<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-0099</journal-id>
<journal-title><![CDATA[Cirujano general]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. gen]]></abbrev-journal-title>
<issn>1405-0099</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Cirugía General A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-00992014000100003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aplicación de carboximetilcelulosa/ácido hialurónico líquido sobre mallas intraperitoneales para disminuir la formación de adherencias. Estudio experimental]]></article-title>
<article-title xml:lang="en"><![CDATA[Use of liquid carboxymethylcellulose/hyaluronic acid on intraperitoneal mesh to reduce adhesion formation: An experimental study]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Farell Rivas]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Santiago]]></surname>
<given-names><![CDATA[Cesar Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mata Quintero]]></surname>
<given-names><![CDATA[Carlos Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuevas Osorio]]></surname>
<given-names><![CDATA[Víctor José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Luna Martínez]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central Sur de Alta Especialidad PEMEX  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2014</year>
</pub-date>
<volume>36</volume>
<numero>1</numero>
<fpage>3</fpage>
<lpage>8</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-00992014000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-00992014000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-00992014000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes:  Las adherencias intraperitoneales tienen un impacto clínico en el paciente muy importante; por tal motivo, nuestro objetivo es confirmar si la aplicación de carboximetilcelulosa/ácido hialurónico (Guardix®) sobre mallas intraperitoneales puede disminuir o evitar la formación de adherencias.  Material y método:  Veintiséis ratas, dividas en 2 grupos de 13: el grupo control, grupo A, y otro tratamiento (experimental), grupo B. En ambos grupos de colocó malla de polipropileno pesado en posición intraperitoneal; al grupo A se aplicó solución salina a la malla y en cavidad abdominal; al grupo B se aplicó Guardix® (ácido hialurónico y carboximetilcelulosa) en la malla y en la cavidad abdominal. Se reoperaron al día 30, para documentar in situ las características de las adherencias y la presencia o no de neoperitonización de la malla.  Resultados:  El resultado fue p = 0,03. En función de la diferencia de promedios, se utilizó la prueba de Fisher, con un valor de 0,026 a favor del grupo experimental en función a la media de formación de adherencias. Se encontró una disminución importante en el grado y la severidad de adherencias de forma estadísticamente significativa en el grupo al que se aplicó Guardix®.  Conclusión:  Guardix® disminuyó la formación de adherencias, a pesar de la presencia de malla de polipropileno pesado intraperitoneal. Estos hallazgos tienen una aplicación clínica importante; además, surge la pregunte sobre si es suficiente que solo las mallas tengan material antiadherente o si es necesario agregar una capa extra sobre las vísceras intraabdominales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective:  Intraperitoneal adhesions have a clinical impact on patient&#8217;s health. Thus, we aimed to confi rm whether the application of carboxymethylcellulose/hyaluronic acid (GUARDIX) on intraperitoneal meshes can reduce or prevent the formation of adhesions.  Material and methods:  26 male rats, in two groups of 13, were used as control group A and treatment group B. In both groups a heavy-weight polypropylene mesh was placed in an intraperitoneal position. In Group A, saline was applied on the mesh and into the abdominal cavity, in Group B, Guardix (hyaluronic acid and carboxymethylcellulose) was applied on the mesh and into the abdominal cavity. At Day 30 the rats were reoperated on to verify the characteristics of adhesions and mesh status.  Results:  The result was significant at a p-value = 0.03. Based on the mean difference, a Fisher&#8217;s test was used; we found a value of 0.026 for the experimental group for the average of adhesion formation. We found a significant decrease in the extent and severity of adhesions in the Guardix group compared to control rats.  Conclusion:  The application of Guardix effectively decreased adhesion formation despite the presence of a heavy-weight intraperitoneal polypropylene mesh. These findings have an important clinical application. There is still a question to be answered: whether it is enough that only meshes have anti-adherence material, or there is a need to add an extra layer on intraabdominal viscera.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Adherencias intraperitoneales]]></kwd>
<kwd lng="es"><![CDATA[Malla]]></kwd>
<kwd lng="es"><![CDATA[Adherencias posquirúrgicas]]></kwd>
<kwd lng="es"><![CDATA[Obstrucción intestinal]]></kwd>
<kwd lng="es"><![CDATA[Adherencias]]></kwd>
<kwd lng="en"><![CDATA[Intraperitoneal adhesions]]></kwd>
<kwd lng="en"><![CDATA[Mesh]]></kwd>
<kwd lng="en"><![CDATA[Surgically induced tissue adhesion]]></kwd>
<kwd lng="en"><![CDATA[Surgical adhesion]]></kwd>
<kwd lng="en"><![CDATA[Peritoneal adhesions]]></kwd>
<kwd lng="en"><![CDATA[Small bowel obstruction]]></kwd>
</kwd-group>
</article-meta>
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