<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-8909</journal-id>
<journal-title><![CDATA[Medicina crítica (Colegio Mexicano de Medicina Crítica)]]></journal-title>
<abbrev-journal-title><![CDATA[Med. crít. (Col. Mex. Med. Crít.)]]></abbrev-journal-title>
<issn>2448-8909</issn>
<publisher>
<publisher-name><![CDATA[Colegio Mexicano de Medicina Crítica A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-89092018000200003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Biomarcadores de la microcirculación versus escala SOFA como predictores de mortalidad en choque séptico]]></article-title>
<article-title xml:lang="en"><![CDATA[Biomarkers of microcirculation versus SOFA scale as predictors of mortality in septic shock]]></article-title>
<article-title xml:lang="pt"><![CDATA[Biomarcadores de microcirculação vs escala sofa como preditores de mortalidade em choque septico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patiño Rosillo]]></surname>
<given-names><![CDATA[Martín Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza Rodríguez]]></surname>
<given-names><![CDATA[Martín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Huerta Valerio]]></surname>
<given-names><![CDATA[René Martín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López González]]></surname>
<given-names><![CDATA[Alfonso]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Secretaría de Salud Hospital General la Villa ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2018</year>
</pub-date>
<volume>32</volume>
<numero>2</numero>
<fpage>66</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-89092018000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-89092018000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-89092018000200003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Objetivo:  Demostrar que la suma de los biomarcadores de la microcirculación: delta de CO2, déficit de base, lactato y ScVO2 central son mejores predictores de mortalidad que la escala SOFA en el choque séptico.  Método de estudio:  Este estudio se programó para realizarse en la Unidad de Cuidados Intensivos (UCI) de un hospital de la Ciudad de México en un periodo comprendido de 1o marzo de 2014 a 1o julio de 2017. Se trata de un estudio comparativo, ambispectivo, observacional y descriptivo. Una vez que se obtuvieron estos datos, se asignó un puntaje a cada uno de los biomarcadores basándose en estudios realizados anteriormente y se creó una nueva escala de valoración a la que se integraron los biomarcadores, la cual fue llamada «escala de biomarcadores de microcirculación» (EBM). De acuerdo con el puntaje obtenido se le asignó un porcentaje de mortalidad que se comparó con la mortalidad de la escala de SOFA ya predeterminada para pacientes con choque séptico. Los resultados arrojados de estas escalas se agruparon en gráficas de correlación de Pearson como variables cuantitativas, en el eje de las abscisas se colocaron los días de estancia hospitalaria y en el eje de las ordenadas el puntaje obtenido. Posteriormente se realizó una asociación con escalas de Pearson entre el puntaje obtenido en las escalas y el porcentaje de mortalidad de cada una de las escalas, logrando una correlación lineal en las dos escalas; sin embargo, se hicieron tablas de correlación entre la escala de SOFA y EBM con el porcentaje de mortalidad en un periodo de 30 días.  Conclusión:  Se descubrió que aunque la capacidad de pronosticar la muerte es más significativa en la escala de SOFA, es poco sensible y más específica; en tanto que la escala de EBM resultó con una sensibilidad de 100% para pronosticar la muerte con una especificidad de 76%, por lo que se considera una escala válida para determinar la muerte en la UCI; no obstante, se requieren estudios más amplios para cotejar la especificidad de esta escala.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Objective:  To demonstrate that the sum of the biomarkers of the microcirculation: CO2 delta, baseline, lactate and central ScVO2 are better predictors of mortality than the SOFA scale in septic shock. Study  Study method:  This study was scheduled to be performed in the ICU of the Hospital of Mexico City in a period from 1 of March 2014 to 1 of July 2017. This is a comparative, ambispective, observational and descriptive. Once these data were obtained, a score was given for each of the biomarkers based on previous studies and a new titration scale was performed where biomarkers were integrated, which was called «microcirculation biomarkers scale» (EBM) and according to the obtained score was assigned a percentage of mortality which was compared with the mortality of the SOFA scale already predetermined for patients with septic shock. The results obtained from these scales were grouped in Pearson correlation graphs as quantitative variables, in the abscissa axis were placed the days of hospital stay and in the axis of the ordinates the obtained score. Subsequently, an association was made with Pearson scales between the scores obtained in the scales with the percentage of mortality of each of the scales, obtaining a linear correlation in the two scales. However, correlation tables between the SOFA and EBM Scale were made The percentage of mortality in a period of 30 days.  Conclusion:  It was found that the ability to predict death, which is more significant in the SOFA scale is less sensitive and more specific, however, the EMB scale resulted with a sensitivity of 100% to predict death with a specificity of 76%. Therefore, it is considered a valid scale to determine death in the ICU, however, more studies are required to compare the specificity of this scale.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[Resumo:  Objetivo:  Demonstrar que a soma dos biomarcadores da microcirculação: Delta de CO2, déficit de base, lactato e ScVO2 central são melhores preditores de mortalidade do que a escala de SOFA no choque séptico.  Método do estudo:  Este estudo foi programado para ser realizado na UTI de um hospital na Cidade do México em um período de 1 de março de 2014 a 1 de julho de 2017. Se trata de um estudo comparativo, ambispectivo, observacional e descritivo. Uma vez que esses dados foram obtidos, foi atribuída uma pontuação para cada um dos Biomarcadores com base em estudos anteriores e foi feita uma nova escala de avaliação onde os Biomarcadores foram integrados, denominado «escala de biomarcadores de microcirculação» (EBM) e de acordo com o escore obtido, foi atribuída uma percentagem de mortalidade que foi comparada com a mortalidade da escala de SOFA já predeterminada para pacientes com choque séptico. Os resultados obtidos a partir dessas escalas foram agrupados em gráficos de correlação de Pearson como variáveis quantitativas, no eixo das abcissas foram colocados os dias de internação e no eixo das ordenadas o escore obtido. Posteriormente, foi feita uma associação com as escalas de Pearson entre o escore obtido nas escalas com a porcentagem de mortalidade de cada uma das escalas, obtendo uma correlação linear nas duas escalas, no entanto, foram feitas tabelas de correlação entre o SOFA e a escala EBM com a porcentagem de mortalidade em um período de 30 dias.  Conclusão:  Verificou-se que a capacidade de prognosticar a morte, a qual é mais significativa na escala SOFA é pouco sensível e mais específica, porém a escala EMB resultou com uma sensibilidade de 100% e uma especificidade de 76% para prognosticar a morte. O que é considerado uma escala válida para determinar a morte na UTI, no entanto, são necessários mais estudos para verificar a especificidade desta escala.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Biomarcadores de microcirculación]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="en"><![CDATA[Microcirculation biomarkers]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="pt"><![CDATA[Biomarcadores de microcirculação]]></kwd>
<kwd lng="pt"><![CDATA[choque séptico]]></kwd>
</kwd-group>
</article-meta>
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