<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-9190</journal-id>
<journal-title><![CDATA[Revista alergia México]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. alerg. Méx.]]></abbrev-journal-title>
<issn>2448-9190</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Inmunología Clínica y Alergia A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-91902019000300361</article-id>
<article-id pub-id-type="doi">10.29262/ram.v66i3.596</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Asma: endotipos y fenotipos en la edad pediátrica]]></article-title>
<article-title xml:lang="en"><![CDATA[Asthma: endotypes and phenotypes at a pediatric age]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz-López]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínic de Barcelona Servicio de Inmunología y Alergia Pediátrica ]]></institution>
<addr-line><![CDATA[ Barcelona]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>66</volume>
<numero>3</numero>
<fpage>361</fpage>
<lpage>365</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-91902019000300361&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-91902019000300361&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-91902019000300361&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los términos endotipo y fenotipo se han introducido en los últimos años con la finalidad de identificar las diferentes variantes del asma, tanto en los niños como en los adultos, por la interacción de los factores epigenéticos, como el genotipo, los factores ambientales y los no heredados. Todos estos factores participan en el inicio y progresión del asma, así como los alérgenos ambientales, causantes del asma en la mayoría de los niños y adolescentes. El inicio más tardío de la enfermedad puede estar inducido por las características del ambiente, como ocurre en la mayoría de los adultos (asma ocupacional). En una revisión de un centenar de historias clínicas de niños, unos con antecedentes familiares, otros sin ellos y un grupo más pequeño de 10 pacientes en el que no se detectaron cifras de IgE elevadas, se observaron diferencias evidentes en cuanto a la edad de inicio y otras características, aunque la sensibilización a alérgenos fue muy similar en los tres grupos (a Dermatophagoides).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The concepts of endotype and phenotype have been introduced in the past few years with the purpose of identifying the different variants of asthma in children and adults by the interaction of epigenetic factors, such as genotype, environmental factors, and not inherited factors. All these factors participate in the onset and progression of asthma, as well as environmental allergens, which are the cause of asthma in most children and teenagers. The latest onset may be induced by the characteristics of the environment, as happens in most adults (occupational asthma). In a review of a hundred medical records of children with and without a family history, and of a group of patients in whom high IgE levels were not detected, clear differences were observed in terms of the age of onset and other characteristics, although the sensitization to allergens was very similar in those three groups (Dermatophagoides mites).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Asma]]></kwd>
<kwd lng="es"><![CDATA[Endotipo]]></kwd>
<kwd lng="es"><![CDATA[Fenotipo]]></kwd>
<kwd lng="es"><![CDATA[Genética]]></kwd>
<kwd lng="en"><![CDATA[Asthma]]></kwd>
<kwd lng="en"><![CDATA[Endotype]]></kwd>
<kwd lng="en"><![CDATA[Phenotype]]></kwd>
<kwd lng="en"><![CDATA[Genetics]]></kwd>
</kwd-group>
</article-meta>
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