<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-6483</journal-id>
<journal-title><![CDATA[Endoscopia]]></journal-title>
<abbrev-journal-title><![CDATA[Endoscopia]]></abbrev-journal-title>
<issn>2444-6483</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Endoscopia Gastrointestinal A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-64832025000100002</article-id>
<article-id pub-id-type="doi">10.24875/end.24000003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Impacto del uso de inhibidores de bomba de protones en el fenotipo endoscópico de pacientes pediátricos con enfermedad por reflujo gastroesofágico]]></article-title>
<article-title xml:lang="en"><![CDATA[Impact of the use of proton pump inhibitors on the endoscopic phenotype of pediatric patients with gastroesophageal reflux disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Piñón]]></surname>
<given-names><![CDATA[Sergio I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fonseca-Nájera]]></surname>
<given-names><![CDATA[Jorge A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monroy-Ubaldo]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,, Instituto Mexicano del Seguro Social Centro Médico Nacional La Raza Hospital General Dr. Gaudencio González Garza]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2025</year>
</pub-date>
<volume>37</volume>
<numero>1</numero>
<fpage>2</fpage>
<lpage>6</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-64832025000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-64832025000100002&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-64832025000100002&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: El uso de inhibidor de la bomba de protones (IBP) en la enfermedad por reflujo gastroesofágico (ERGE) ha demostrado modificar el fenotipo de presentación erosiva en el estudio endoscópico, sin embargo no se cuenta con estudios en la población pediátrica.  Objetivo: Determinar el impacto del uso de IBP en el diagnóstico de ERGE fenotipo erosivo en la población pediátrica.  Método: Estudio retrospectivo de cohorte realizado de enero de 2021 a agosto de 2022 en pacientes con diagnóstico de ERGE sometidos a esofagogastroduodenoscopia diagnóstica. Se incluyeron menores de 18 años en los cuales se haya descartado otra patología esofágica con expediente clínico completo.  Resultados: El fenotipo erosivo en la ERGE fue más frecuente en el grupo que no utilizaba IBP, encontrándose en 48 casos contra 23 en los que sí lo utilizaban (34 vs. 16%; p = 0.001). En el análisis en relación con la clasificación esofagitis de Los Ángeles y uso de IBP, se encontró en el grado A sin uso de IBP 37 pacientes (26 vs. 16%; p = 0.011), grado B (3.5 vs. 0%; p = 0.028) y grado C (5 vs. 0%; p = 0.006). Hubo mayor frecuencia de esofagitis erosiva en los pacientes con suspensión de IBP al menos dos semanas previas a su esofagogastroduodenoscopia.  Conclusión: Se encontró diferencia estadísticamente significativa entre pacientes sin uso y con uso de IBP en los diferentes grados de esofagitis según la clasificación de Los Ángeles A, B y C.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: The use of proton pump inhibitors (PPIs) has shown to modify the phenotype of erosive presentation in the endoscopic study, however, there are no studies in the pediatric population.  Objective: To determine the impact of the use of PPIs in the diagnosis of erosive phenotype gastroesophageal reflux disease in the pediatric population.  Method: Retrospective observational cohort study from January 2021 to August 2022 in patients diagnosed with gastroesophageal reflux disease who underwent diagnostic esophagogastroduodenoscopy. Children under 18 years of age in whom another esophageal pathology had been ruled out and who had a complete clinical record were included.  Results: The erosive phenotype in gastroesophageal reflux disease was more frequent in the group that did not use PPIs, being found in 48 cases vs. 23 in those that did use it (34 vs. 16%; p = 0.001). In the analysis in relation to the Los Angeles esophagitis classification and use of PPIs, 37 patients were found in grade A without the use of PPIs (26 vs. 16%; p = 0.011), grade B (3.5 vs. 0%; p = 0.028) and grade C (5 vs. 0%; p = 0.006). There was a higher frequency of erosive esophagitis in patients with PPI suspension for at least two weeks prior to their esophagogastroduodenoscopy.  Conclusion: A statistically significant difference was found between patients with and without PPI use in the different grades of oesophagitis according to the Los Angeles A, B and C classification.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Endoscopia]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad por reflujo gastroesofágico]]></kwd>
<kwd lng="es"><![CDATA[Pediatría]]></kwd>
<kwd lng="es"><![CDATA[Inhibidor de bomba de protones]]></kwd>
<kwd lng="es"><![CDATA[ERGE]]></kwd>
<kwd lng="es"><![CDATA[IBP]]></kwd>
<kwd lng="en"><![CDATA[Endoscopy]]></kwd>
<kwd lng="en"><![CDATA[Gastroesophageal reflux disease]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
<kwd lng="en"><![CDATA[Proton pump inhibitor]]></kwd>
<kwd lng="en"><![CDATA[GERD]]></kwd>
<kwd lng="en"><![CDATA[PPI]]></kwd>
</kwd-group>
</article-meta>
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