1405-888X 1405-888X S1405-888X2021000100116 10.22201/fesz.23958723e.2021.369 Mexico Mexico Mexico 00 00 2021 00 00 2021 24

2015 10 2 2 160-72 2018 8-108-118 2003 50 1319-30 2009 29 2 2 70-6 2000 12 246-53 2012 20 2 2 221-32 Food and Drug Administration 2018 FDA 2011 FDA 2014 2014 315-46 2018 1 643 643 994-1004 2002 42 3 3 263-71 2009 75 4 4 462-8 2016 Harmonized Tripartite Guideline 2005 2008 20 7 7 806-20 2012 87 5 5 542-8 2004 38 15 15 4097-105 2009 75 4 4 462-8 2016 213 932-9 2019 372 3 3 218-25 2019 18 9 9 1953-60 2008 274 1 1 80-6 2016 164 156-63 2012 58 7 7 295-301 2020 714 2006 254 1-4 1-4 748-57 1989 37 1 1 226-31 1985 325 1 1 265-74 2007 262 1 1 23-8 1992 89 1 1 93-8 2010 145 3-4 3-4 187-97 2016 95-6 2017 19-24 2010 17-8 1989 83 1-2 1-2 7-16 1994 126 3-4 3-4 283-90 2009 6 1 1 278-309 2013 14 7 7 1-11 2008 14 1 1 52-7 2015 26 2 2 3-10 2018 94 3 3 1-5 2010 80 1 1 1-6 2009 2018 142 105-14