<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2448-5691</journal-id>
<journal-title><![CDATA[Mundo nano. Revista interdisciplinaria en nanociencias y nanotecnología]]></journal-title>
<abbrev-journal-title><![CDATA[Mundo nano]]></abbrev-journal-title>
<issn>2448-5691</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Instituto de Ciencias Aplicadas y Tecnología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2448-56912025000200101</article-id>
<article-id pub-id-type="doi">10.22201/ceiich.24485691e.2025.35.69819</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto citotóxico de nanopartículas de MgO y ZnO en cultivo con células de cáncer oral: nanoacarreadores para tratamientos quimioterapéuticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Cytotoxic effect of MgO and ZnO nanoparticles on oral cancer cell culture: nanocarriers for chemotherapeutic treatments]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores-Ramírez]]></surname>
<given-names><![CDATA[Valeria Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aranda-Herrera]]></surname>
<given-names><![CDATA[Benjamín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guzmán-Rocha]]></surname>
<given-names><![CDATA[Dulce]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Contreras]]></surname>
<given-names><![CDATA[René]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México Escuela Nacional de Estudios Superiores Laboratorio de Investigación Interdisciplinaria (LII), Área de nanoestructuras y Biomateriales]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>18</volume>
<numero>35</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2448-56912025000200101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2448-56912025000200101&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2448-56912025000200101&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El cáncer oral, una de las principales causas de mortalidad a nivel mundial, se trata comúnmente con quimiorradioterapia. No obstante, estas terapias tienen limitaciones. Investigaciones recientes se enfocan en el uso de nanopartículas (NPs) como MgO y ZnO para mejorar el tratamiento. Y, para evaluar el efecto citotóxico de NPs de MgO y ZnO en células cancerígenas de origen linfoblástico, se utilizaron células cancerígenas de cultivo primario de origen linfoblástico caracterizadas por inmunohistoquímica (HIC) y se realizaron pruebas de citotoxicidad utilizando NPs de MgO y ZnO en concentraciones de 0 a 1.33 mg/mL. La viabilidad celular se midió mediante el ensayo MTT por UV-Vis. El análisis estadístico fue mediante la prueba de t-student y ANOVA (p &#8804; 0.05). Los análisis histopatológicos confirmaron la presencia de lesiones neoplásicas linfoblásticas orales con características específicas, positivo a ciclina D1 y negativo a CD3. Los resultados mostraron ligera toxicidad a la máxima dosis para ambas NPs (80% MgO y 94% ZnO) reducción estadísticamente significativa (p &lt; 0.05) dosis-dependiente. Las NPs de MgO y ZnO tienen un ligero efecto citotóxico en células cancerosas linfoblásticas, por lo cual es necesario desarrollar tratamientos quimioterapéuticos más efectivos basados en nanopartículas en combinación con agentes antitumorales para confirmar esta hipótesis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Oral cancer, one of the main causes of mortality worldwide, is commonly treated with chemoradiotherapy. However, these therapies have limitations. Recent research focuses on the use of nanoparticles like MgO and ZnO to improve treatment and to evaluate the nanocytotoxic effect of MgO and ZnO nanoparticles on lymphoblastic-origin cancer cells. Lymphoblastic-origin primary culture cancer cells characterized by immunohistochemistry (IHC) were used, and nanocytotoxicity tests were performed using MgO and ZnO nanoparticles at concentrations ranging from 0 to 1.33 mg/mL. Cell viability was measured using the MTT assay by UV-Vis. Statistical analysis was carried out using the t-student test and ANOVA (p &#8804; 0.05). Histopathological analyses confirmed the presence of oral lymphoblastic neoplastic lesions with specific characteristics, positive for cyclin D1 and negative for CD3. The results showed slight toxicity at the maximum dose for both nanoparticles (80% for MgO and 94% for ZnO) with statistically significant dose-dependent reduction (p &lt; 0.05). MgO and ZnO nanoparticles have a slight cytotoxic effect on lymphoblastic cancer cells, so it is necessary to develop more effective chemotherapeutic treatments based on nanoparticles in combination with antitumor agents to confirm this hypothesis.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[oral cancer]]></kwd>
<kwd lng="en"><![CDATA[nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[anti-tumor]]></kwd>
<kwd lng="en"><![CDATA[dose-response]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas]]></kwd>
<kwd lng="es"><![CDATA[cáncer oral]]></kwd>
<kwd lng="es"><![CDATA[anti-tumor]]></kwd>
<kwd lng="es"><![CDATA[dosis-respuesta]]></kwd>
</kwd-group>
</article-meta>
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