<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0026-1742</journal-id>
<journal-title><![CDATA[Revista de la Facultad de Medicina (México)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Fac. Med. (Méx.)]]></abbrev-journal-title>
<issn>0026-1742</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Medicina]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0026-17422014000300009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Bases moleculares de la sepsis]]></article-title>
<article-title xml:lang="en"><![CDATA[Molecular basis of sepsis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo Esper]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tapia Jurado]]></surname>
<given-names><![CDATA[Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña Pérez]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Kim Koh]]></surname>
<given-names><![CDATA[Min Jeong]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jaime Limón]]></surname>
<given-names><![CDATA[Álvaro Rodrigo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montalvo Javé]]></surname>
<given-names><![CDATA[Eduardo E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Fundación Clínica Médica Sur  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,UNAM Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Fundación Clínica Médica Sur  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,UNAM Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,UNAM Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Grupo Mexicano para el Estudio de la Sepsis  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2014</year>
</pub-date>
<volume>57</volume>
<numero>3</numero>
<fpage>9</fpage>
<lpage>21</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0026-17422014000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0026-17422014000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0026-17422014000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La sepsis es un síndrome que continúa siendo una causa importante de morbilidad y mortalidad entre los pacientes críticamente enfermos. Pese al desarrollo de la investigación básica dedicada al tema y los numerosos ensayos clínicos, no se han logrado avances notables en el desarrollo de terapias vanguardistas y eficaces para su manejo. Los trastornos fisiológicos inducidos por la sepsis son en gran parte debidos a la respuesta del huésped a los microorganismos invasores en contraste con los efectos directos del propio microorganismo. La sepsis, entendida como la respuesta inflamatoria sistémica a la infección, está marcada por la producción desregulada de citocinas proinflamatorias. Estos mediadores conducen de manera colectiva a la insuficiencia orgánica múltiple, y en última instancia, a la muerte. Es en este sentido que el papel de la inflamación en la fisiopatogenia de la sepsis, aunque todavía no entendida completamente, resulta claramente crítico. Esta revisión proporciona una perspectiva de las diversas interacciones moleculares que ocurren durante la sepsis, con el intento de poder comprender la naturaleza de la respuesta desregulada del sistema inmunitario durante ésta.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Sepsis continues to be a primary cause of high mortality and morbidity in critically ill patients. Despite constant growth in dedicated basic investigation and numerous clinical studies, no remarkable developments have been made for effective and innovative therapies. The physiologic disorders induced by sepsis are primarily due to the overwhelming immune response to invading pathogens rather than the direct effects caused by the pathogen. Sepsis, understood as the systemic inflammatory response to infection is characterized by the unregulated production of proinflammatory cytokines. These mediators collectively lead to multiple organ failure and eventually to death. In this context, the role of inflammation in the physiopathology of sepsis, though not fully understood, is of critical importance. This review provides a perspective of the most current understandings of the molecular mechanisms during sepsis, which may provide an attempt to understand the nature of this unregulated response of the immune systems during sepsis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sépsis]]></kwd>
<kwd lng="es"><![CDATA[microorganismos invasores]]></kwd>
<kwd lng="es"><![CDATA[infección]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[invading pathogens]]></kwd>
<kwd lng="en"><![CDATA[infection]]></kwd>
</kwd-group>
</article-meta>
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