayor con respecto a aquella de pacientes no aclimatados que residen en altitudes medias y bajas, y no ser nativo de elevada altitud se asocia con una tendencia a requerir más días de ventilación mecánica, mayor estancia en terapia intensiva y más días de hospitalización.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  the native of altitude is in an environment of permanent hypoxia, which favors the development of physiological protection against acute respiratory distress syndrome (ARDS).  Material and methods:  observational, retrospective, longitudinal, comparative study in patients with severe ARDS due to SARS-CoV-2 in groups categorized based on the geographical altitude of the place of origin.  Results:  45 patients were recruited. In the group of residents of low, medium and high altitude, the 90-day survival was 50, 62.5 and 77.1%, p = 0.546, respectively. Patients from low and medium altitude required more days of intensive care stay, days of hospitalization and days of mechanical ventilation, when compared to natives from high altitude (20.6 vs 16.49, p = 0.295; 27.3 vs 24.71, p = 0.595; 20 vs 15.47, p = 0.305, respectively).  Conclusion:  survival in patients native to high altitude tends to be greater compared to that of non-acclimatized patients who reside at medium and low altitudes, and not being native to high altitude is associated with a tendency to require more days of mechanical ventilation, longer stay in intensive care and more days of hospitalization.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  o nativo de altitude está em um ambiente de hipóxia permanente, o que favorece o desenvolvimento de proteção fisiológica contra a síndrome do desconforto respiratório agudo (SDRA).  Material e métodos:  estudo observacional, retrospectivo, longitudinal, comparativo em pacientes com SDRA grave devido à SARS-CoV-2 em grupos categorizados de acordo com a altitude geográfica do local de origem.  Resultados:  45 pacientes foram registrados. No grupo de residentes de baixa, média e alta altitude, a sobrevida em 90 dias foi de 50, 62.5 e 77.1%, p = 0.546, respectivamente. Os pacientes de baixa e média altitude precisaram de mais dias de tratamento na Unidade de Terapia Intensiva, dias de hospitalização e dias de ventilação mecânica em comparação com os nativos de alta altitude (20.6 vs 16.49, p = 0.295; 27.3 vs 24.71, p = 0.595; 20 vs 15.47, p = 0.305, respectivamente).  Conclusões:  a sobrevida de pacientes nativos de altitude elevada tende a ser maior do que a de pacientes não aclimatados que residem em altitudes médias e baixas, e o fato de não ser nativo de altitude elevada está associado a uma tendência a exigir mais dias de ventilação mecânica, maior tempo de internação na Unidade de Terapia Intensiva e mais dias de hospitalização.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[SDRA severo]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="es"><![CDATA[hipoxia hipobárica]]></kwd>
<kwd lng="es"><![CDATA[supervivencia]]></kwd>
<kwd lng="en"><![CDATA[severe ARDS]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[hypobaric hypoxia]]></kwd>
<kwd lng="en"><![CDATA[survival]]></kwd>
<kwd lng="pt"><![CDATA[SDRA grave]]></kwd>
<kwd lng="pt"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="pt"><![CDATA[hipóxia hipobárica]]></kwd>
<kwd lng="pt"><![CDATA[sobrevivência]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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