<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-199X</journal-id>
<journal-title><![CDATA[Revista odontológica mexicana]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Odont. Mex]]></abbrev-journal-title>
<issn>1870-199X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Odontología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-199X2022000100099</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteoma salival: alcances y perspectivas para el diagnóstico y monitoreo de la enfermedad periodontal. Revisión de la literatura]]></article-title>
<article-title xml:lang="en"><![CDATA[Salivary proteome: scopes and perspectives for the diagnosis and monitoring of periodontal disease. Literature review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Reyna]]></surname>
<given-names><![CDATA[Luis Alonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Hernández]]></surname>
<given-names><![CDATA[Miryam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Autónoma de México Facultad de Odontología División de Estudios de Posgrado e Investigación]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>1</numero>
<fpage>99</fpage>
<lpage>112</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-199X2022000100099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-199X2022000100099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-199X2022000100099&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  esta revisión de la literatura examina los cambios en el proteoma salival relacionados con la presencia de periodontitis que pueden ser utilizados para el diagnóstico y seguimiento de la enfermedad, esto es posible debido a que la saliva total contiene una variedad de mediadores locales derivados de las respuestas microbianas y del huésped, así como marcadores sistémicos (plasma) que pueden ser útiles en el diagnóstico periodontal.  Objetivo:  documentar los cambios reportados en el proteoma salival asociados con la presencia de periodontitis con potencial para ser utilizados en el diagnóstico y monitoreo de la enfermedad.  Material y métodos:  las bases de datos PubMed, SpringerLink, Google Académico, WILEY y ScienceDirect fueron consultadas utilizando los términos de búsqueda «salivary proteome AND salivary diagnosis; salivary protein profile AND periodontal disease AND periodontitis» con el fin de identificar publicaciones que reportaran cambios en el perfil proteico salival de sujetos diagnosticados con periodontitis. Se incluyeron artículos de revisión, artículos originales publicados en revistas indexadas y documentos de consenso en los idiomas inglés y español.  Resultados:  proteínas salivales como &#945;-amilasa, cistatina-C y mucina-5B fueron reportadas como aumentadas por algunos autores, mientras que proteínas como cistatina-SN, lactoperoxidasa y mucina-7 fueron reportadas como disminuidas cuando se comparó el proteoma salival de sujetos sistémicamente sanos con periodontitis contra sujetos sin periodontitis. Estos resultados confirman la existencia de cambios en el proteoma salival asociados con la presencia de periodontitis.  Conclusiones:  los cambios en el proteoma salival asociados con la presencia de periodontitis identificados en la presente revisión de la literatura requieren ser investigados a mayor profundidad debido a su potencial para ser utilizados en el diagnóstico y monitoreo de la periodontitis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  this literature review examines changes in the salivary proteome related to the presence of periodontitis that can be used for diagnosis and monitoring of the disease, this is possible because whole saliva contains a variety of local mediators derived from microbial and host responses, as well as systemic (plasma) markers that may be useful in periodontal diagnosis.  Objective:  to document reported changes in the salivary proteome associated with the presence of periodontitis with potential for use in the diagnosis and monitoring of the disease.  Material and methods:  the PubMed, SpringerLink, Google Scholar, WILEY and ScienceDirect databases were queried using the search terms «salivary proteome AND salivary diagnosis; salivary protein profile AND periodontal disease AND periodontitis» to identify publications reporting changes in the salivary protein profile of subjects diagnosed with periodontitis. Review articles, original articles published in indexed journals and consensus documents in English and Spanish were included.  Results:  salivary proteins such as &#945;-amylase, cystatin-C, and mucin-5B were reported as increased by some authors, while proteins like cystatin-SN, lactoperoxidase, and mucin-7 were reported as decreased when comparing the salivary protein proteome of systemically healthy subjects with periodontitis versus subjects without periodontitis. These results confirm the existence of changes in the salivary proteome associated with the presence of periodontitis.  Conclusions:  the changes in the salivary proteome associated with the presence of periodontitis identified in the present literature review require further investigation because of their potential for use in the diagnosis and monitoring of periodontitis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[proteoma salival]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico periodontal]]></kwd>
<kwd lng="es"><![CDATA[monitoreo periodontal]]></kwd>
<kwd lng="es"><![CDATA[biomarcadores salivales]]></kwd>
<kwd lng="es"><![CDATA[enfermedad periodontal]]></kwd>
<kwd lng="en"><![CDATA[salivary proteome]]></kwd>
<kwd lng="en"><![CDATA[periodontal diagnosis]]></kwd>
<kwd lng="en"><![CDATA[periodontal monitoring]]></kwd>
<kwd lng="en"><![CDATA[salivary biomarkers]]></kwd>
<kwd lng="en"><![CDATA[periodontal disease]]></kwd>
</kwd-group>
</article-meta>
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