<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092024000100020</article-id>
<article-id pub-id-type="doi">10.35366/115677</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto del CO2 sobre la mortalidad en pacientes con SDRA por COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of CO2 on mortality in patients with ARDS in COVID-19]]></article-title>
<article-title xml:lang="pt"><![CDATA[Efeito do CO2 na mortalidade em pacientes com SDRA por COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Arce]]></surname>
<given-names><![CDATA[América Alejandrina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Díaz]]></surname>
<given-names><![CDATA[Jesús Salvador]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peniche Moguel]]></surname>
<given-names><![CDATA[Karla Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suárez Rosas]]></surname>
<given-names><![CDATA[Abraham Argenis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Ruiz]]></surname>
<given-names><![CDATA[José Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calyeca Sánchez]]></surname>
<given-names><![CDATA[María Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional «Adolfo Ruiz Cortines» Hospital de Especialidades No. 14]]></institution>
<addr-line><![CDATA[Veracruz ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>38</volume>
<numero>1</numero>
<fpage>20</fpage>
<lpage>26</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092024000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092024000100020&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092024000100020&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la neumonía grave por SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) incrementó la incidencia de SDRA (síndrome de distrés respiratorio agudo). La ventilación protectora disminuye la mortalidad en pacientes con SDRA, dicha estrategia ventilatoria basada en el uso de volumen corriente bajo podría ocasionar hipercapnia. Las alteraciones del CO2 son tan importantes como las de oxigenación en el SDRA.  Objetivo:  evaluar el efecto del CO2 sobre la mortalidad en pacientes con SDRA por COVID-19 con ventilación mecánica invasiva (VMI).  Material y métodos:  estudio cohorte, retrospectivo, observacional, longitudinal. Se realizó en la unidad de cuidados intensivos (UCI) entre el 1 de junio de 2020 y el 31 de diciembre de 2022. Estudio de no intervención.  Resultados:  se incluyeron 115 pacientes, 61.7% hombres. Se clasificaron en tres grupos de acuerdo al valor de PaCO2 de ingreso a unidad de cuidados intensivos: grupo 1 (hipocapnia): PaCO2 &lt; 35 mmHg, grupo 2 (normocapnia): PaCO2 35-45 mmHg, grupo 3 (hipercapnia): PaCO2 &gt; 45 mmHg. La mortalidad global fue de 53%. El grupo 1 presentó OR 0.640 (IC95% 0.181-2.265) p = 0.488, grupo 2 OR1.66 (IC95% 0.673-4.130) p = 0.270 y grupo 3 OR 0.992 (IC95% 0.396-2.489) p = 0.98; otras variables como eficiencia ventilatoria y frecuencia respiratoria presentaron relación inversa a mortalidad con valor de 1.4 y 24, respectivamente.  Conclusión:  la PaCO2 no es un factor de riesgo para predecir mortalidad en los pacientes con SDRA secundario a COVID-19 con ventilación mecánica invasiva. Otras variables como la eficiencia ventilatoria y la frecuencia respiratoria son mediciones pronósticas en nuestra población.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  severe SARS-CoV-2 pneumonia (severe acute respiratory syndrome coronavirus 2) increased the incidence of ARDS (acute respiratory distress syndrome). Protective ventilation reduces mortality in patients with ARDS; such a ventilatory strategy based on the use of low tidal volume could cause hypercapnia. CO2 (carbon dioxide) alterations are as important as oxygenation alterations in ARDS.  Objective:  to evaluate the effect of CO2 on mortality in patients with ARDS in COVID-19 with invasive mechanical ventilation (IMV).  Material and methods:  cohort, retrospective, observational, longitudinal study. It was carried out in the intensive care unit (ICU) between June 1, 2020 and December 31, 2022. Non-intervention study. RESULTS. 115 patients were included, 61.7% men. They were classified into 3 groups according to the PaCO2 value upon admission to the ICU: group 1 (hypocapnia): PaCO2 &lt; 35 mmHg, group 2 (normocapnia): PaCO2 35-45 mmHg, group 3 (hypercapnia): PaCO2 &gt; 45 mmHg. Overall mortality was 53%. Group 1 presented OR 0.640 (95% CI 0.181-2.265) p = 0.488, group 2 OR1.66 (95% CI 0.673-4.130) p = 0.270 and group 3 OR 0.992 (95% CI 0.396-2.489) p = 0.98, Other variables such as ventilatory efficiency (VE) and respiratory rate (RR) presented an inverse relationship to mortality with a value of 1.4 and 24 respectively.  Conclusion:  PaCO2 is not a risk factor to predict mortality in patients with ARDS secondary to COVID-19 with invasive mechanical ventilation. Other variables such as ventilatory efficiency and respiratory rate are prognostic measurements in our population.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Introdução:  a pneumonia grave por SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) aumentou a incidência de SDRA (síndrome do desconforto respiratório agudo). A ventilação protetora reduz a mortalidade em pacientes com SDRA; tal estratégia ventilatória baseada no uso de baixo volume corrente poderia causar hipercapnia. As alterações de CO2 (dióxido de carbono) são tão importantes quanto as alterações de oxigenação na SDRA.  Objetivo:  avaliar o efeito do CO2 na mortalidade em pacientes com SDRA por COVID-19 em ventilação mecânica invasiva (VMI).  Material e métodos:  estudo de coorte, retrospectivo, observacional, longitudinal. Realizou-se na unidade de terapia intensiva (UTI) entre 1º de junho de 2020 e 31 de dezembro de 2022. Estudo sem intervenção.  Resultados:  incluíram-se 115 pacientes, 61.7% homens. Classificaram-se em 3 grupos de acordo com o valor da PaCO2 na admissão na unidade de terapia intensiva: grupo 1 (hipocapnia): PaCO2 &lt; 35 mmHg, grupo 2 (normocapnia): PaCO2 35-45 mmHg, Grupo 3 (hipercapnia): PaCO2 &gt; 45 mmHg. A mortalidade geral foi de 53%. O Grupo 1 apresentou OR 0.640 (IC95% 0.181-2.265) p = 0.488, o grupo 2 OR 1.66 (IC95% 0.673-4.130) p = 0.270 e o grupo 3 OR 0.992 (IC95% 0.396-2.489) p = 0.98, outras variáveis como eficiência ventilatória (EV) e frequência respiratória (FR) apresentaram relação inversa com a mortalidade com valor de 1.4 e 24 respectivamente.  Conclusão:  a PaCO2 não é fator de risco para prever mortalidade em pacientes com SDRA secundária à COVID-19 com ventilação mecânica invasiva. Outras variáveis como eficiência ventilatória e frequência respiratória são medidas prognósticas em nossa população.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de distrés respiratorio agudo]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[PaCO2]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[acute respiratory distress syndrome]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[PaCO2]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="pt"><![CDATA[síndrome do desconforto respiratório agudo]]></kwd>
<kwd lng="pt"><![CDATA[COVID-19]]></kwd>
<kwd lng="pt"><![CDATA[PaCO2]]></kwd>
<kwd lng="pt"><![CDATA[mortalidade]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China]]></article-title>
<source><![CDATA[JAMA Intern Med]]></source>
<year>2020</year>
<volume>180</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>934-43</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2020</year>
<volume>395</volume>
<numero>10229</numero>
<issue>10229</issue>
<page-range>1054-62</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petrucci]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[De Feo]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lung protective ventilation strategy for the acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Cochrane Database Syst Rev]]></source>
<year>2013</year>
<volume>2013</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>CD003844</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Acute Respiratory Distress Syndrome Network; Brower]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Matthay]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2000</year>
<volume>342</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>1301-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amato]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Meade]]></surname>
<given-names><![CDATA[MO]]></given-names>
</name>
<name>
<surname><![CDATA[Slutsky]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Driving pressure and survival in the acute respiratory distress syndrome]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2015</year>
<volume>372</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>747-55</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sinha]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Calfee]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Beitler]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physiologic analysis and clinical performance of the ventilatory ratio in acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2019</year>
<volume>199</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>333-41</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Repessé]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Vieillard-Baron]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hypercapnia during acute respiratory distress syndrome: the tree that hides the forest!]]></article-title>
<source><![CDATA[J Thorac Dis]]></source>
<year>2017</year>
<volume>9</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1420-5</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nin]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Muriel]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Peñuelas]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Brochard]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2017</year>
<volume>43</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>200-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Cai]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Extracorporeal membrane oxygenation for coronavirus disease 2019-induced acute respiratory distress syndrome: a multicenter descriptive study]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2020</year>
<volume>48</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1289-95</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ospina-Tascón]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Bautista]]></surname>
<given-names><![CDATA[DF]]></given-names>
</name>
<name>
<surname><![CDATA[Madriñán]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microcirculatory dysfunction and dead-space ventilation in early ARDS: a hypothesis-generating observational study]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2020</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>35</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morales Quinteros]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bringué Roque]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Kaufman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Artigas Raventós]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Importance of carbon dioxide in the critical patient: Implications at the cellular and clinical levels]]></article-title>
<source><![CDATA[Med Intensiva (Engl Ed)]]></source>
<year>2019</year>
<volume>43</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>234-42</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Giraud]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Banfi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Assouline]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[De Charrière]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cecconi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Bendjelid]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The use of extracorporeal CO2 removal in acute respiratory failure]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2021</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>43</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gounidis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Evangeliou]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Kloura]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Baseline hypocapnia is associated with intubation in COVID-19 diagnosed patients]]></article-title>
<source><![CDATA[medRxiv]]></source>
<year>2021</year>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Von Elm]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Altman]]></surname>
<given-names><![CDATA[DG]]></given-names>
</name>
<name>
<surname><![CDATA[Egger]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies]]></article-title>
<source><![CDATA[J Clin Epidemiol]]></source>
<year>2008</year>
<volume>61</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>344-9</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<collab>ARDS Definition Task Force</collab>
<article-title xml:lang=""><![CDATA[acute respiratory distress syndrome: the Berlin Definition]]></article-title>
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ranieri]]></surname>
<given-names><![CDATA[VM]]></given-names>
</name>
<name>
<surname><![CDATA[Rubenfeld]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
</person-group>
<source><![CDATA[JAMA]]></source>
<year>2012</year>
<volume>307</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>2526-33</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rubio]]></surname>
<given-names><![CDATA[HMA]]></given-names>
</name>
<name>
<surname><![CDATA[Bretón]]></surname>
<given-names><![CDATA[LI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Obesidad en tiempos de COVID-19. Un desafío de salud global]]></article-title>
<source><![CDATA[Endocrinol Diabetes y Nutr]]></source>
<year>2021</year>
<volume>68</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>123-9</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tiruvoipati]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pilcher]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Buscher]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of hypercapnia and hypercapnic acidosis on hospital mortality in mechanically ventilated patients]]></article-title>
<source><![CDATA[Crit Care Med]]></source>
<year>2017</year>
<volume>45</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>e649-56</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tiruvoipati]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Serpa Neto]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An exploratory analysis of the association between hypercapnia and hospital mortality in critically ill patients with sepsis]]></article-title>
<source><![CDATA[Ann Am Thorac Soc]]></source>
<year>2022</year>
<volume>19</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>245-54</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mochizuki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Fujii]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Paul]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Anstey]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acidemia subtypes in critically ill patients: An international cohort study]]></article-title>
<source><![CDATA[J Crit Care]]></source>
<year>2021</year>
<volume>64</volume>
<page-range>10-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nassar]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Should we be permissive with hypercapnia?]]></article-title>
<source><![CDATA[Ann Am Thorac Soc]]></source>
<year>2022</year>
<volume>19</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>165-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gendreau]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Geri]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Pham]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vieillard-Baron]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mekontso Dessap]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2022</year>
<volume>48</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>517-34</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Motos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Riera]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients]]></article-title>
<source><![CDATA[Crit Care]]></source>
<year>2021</year>
<volume>25</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>331</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cressoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cadringher]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Chiurazzi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lung inhomogeneity in patients with acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2014</year>
<volume>189</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>149-58</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Demiselle]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Calzia]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hartmann]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients]]></article-title>
<source><![CDATA[Ann Intensive Care]]></source>
<year>2021</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>88</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shenoy]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Luchtel]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Gulani]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Considerations for target oxygen saturation in COVID-19 patients: are we under-shooting?]]></article-title>
<source><![CDATA[BMC Med]]></source>
<year>2020</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>260</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barrot]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Asfar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Mauny]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Liberal or conservative oxygen therapy for acute respiratory distress syndrome]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2020</year>
<volume>382</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>999-1008</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chu]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[LH]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Lancet]]></source>
<year>2018</year>
<volume>391</volume>
<numero>10131</numero>
<issue>10131</issue>
<page-range>1693-705</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Silva]]></surname>
<given-names><![CDATA[PL]]></given-names>
</name>
<name>
<surname><![CDATA[Ball]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rocco]]></surname>
<given-names><![CDATA[PRM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Physiological and pathophysiological consequences of mechanical ventilation]]></article-title>
<source><![CDATA[Semin Respir Crit Care Med]]></source>
<year>2022</year>
<volume>43</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>321-34</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gattinoni]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Tonetti]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Cressoni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ventilator-related causes of lung injury: the mechanical power]]></article-title>
<source><![CDATA[Intensive Care Med]]></source>
<year>2016</year>
<volume>42</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1567-75</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Uchida]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Respiratory rate as a factor in lung injury-not just what you set, but how you set]]></article-title>
<source><![CDATA[Anesthesiology]]></source>
<year>2023</year>
<volume>138</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>351-3</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pereira]]></surname>
<given-names><![CDATA[RML]]></given-names>
</name>
<name>
<surname><![CDATA[Maia]]></surname>
<given-names><![CDATA[IS]]></given-names>
</name>
<name>
<surname><![CDATA[Laranjeira]]></surname>
<given-names><![CDATA[LN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Driving pressure-limited strategy for patients with acute respiratory distress syndrome. A pilot randomized clinical trial]]></article-title>
<source><![CDATA[Ann Am Thorac Soc]]></source>
<year>2020</year>
<volume>17</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>596-604</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Terragni]]></surname>
<given-names><![CDATA[PP]]></given-names>
</name>
<name>
<surname><![CDATA[Rosboc]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Tealdi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome]]></article-title>
<source><![CDATA[Am J Respir Crit Care Med]]></source>
<year>2007</year>
<volume>175</volume>
<page-range>160-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
