<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-0705</journal-id>
<journal-title><![CDATA[Nova scientia]]></journal-title>
<abbrev-journal-title><![CDATA[Nova scientia]]></abbrev-journal-title>
<issn>2007-0705</issn>
<publisher>
<publisher-name><![CDATA[Universidad de La Salle Bajío A. C., Coordinación de Investigación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-07052017000200051</article-id>
<article-id pub-id-type="doi">10.21640/ns.v9i19.911</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteína C reactiva como marcador inflamatorio en la enfermedad periodontal]]></article-title>
<article-title xml:lang="en"><![CDATA[C reactive protein as an inflammatory marker in periodontal disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Aguilar]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo-Ávila]]></surname>
<given-names><![CDATA[Bertha Arelly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Marín]]></surname>
<given-names><![CDATA[Eugenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Puerto Solís]]></surname>
<given-names><![CDATA[Marylín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermeo-Escalona]]></surname>
<given-names><![CDATA[Josué R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pozos-Guillén]]></surname>
<given-names><![CDATA[Amaury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Yucatán Facultad de Odontología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma de Yucatán Centro de Investigaciones Regionales &#8220;Dr. Hideyo Noguchi&#8221; Laboratorio de Biología Celular]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad De La Salle Bajío Facultad de Odontología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de San Luis Potosí Doctorado Institucional en Ingeniería y Ciencia de Materiales ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2017</year>
</pub-date>
<volume>9</volume>
<numero>19</numero>
<fpage>51</fpage>
<lpage>64</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-07052017000200051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-07052017000200051&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-07052017000200051&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La Proteína C Reactiva (PCR) es una de las proteínas plasmáticas que aparecen en la fase aguda de la inflamación. La periodontitis se relaciona con niveles elevados de PCR en adultos y con una reducción de la misma después de su tratamiento. La diabetes, por otro lado, es una enfermedad que compromete la respuesta tanto inflamatoria como reparativa del organismo y los tejidos periodontales son particularmente sensibles a su efecto. La PCR por lo tanto, puede ser útil en el diagnóstico y en la determinación de progresión de la enfermedad periodontal (EP). El objetivo del presente estudio fue evaluar los niveles de PCR en pacientes con EP y pacientes con EP y diabetes mellitus tipo 2 (DM2). Se incluyeron 60 sujetos distribuidos en 3 grupos: 15 pacientes con EP (Grupo 1), 15 pacientes con EP y DM2 (grupo 2) y 30 pacientes sistémicamente sanos (grupo 3). A cada uno de los participantes se les realizaron pruebas bioquímicas: Proteína C Reactiva (NycoCard® PCR), HbA1c (NycoCard®) y glucosa en sangre. Para el diagnóstico de la enfermedad periodontal se siguieron los parámetros del 5° Taller Europeo de Periodontología. Para evaluar las diferencias entre los grupos se usó la prueba de Kruskal Wallis. Se encontraron diferencias estadísticas significativas al comparar la concentración de PCR en los 3 grupos (p&lt;0.01), siendo el grupo de pacientes sanos el que presentaba el menor promedio (4.88±0.08) y los mayores promedios para los grupos de EP (5.95±2.23) y EP/DM2 (5.21±0.20). Además se encontraron diferencias significativas (p&lt;0.01) en los tres grupos con respecto a la concentración hemoglobina, talla, IMC y PI. Los resultados indican que los niveles séricos de PCR se elevan en pacientes con EP y en pacientes con EP y DM2. Aunque se notó esta diferencia, existen diversos factores tanto locales como sistémicos que pueden potencialmente influir en los niveles de PCR y estos representan una limitación y dificultad al momento de interpretar las pruebas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract C-Reactive Protein (CRP) is one of the plasma proteins that appear in the acute phase of inflammation. Periodontitis is associated with elevated levels of CRP in adults and with its decreasing after treatment. On the other hand, diabetes is a disease that compromises both the inflammatory and reparative response of the body and the periodontal tissues are particularly sensitive to its effect. Therefore, CRP can be useful for the diagnosis and determination of progression of periodontal disease (PD). The aim of this study was to assess CRP levels in patients with PD and patients with PD and type 2 diabetes (T2D). 60 subjects were included and divided into 3 groups: 15 patients with PD (Group 1), 15 patients with PD and T2D (group 2) and 30 patients systemically healthy (group 3). Each participant underwent biochemical tests: Protein C Reactive (NycoCard® CPR), HbA1c (NycoCard®) and blood glucose test. Weight, height, body mass index (BMI) and periodontal loss of attachment were registered. For diagnosis of periodontal disease, we followed the parameters of the 5th European Workshop on Periodontology. Kruskal Wallis test was used to evaluate the differences between the groups. Significant statistical differences were found when comparing the CRP concentration in the 3 groups (p&lt;0.01), finding that the healthy group showed the lowest mean (4.88±0.08) and the highest mean values were shown in the PE groups (5.95±2.23) and EP/T2D (5.21±0.20). Also, significant differences (p&lt;0.01) were found in the three groups, in relation to hemoglobin concentration, height, body mass index and periodontal loss of attachment. The results indicate that serum levels of CRP rise in patients with PD and in patients with PE and T2D. Although this difference was noted, there are several local and systemic factors that can potentially influence CRP levels and these represent a limitation and difficulty when interpreting the tests.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[PCR]]></kwd>
<kwd lng="es"><![CDATA[enfermedad periodontal]]></kwd>
<kwd lng="es"><![CDATA[DM2]]></kwd>
<kwd lng="es"><![CDATA[HbA1c]]></kwd>
<kwd lng="en"><![CDATA[CRP]]></kwd>
<kwd lng="en"><![CDATA[Periodontal Disease]]></kwd>
<kwd lng="en"><![CDATA[T2D]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Diagnosis and Classification of Diabetes Mellitus]]></article-title>
<collab>American Diabetes Association</collab>
<source><![CDATA[Diabetes Care]]></source>
<year>2010</year>
<volume>33</volume>
<page-range>S62-9</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Periodontal disease and mortality in type 2 diabetes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aramesh]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Tulloch-Reid]]></surname>
</name>
<name>
<surname><![CDATA[Hanson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Sievers]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes Care]]></source>
<year>2005</year>
<volume>28</volume>
<page-range>27-32</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Proteína C reactiva de alta especificidad como marcador de la enfermedad periodontal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arróniz]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Furuya]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Garzán]]></surname>
<given-names><![CDATA[TJ]]></given-names>
</name>
<name>
<surname><![CDATA[Redondo]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[LJA]]></given-names>
</name>
</person-group>
<source><![CDATA[Oral]]></source>
<year>2013</year>
<volume>14</volume>
<page-range>1026-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Interleukin 1 beta levels in gingival crevicular fluid in type 2 diabetes mellitus and adult periodontitis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bulut]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Develioglu]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Taner]]></surname>
<given-names><![CDATA[IL]]></given-names>
</name>
<name>
<surname><![CDATA[Berker]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Oral Science]]></source>
<year>2001</year>
<volume>43</volume>
<page-range>171-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Inflammatory and immune pathways in the pathogenesis of periodontal disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cekici]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kantarci]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hasturk]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Van Dyke]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Periodontology 2000]]></source>
<year>2014</year>
<volume>64</volume>
<page-range>57-80</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Association of all-cause mortality with overweight and obesity using standard body mass index categories]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Flegal]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kit]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Orpana]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Graubard]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of American Medical Association]]></source>
<year>2013</year>
<volume>309</volume>
<page-range>71-82</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Chronic Periodontitis and C-Reactive Protein Levels]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gomes-Filho]]></surname>
<given-names><![CDATA[IS]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Seixas]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Periodontology]]></source>
<year>2011</year>
<volume>82</volume>
<page-range>969-78</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Comparative evaluation of serum C&#8209;reactive protein levels in chronic and aggressive periodontitis patients and association with periodontal disease severity]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goyal]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bey]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Gupta]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[VK.]]></given-names>
</name>
</person-group>
<source><![CDATA[Contemporary Clinical Dentistry]]></source>
<year>2014</year>
<volume>5</volume>
<page-range>484-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Evaluation of serum C reactive protein levels in subjects with aggressive and chronic periodontitis and comparison with healthy controls]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanaparthy]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Kanaparthy]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Niranjan]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Dental Research Journal]]></source>
<year>2012</year>
<volume>9</volume>
<page-range>261-5</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Katagiri]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Nitta]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Nagasawa]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Uchimura]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Izumiyama]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Inagaki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Kikuchi]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Noguchi]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Kanazawa]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Matsuo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Chiba]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Kanamura]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Inue]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Ishikawa]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Izumi]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes Research and Clinical Practice]]></source>
<year>2009</year>
<volume>83</volume>
<page-range>308-15</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Estimation of levels of salivary mucin, amylase and total protein in gingivitis and chronic periodontitis patients]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kejriwal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Bhandary]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Clinical and Diagnostic Research]]></source>
<year>2014</year>
<volume>8</volume>
<page-range>56-60</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Causas y patogenia de la enfermedad periodontal]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kinane]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<source><![CDATA[Periodontol 2000]]></source>
<year>2009</year>
<volume>25</volume>
<edition>Ed Esp</edition>
<page-range>8-20</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Effect of non-surgical periodontal therapy on C-Reactive Protein, oxidative stress, and matrix metalloproteinase (MMP)-9 and MMP-2 levels in patients whith type 2 diabetes: A randomized control study]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koromantzos]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Makrilakis]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Dereka]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Offenbacher]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Katsilambros]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Vrotsos]]></surname>
<given-names><![CDATA[IA]]></given-names>
</name>
<name>
<surname><![CDATA[Madianos]]></surname>
<given-names><![CDATA[PN]]></given-names>
</name>
</person-group>
<source><![CDATA[Jpurnal of Periodontology]]></source>
<year>2012</year>
<volume>83</volume>
<page-range>3-10</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The sixth complication of diabetes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Loe]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[Diabetes Care]]></source>
<year>1993</year>
<volume>16:</volume>
<page-range>329-34</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Recognition of microorganisms and activatin of the immune response mature]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medzhitov]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nature]]></source>
<year>2007</year>
<volume>449</volume>
<page-range>819-26</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[C-reactive protein as a systemic marker of inflammation in periodontitis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pejcic]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Kesic]]></surname>
<given-names><![CDATA[L.J.]]></given-names>
</name>
<name>
<surname><![CDATA[MIlasin]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[European Journal of Clinical Microbiological &amp; Infection Disease]]></source>
<year>2011</year>
<volume>30</volume>
<page-range>407-14</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[La enfermedad periodontal como riesgo de enfermedades sistémicas]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Peña-Sisto]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Peña-Sisto]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Felizola]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Torres-Keiruz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Lao-Salas]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<source><![CDATA[Revista Cubana de Estomatología]]></source>
<year>2008</year>
<volume>45</volume>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Progressive periodontal disease has a simultaneous incremental elevation of gingival crevicular fluid and serum CRP levels]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pradeep]]></surname>
<given-names><![CDATA[A.R]]></given-names>
</name>
<name>
<surname><![CDATA[Shiva-Manjunath]]></surname>
<given-names><![CDATA[R.G]]></given-names>
</name>
<name>
<surname><![CDATA[Kathariya]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Investigative and Clinical Dentistry]]></source>
<year>2010</year>
<volume>1</volume>
<page-range>133-8</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[How has research into cytokine interactions and they role in driving immune responses impacted our understanding of periodontitis]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Preshaw]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Taylor]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Clinical Periodontolology]]></source>
<year>2011</year>
<volume>38</volume>
<page-range>60-84</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[The effect of exercite training modality of C-reactive protein in type 2 diabetes]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Swift]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Johannsen]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Earnest]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Blair]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Church]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<source><![CDATA[Medicine and Science in Sports Exercise]]></source>
<year>2012</year>
<volume>44</volume>
<page-range>1028-36</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[C-Protein Reactive levels and Body Mas Index: elucidating direction of causation through reciprocal Mendelian randomization]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Timpson]]></surname>
<given-names><![CDATA[NJ]]></given-names>
</name>
<name>
<surname><![CDATA[Nosesgaard]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Harbord]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
<name>
<surname><![CDATA[Zacho]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Frayling]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
<name>
<surname><![CDATA[Tybjaer-Hansen]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Davey-Smith]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
</person-group>
<source><![CDATA[International Journal of Obesity]]></source>
<year>2011</year>
<volume>35</volume>
<page-range>300-8</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Discriminative value of inflammatory biomarkers]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tsalik]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Jaggers]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Glickman]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Langley]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Velkinburgh]]></surname>
<given-names><![CDATA[JC.]]></given-names>
</name>
</person-group>
<source><![CDATA[Journal of Emergency Medicine]]></source>
<year>2012</year>
<volume>43</volume>
<page-range>97-106</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<article-title xml:lang=""><![CDATA[Contemporary concepts in the diagnosis of periodontal disease]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wolf]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Lamster]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<source><![CDATA[Dental Clinics of North America]]></source>
<year>2011</year>
<volume>55</volume>
<page-range>47-61</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
