<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0016-3813</journal-id>
<journal-title><![CDATA[Gaceta médica de México]]></journal-title>
<abbrev-journal-title><![CDATA[Gac. Méd. Méx]]></abbrev-journal-title>
<issn>0016-3813</issn>
<publisher>
<publisher-name><![CDATA[Academia Nacional de Medicina de México A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0016-38132025000400003</article-id>
<article-id pub-id-type="doi">10.24875/gmm.25000009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Impacto económico y caracterización epidemiológica de la sífilis congénita en un hospital público de tercer nivel en Monterrey: análisis 2017-2024]]></article-title>
<article-title xml:lang="en"><![CDATA[Economic impact and epidemiological characterization of congenital syphilis in a tertiary public hospital in Monterrey: analysis 2017-2024]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo-Bejarano]]></surname>
<given-names><![CDATA[José I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vaquera-Aparicio]]></surname>
<given-names><![CDATA[Denisse N.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-López]]></surname>
<given-names><![CDATA[Marcela L.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hodoyán-Leal]]></surname>
<given-names><![CDATA[Mónica E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rosales-González]]></surname>
<given-names><![CDATA[Sara P.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cid-Ramírez]]></surname>
<given-names><![CDATA[María F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarado-Lara]]></surname>
<given-names><![CDATA[Diego A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Cavazos]]></surname>
<given-names><![CDATA[Samantha]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza-Martínez]]></surname>
<given-names><![CDATA[Keila Y.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mascareñas-de los Santos]]></surname>
<given-names><![CDATA[Abiel H.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Dr. José Eleuterio González Servicio de Infectología Pediátrica ]]></institution>
<addr-line><![CDATA[Monterrey ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Dr. José Eleuterio González Departamento de Infectología ]]></institution>
<addr-line><![CDATA[Monterrey ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario Dr. José Eleuterio González Departamento de Pediatría ]]></institution>
<addr-line><![CDATA[Monterrey ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<volume>161</volume>
<numero>4</numero>
<fpage>382</fpage>
<lpage>388</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0016-38132025000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0016-38132025000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0016-38132025000400003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes: La sífilis congénita ha aumentado en prevalencia desde 2001, especialmente en países de ingresos bajos y medianos, constituyendo un problema de salud pública.  Objetivo: Analizar la carga económica y la caracterización epidemiológica de la sífilis congénita en un hospital público de tercer nivel de Monterrey.  Material y métodos: Se incluyeron menores de 2 años hijos de madres con VDRL (Venereal Disease Research Laboratory) o TP-PA (aglutinación de partículas para Treponema pallidum) positivos, de enero de 2017 a diciembre de 2024, en un hospital público de tercer nivel. Se clasificaron de acuerdo con los escenarios de los Centers for Disease Control and Prevention. Se recolectaron variables clínicas y demográficas maternas e infantiles, desenlaces clínicos, costos de hospitalización y tipo de cobertura de salud federal.  Resultados: Se analizaron 321 pacientes. La mediana de hospitalización fue de 4 días, con una mediana de costos de $1533.15 USD. Se observaron costos superiores en sífilis congénita probada ($4221.58 USD) en comparación con otros escenarios clínicos. Se reportó una diferencia estadística entre los tres periodos de cobertura de salud federal ($370.88 vs. $2801.38 vs. $1,532.82 USD; p &lt; 0.001). El 48% de los casos se diagnosticaron posterior al nacimiento.  Conclusiones: Los resultados reflejan la alta carga económica y las tendencias crecientes de la sífilis congénita, con diagnósticos mayormente tardíos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Congenital syphilis has increased in prevalence since 2001, especially in low- and middle-income countries, constituting a public health problem.  Objective: To analyze the economic burden and epidemiological characterization of congenital syphilis in a tertiary public hospital in Monterrey.  Materials and methods: Children under 2 years of age born to mothers with positive VDRL (Venereal Disease Research Laboratory) or TP-PA (particle agglutination for Treponema pallidum), from January 2017 to December 2024, in a public tertiary hospital were included. They were classified according to Centers for Disease Control and Prevention scenarios. Maternal and infant clinical and demographic variables, clinical outcomes, hospitalization costs and type of federal health coverage were collected.  Results: A total of 321 patients were analyzed, and the median hospital stay was 4 days with median costs of $1533.15 USD. Higher costs were observed in proven congenital syphilis ($4221.58 USD) compared to other clinical scenarios. A statistical difference was reported between the costs of the three periods of federal health coverage ($370.88 vs. $2801.38 vs. $1,532.82 USD; p &lt; 0.001). 48% of the cases were diagnosed after birth.  Conclusions: The results reflect the high economic burden and increasing trends of congenital syphilis, with mostly late diagnosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sífilis congénita]]></kwd>
<kwd lng="es"><![CDATA[Costos]]></kwd>
<kwd lng="es"><![CDATA[Hospitalización]]></kwd>
<kwd lng="es"><![CDATA[Centers for Disease Control and Prevention]]></kwd>
<kwd lng="en"><![CDATA[Congenital syphilis]]></kwd>
<kwd lng="en"><![CDATA[Costs]]></kwd>
<kwd lng="en"><![CDATA[Hospitalization]]></kwd>
<kwd lng="en"><![CDATA[Centers for Disease Control and Prevention]]></kwd>
</kwd-group>
</article-meta>
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