<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000200195</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre síndrome metabólico e índice neutrófilo/linfocito]]></article-title>
<article-title xml:lang="en"><![CDATA[Relation between metabolic syndrome and neutrophil to lymphocyte ratio]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Copca-Nieto]]></surname>
<given-names><![CDATA[DV]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez-López]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santillán-Fragoso]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez-del Pilar]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López y López]]></surname>
<given-names><![CDATA[LR]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-González]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lagunas-Alvarado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Alférez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Ramos-Méndez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Jiménez]]></surname>
<given-names><![CDATA[AE]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alba-Rangel]]></surname>
<given-names><![CDATA[DL]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Terán-González]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-D'Franchis]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital CTentral Norte de Petróleos Mexicanos  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital CTentral Norte de Petróleos Mexicanos departamento de Endocrinología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital CTentral Norte de Petróleos Mexicanos departamento de Medicina Interna ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>195</fpage>
<lpage>203</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000200195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000200195&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000200195&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: el síndrome metabòlico agrupa factores de riesgo de diabetes mellitus 2 y enfermedad cardiovascular: obesidad central, hiperglucemia, hipertensión arterial, hipertrigliceridemia y colesterol de alta densidad (C-HDL) reducido. La obesidad y el síndrome metabòlico son afecciones en las que sobreviene inflamación subclínica crónica, factor de riesgo independiente de enfermedad cardiovascular y aterosclerosis. El índice neutrófilo/linfocito (INL) ha surgido como un marcador pronóstico asociado con un estado proinflamatorio que refleja el equilibrio entre la respuesta inmunitaria innata y adaptativa.  OBJETIVO: definir la relación entre el índice neutrófilo/linfocito (INL) elevado y el síndrome metabólico en trabajadores activos adscritos al Hospital Central Norte de PEMEX. Los objetivos secundarios fueron establecer la relación entre el índice neutrófilo/linfocito y los componentes del síndrome metabólico individualmente.  MATERIAL Y MÉTODO: estudio retrospectivo, transversal y observacional en el que se evaluaron trabajadores activos de PEMEX de 18 a 65 años de edad y se clasificaron en dos grupos de acuerdo con la existencia o ausencia de síndrome metabólico y se calculó el índice neutrófilo/linfocito de cada uno.  RESULTADOS: se incluyeron 334 pacientes, 155 (46%) no cumplieron criterios para síndrome metabólico y 179 (54%) sí. De los pacientes en el cuartil más alto de índice neutrófilo/linfocito (&gt;2.12) 57 correspondieron al grupo con síndrome metabólico (p=0.000). El coeficiente de correlación biserial puntual entre índice neutrófilo/ linfocito y síndrome metabólico fue de 0.235 (p=0.000); 69 de los 235 pacientes con obesidad central estaban en el cuartil más alto de índice neutrófilo/linfocito (p=0.001).  CONCLUSIONES: los hallazgos sugieren que existe una relación significativa entre la elevación del índice neutrófilo/linfocito (&gt;2.12) y la existencia de síndrome metabólico y obesidad central.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Metabolic syndrome is a cluster of factors that increases the risk for developing type 2 diabetes mellitus and cardiovascular disease (CVD): central obesity, elevated fasting plasma glucose, arterial hypertension, raised triglycerides and reduced high-density lipoprotein cholesterol (HDL-C). Metabolic syndrome and obesity are entities in which chronic subclinical inflammation develops, an independent risk factor for atherosclerosis and CVD. Neutrophil to lymphocyte ratio (NLR) has emerged as a prognostic marker associated to a proinflammatory state, which reflects the balance between innate and adaptive immune responses.  OBJECTIVE: To define the relation between an elevated NLR and the presence of metabolic syndrome in active employees that attend to PEMEX North Central Hospital. Secondary objectives were to establish the relation between NLR and each component of metabolic syndrome individually.  MATERIAL AND METHOD: A retrospective, cross-sectional and observational stud was done including employees 18-65 years old and classified them into 2 groups according to metabolic syndrome criteria, NLR was calculated for every patient.  RESULTS: Of 334 evaluated patients, 155 (46%) didn't meet the metabolic syndrome criteria, and 179 (54%) did. Fifty-seven patients in the highest quartile of NLR (&gt;2.12) corresponded to the metabolic syndrome group (p=0.000). Point biserial correlation coefficient between NLR and metabolic syndrome was 0.235 (p=0.000). Sixty-nine of the 235 patients with central obesity were at the highest quartile of NLR (p=0.001).  CONCLUSION: These findings suggest that there is a statistically significant relation between elevated NLR (&gt;2.12) and presence of metabolic syndrome and central obesity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome metabólico]]></kwd>
<kwd lng="es"><![CDATA[índicTe neutrófilo/linfocito]]></kwd>
<kwd lng="es"><![CDATA[obesidad central]]></kwd>
<kwd lng="es"><![CDATA[inflamación sistémica]]></kwd>
<kwd lng="en"><![CDATA[metabolic syndrome]]></kwd>
<kwd lng="en"><![CDATA[neutrophil to lymphocyte ratio]]></kwd>
<kwd lng="en"><![CDATA[central obesity]]></kwd>
<kwd lng="en"><![CDATA[systemic inflammation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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