<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902021000300209</article-id>
<article-id pub-id-type="doi">10.29262/ram.v68i3.901</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hematemesis en un neonato con síndrome de Heiner. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Hematemesis in a newborn baby with Heiner syndrome. A case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega-Espinosa]]></surname>
<given-names><![CDATA[Anaí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez-Benaiges]]></surname>
<given-names><![CDATA[Miguel Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Pineda]]></surname>
<given-names><![CDATA[Norma Angélica]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morfín-Maciel]]></surname>
<given-names><![CDATA[Blanca María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Star Médica Infantil Privado  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital San Angel Inn Chapultepec  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>68</volume>
<numero>3</numero>
<fpage>209</fpage>
<lpage>213</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902021000300209&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902021000300209&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902021000300209&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción:  El síndrome de Heiner es una enfermedad pulmonar muy rara, pero reversible, debida a una hipersensibilidad no mediada por IgE a las proteínas de la leche de vaca resultando en una enfermedad pulmonar atípica en bebés y lactantes. Se han reportado muy pocos casos. Debido a sus manifestaciones heterogéneas, el diagnóstico puede retrasarse, ya que puede cursar con infecciones respiratorias crónicas o recurrentes de vía aérea alta o baja, fiebre, falla en el crecimiento o síntomas gastrointestinales. Los infiltrados pulmonares pueden ser confundidos con neumonía, pero el síndrome de Heiner es refractario al tratamiento con antibióticos.  Reporte de caso:  Describimos el caso de un neonato de un mes cuyo síntoma principal fue hematemesis, que es un síntoma muy raro. El diagnóstico se confirmó con la remisión total de los síntomas al suprimir de forma estricta la leche y sus derivados.  Conclusiones:  El pronóstico es favorable si se instaura una dieta libre de lácteos tempranamente. La mayoría de los niños tolerarán la leche en pocos años.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction:  Heiner syndrome is a very rare but reversible lung disease caused by non-IgE-mediated hypersensitivity to cow's milk proteins resulting in an atypical pulmonary disease in babies and infants. Very few cases have been reported. Due to its heterogeneous manifestations, the diagnosis can be delayed since it can occur with chronic or recurrent infections of the upper or lower respiratory tract, fever, growth failure, or gastrointestinal symptoms. Pulmonary infiltrates can be mistaken for pneumonia, but Heiner&#8217;s syndrome is refractory to antibiotic treatment.  Case report:  We describe the case of a 1-month-old newborn baby whose main symptom was hematemesis, which is a rare symptom. The diagnosis was confirmed with the complete disappearance of the symptoms when milk and dairy products were strictly avoided.  Conclusions:  The prognosis is favorable if a milk-free diet is begun early. Most children will tolerate cow´s milk within a few years.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome de Heiner]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad pulmonar]]></kwd>
<kwd lng="es"><![CDATA[Hematemesis]]></kwd>
<kwd lng="en"><![CDATA[Heiner syndrome]]></kwd>
<kwd lng="en"><![CDATA[Lung disease]]></kwd>
<kwd lng="en"><![CDATA[Hematemesis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sicherer]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Sampson]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Food allergy A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management]]></article-title>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>2018</year>
<volume>141</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>41-58</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fiocchi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Brozek]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Schünemann]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Bahna]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
<name>
<surname><![CDATA[von Berg]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Beyer]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[World Allergy Organization (WAO) diagnosis and rationale for action against cow's milk allergy (DRACMA) guidelines]]></article-title>
<source><![CDATA[World Allergy Organ J]]></source>
<year>2010</year>
<volume>3</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>57-161</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Moissidis]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Chaidaroon]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Vichyanond]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Bahna]]></surname>
<given-names><![CDATA[SL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Milk-induced pulmonary disease in infants (Heiner syndrome)]]></article-title>
<source><![CDATA[Pediatr Allergy Immunol]]></source>
<year>2005</year>
<volume>16</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>545-52</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heiner]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Sears]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Kniker]]></surname>
<given-names><![CDATA[WT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multiple precipitins to cow's milk in chronic respiratory disease A syndrome including poor growth, gastrointestinal symptoms, evidence of allergy, iron deficiency anemia, and pulmonary hemosiderosis]]></article-title>
<source><![CDATA[Am J Dis Child]]></source>
<year>1962</year>
<volume>103</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>634-54</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergmann]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Eigenmann]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Food Allergy in childhood (Infancy to school age) En: Ebisawa M, Ballmer-Weber BK, Vieths S, Wood RA, editores. Food allergy: molecular basis and clinical practice]]></article-title>
<source><![CDATA[Chem Immunol Allergy]]></source>
<year>2015</year>
<volume>101</volume>
<page-range>38-50</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
<name>
<surname><![CDATA[Kniker]]></surname>
<given-names><![CDATA[WT]]></given-names>
</name>
<name>
<surname><![CDATA[Cook]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Heiner]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cow's milk-induced pulmonary disease in children]]></article-title>
<source><![CDATA[Adv Pediatr]]></source>
<year>1978</year>
<volume>25</volume>
<page-range>39-57</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stafford]]></surname>
<given-names><![CDATA[HA]]></given-names>
</name>
<name>
<surname><![CDATA[Polmar]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Boat]]></surname>
<given-names><![CDATA[TF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immunologic studies in cow's milk-induced pulmonary hemosiderosis]]></article-title>
<source><![CDATA[Pediatr Res]]></source>
<year>1977</year>
<volume>11</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>898-903</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[XY]]></given-names>
</name>
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[XR]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[YM]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hematochezia in a child with Heiner syndrome]]></article-title>
<source><![CDATA[Front Pediatr]]></source>
<year>2019</year>
<volume>7</volume>
<page-range>551-5</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koc]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Sucu]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Celik]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A different clinical presentation of Heiner syndrome The case of diffuse alveolar hemorrhage causing massive hemoptysis and hematemesis]]></article-title>
<source><![CDATA[Resp Med Case Rep]]></source>
<year>2019</year>
<volume>26</volume>
<page-range>206-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Wittig]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heiner's syndrome]]></article-title>
<source><![CDATA[Radiology]]></source>
<year>1969</year>
<volume>92</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>507-8</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ojuawo]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Ojuawo]]></surname>
<given-names><![CDATA[OB]]></given-names>
</name>
<name>
<surname><![CDATA[Aladesanmi]]></surname>
<given-names><![CDATA[AO]]></given-names>
</name>
<name>
<surname><![CDATA[Adio]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
<name>
<surname><![CDATA[Abdulkadir]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Mokuolu]]></surname>
<given-names><![CDATA[OA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heiner syndrome an uncommon cause of failure to thrive]]></article-title>
<source><![CDATA[Malawi Med J]]></source>
<year>2019</year>
<page-range>31</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sigua]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Zacharisen]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heiner syndrome mimicking an immune deficiency]]></article-title>
<source><![CDATA[WMJ]]></source>
<year>2013</year>
<volume>112</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>215-8</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godfrey]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pulmonary hemorrhage/hemoptysis in children]]></article-title>
<source><![CDATA[Pediatr Pulmonol]]></source>
<year>2004</year>
<volume>37</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>476-84</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cunningham-Rundles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Brandeis]]></surname>
<given-names><![CDATA[WE]]></given-names>
</name>
<name>
<surname><![CDATA[Good]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Day]]></surname>
<given-names><![CDATA[NK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Milk precipitins, circulating immune complexes, and IgA deficiency]]></article-title>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>1978</year>
<volume>75</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>3387-9</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Maggiolo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Farbinger]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rubilar]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hemoptisis/hemorragia pulmonar en pediatría]]></article-title>
<source><![CDATA[Neumol Pediatr]]></source>
<year>2009</year>
<volume>4</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>65-72</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González-Ortiz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sangrado de tubo digestivo]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Flores-Calderón]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[González-Ortiz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<source><![CDATA[Enfermedades hepáticas y gastrointestinales en niños. Diagnóstico y tratamiento]]></source>
<year>2017</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[Corinter]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
