<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412020000300004</article-id>
<article-id pub-id-type="doi">10.24245/gom.v88i3.3594</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cambios en la glucemia en ayunas durante la transición a la menopausia]]></article-title>
<article-title xml:lang="en"><![CDATA[Fasting plasmatic glucose changes during the menopausal transition]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Inaraja]]></surname>
<given-names><![CDATA[Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Thuissard]]></surname>
<given-names><![CDATA[Israel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Andreu]]></surname>
<given-names><![CDATA[Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jodar]]></surname>
<given-names><![CDATA[Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Europea de Madrid  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Europea de Madrid Escuela de Doctorado e Investigación ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Spain</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Quirón Salud Endocrinología ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>88</volume>
<numero>3</numero>
<fpage>146</fpage>
<lpage>153</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412020000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412020000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412020000300004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO:  Evaluar los cambios en la glucemia en ayunas en mujeres en transición a la menopausia.  MATERIALES Y MÉTODOS:  Estudio observacional, retrospectivo, de una cohorte de mujeres atendidas en el Hospital Quirón Salud de Madrid entre 2007 y 2018. Criterios de inclusión: diagnóstico del ginecólogo y al menos una medición en ayunas de la glucemia y perfil lipídico. Los reportes del laboratorio se clasificaron en perimenopáusicos o posmenopáusicos, según la fecha de la última menstruación. Para el análisis estadístico se utilizaron las siguientes pruebas: &#967;2, t de Student, U-Mann Whitney (dependiendo del comportamiento paramétrico) y ANOVA.  RESULTADOS:  Se incluyeron 1949 reportes de glucemia en ayunas: 459 (23.6%) en pacientes en la perimenopausia y 1490 (76.4%) en la posmenopausia (n = 275). La glucemia en ayunas fue significativamente mayor en las mujeres en la posmenopausia (p &lt; 0.001). En el cambio de la glucemia en ayunas a lo largo del tiempo, según la fecha de la última menstruación, se observó un aumento continuo de la glucemia, sin diferencias significativas entre la peri y posmenopausia. La edad al momento de los estudios, la diabetes gestacional, los antecedentes familiares de diabetes y las concentraciones de triglicéridos se asociaron, de forma independiente, con la glucemia en ayunas (p &lt; 0.001 en todos los casos).  CONCLUSIONES:  Las diferencias en la glucemia en ayunas entre los periodos de perimenopausia y posmenopausia son significativas; sin embargo, los datos del cambio de la glucemia ajustados por edad y tratamiento sugieren que el estado menopáusico no actúa de forma independiente en la glucemia en ayunas. Los que sí influyeron fueron: la edad al momento de las mediciones, la diabetes gestacional, los antecedentes familiares de diabetes y las concentraciones de triglicéridos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE:  To evaluate the fasting plasmatic glucose changes during the menopausal transition.  MATERIALS AND METHODS:  This is a retrospective observational study of laboratory studies from women visited in hospital Quirón Salud de Madrid from 2007-2018 years. The inclusion criteria were one or more laboratory studies of fasting plasmatic glucose and lipid profile from women visited because of irregular menstruation, menopausal symptoms and/or amenorrhea. Laboratory studies values were classified as perimenopausal or posmenopausal based on their date of last menstruation. For quantitative variables, Student&#8217;s T or Mann-Whitney U tests (depending on the normality distribution) were applied to analyze differences between perimenopausal and posmenopausal values. Chi-square or Fisher&#8217;s exact test were used for qualitative variables. ANOVA test was performed to compare the glucose quartiles.  RESULTS:  1949 laboratory reports of fasting glucose were included: 459 (23.6%) were perimenopausal and 1490 (76.4%) were posmenopausal, from 275 women with 7.3 laboratory report-women. Fasting plasmatic glucose was higher at the posmenopausal samples (p &lt; 0.001). The evolution of the fasting plasmatic glucose showed a continuous increase that starts during perimenopause. There were no significant differences in the evolution trend between perimenopause and posmenopause. Age in the moment of the blood sample, gestational diabetes, family history of diabetes and triglycerides levels were independently associated with fasting plasmatic glucose (p &lt; 0.001 in all cases).  CONCLUSION:  The differences in fasting blood glucose between periods of perimenopause and posmenopause are significant; however, data on age-adjusted blood glucose change and treatment suggest that menopausal status does not act independently on fasting blood glucose. Those that did influence were: age at the time of the measurements, gestational diabetes, family history of diabetes and triglyceride concentrations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Perimenopausia]]></kwd>
<kwd lng="es"><![CDATA[posmenopausia]]></kwd>
<kwd lng="es"><![CDATA[glucosa sanguínea]]></kwd>
<kwd lng="es"><![CDATA[diabetes, gestacional]]></kwd>
<kwd lng="en"><![CDATA[Perimenopause]]></kwd>
<kwd lng="en"><![CDATA[Postmenopause]]></kwd>
<kwd lng="en"><![CDATA[Blood Glucose]]></kwd>
<kwd lng="en"><![CDATA[Diabetes, Gestational]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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