<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2444-054X</journal-id>
<journal-title><![CDATA[Cirugía y cirujanos]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. cir.]]></abbrev-journal-title>
<issn>2444-054X</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Cirugía A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2444-054X2024000500013</article-id>
<article-id pub-id-type="doi">10.24875/ciru.23000003</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[In total knee arthroplasty surgeries, what is the effective dose of intra-articular tranexamic acid?]]></article-title>
<article-title xml:lang="es"><![CDATA[En cirugías de artroplastia total de rodilla, ¿cuál es la dosis efectiva de ácido tranexámico intraarticular?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[&#350;ahin]]></surname>
<given-names><![CDATA[Ismail G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Özdemir]]></surname>
<given-names><![CDATA[Hüsamettin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Training and Research Hospital of Mu&#287;la S&#305;tk&#305; Koçman University Department of Orthopaedic and Traumatology ]]></institution>
<addr-line><![CDATA[Edirne ]]></addr-line>
<country>Turkey</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Edirne Sultan 1. Murat State Hospital Department of Orthopaedic and Traumatology ]]></institution>
<addr-line><![CDATA[Edirne ]]></addr-line>
<country>Turkey</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2024</year>
</pub-date>
<volume>92</volume>
<numero>5</numero>
<fpage>647</fpage>
<lpage>654</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2444-054X2024000500013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2444-054X2024000500013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2444-054X2024000500013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Objective: The aim of our study was to evaluate the effect of different doses of intra-articular (IA) tranexamic acid (TXA) on blood loss in total knee arthroplasty surgeries and compare it to the control group.  Materials and Methods: A total of 160 patients who underwent unilateral total knee arthroplasty surgery at Edirne State Hospital between 2016 and 2020 were divided into four groups. The estimated blood loss and amount of blood loss from drainage, as well as transfusion rates, were compared between the groups based on surgical pre- and post-operative blood parameters to evaluate the dose effectiveness.  Results: In our study, all TXA groups significantly reduced the estimated blood loss and amount of blood loss from drainage compared to the control group. No statistically significant difference was found between the control group and the group receiving 1 g of TXA in terms of transfusion rates (p = 0.062), and no statistically significant difference was found between the groups receiving 2 g and 3 g of TXA.  Conclusion: The use of 2 g of IA TXA is an effective dose for controlling blood loss in total knee arthroplasty surgeries. Lower doses do not have a significant effect on transfusion rates, whereas higher doses do not significantly increase effectiveness.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Objetivo: El objetivo de nuestro estudio fue evaluar el efecto de diferentes dosis de ácido tranexámico intraarticular en la pérdida de sangre en cirugías de artroplastia total de rodilla y compararlo con el grupo control.  Materiales y métodos: La pérdida de sangre estimada y la cantidad de sangre perdida por drenaje, así como las tasas de transfusión, se compararon entre los grupos en base a los parámetros sanguíneos preoperatorios y postoperatorios quirúrgicos para evaluar la efectividad de la dosis.  Resultados: En nuestro estudio, todos los grupos de ácido tranexámico redujeron significativamente la pérdida de sangre estimada y la cantidad de sangre perdida por drenaje en comparación con el grupo control. No se encontró diferencia estadísticamente significativa entre el grupo control y el grupo que recibió 1 g de TXA en términos de tasas de transfusión (p = 0.062), y no se encontró diferencia estadísticamente significativa entre los grupos que recibieron 2 g y 3 g de TXA.  Conclusión: El uso de 2 g de ácido tranexámico intraarticular es una dosis efectiva para controlar la pérdida de sangre en cirugías de artroplastia total de rodilla. Las dosis más bajas no tienen un efecto significativo en las tasas de transfusión.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Tranexamic acid]]></kwd>
<kwd lng="en"><![CDATA[Total knee arthroplasty]]></kwd>
<kwd lng="en"><![CDATA[Intra-articular]]></kwd>
<kwd lng="en"><![CDATA[Topical]]></kwd>
<kwd lng="en"><![CDATA[Local]]></kwd>
<kwd lng="en"><![CDATA[Blood]]></kwd>
<kwd lng="es"><![CDATA[Ácido tranexámico (TXA)]]></kwd>
<kwd lng="es"><![CDATA[Artroplastia total de rodilla (TKA)]]></kwd>
<kwd lng="es"><![CDATA[Intraarticular]]></kwd>
<kwd lng="es"><![CDATA[Tópico]]></kwd>
<kwd lng="es"><![CDATA[Local]]></kwd>
<kwd lng="es"><![CDATA[Sangre]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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