<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-9028</journal-id>
<journal-title><![CDATA[Ecosistemas y recursos agropecuarios]]></journal-title>
<abbrev-journal-title><![CDATA[Ecosistemas y recur. agropecuarios]]></abbrev-journal-title>
<issn>2007-9028</issn>
<publisher>
<publisher-name><![CDATA[Universidad Juárez Autónoma de Tabasco, Dirección de Investigación y Posgrado]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-90282023000400015</article-id>
<article-id pub-id-type="doi">10.19136/era.a10niii.3730</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Análisis In-silico del perfil farmacocinético y objetivos moleculares de lignanos y terpenos de Bursera microphylla]]></article-title>
<article-title xml:lang="en"><![CDATA[In-silico analysis of pharmacokinetic properties and molecular targets of lignans and terpenes from Bursera microphylla]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres-Moreno]]></surname>
<given-names><![CDATA[Heriberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Romero]]></surname>
<given-names><![CDATA[Julio César]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Martínez]]></surname>
<given-names><![CDATA[Karen Lillian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peraza-Figueroa]]></surname>
<given-names><![CDATA[David Edgardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Salcido-González]]></surname>
<given-names><![CDATA[Beatríz Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oros-Morales]]></surname>
<given-names><![CDATA[Ailyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Robles-Zepeda]]></surname>
<given-names><![CDATA[Ramón Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Sonora Departamento de Ciencias Químico Biológicas y Agropecuarias ]]></institution>
<addr-line><![CDATA[Caborca Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Estatal de Sonora  ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Sonora Departamento de Ciencias Químico Biológicas ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>10</volume>
<numero>spe3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-90282023000400015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-90282023000400015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-90282023000400015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Bursera microphylla A. Gray (Burseraceae) es una planta medicinal mexicana con un destacado potencial antiproliferativo y antiinflamatorio in vitro que ha sido asociado a la presencia de compuestos del tipo lignano y triterpenoide, sin embargo, las propiedades farmacocinéticas (absorción, distribución, metabolismo, y excreción- ADME) y los posibles blancos farmacológicos de estos compuestos son desconocidos. El objetivo del estudio fue establecer in-silico el perfil ADME de los metabolitos bioactivos de B. microphylla y analizar los principales objetivos moleculares que son potencialmente inhibidos por estos compuestos. El análisis ADME de los compuestos de B. microphylla (14 lignanos y 10 terpenos) se realizó utilizando la herramienta SwissADME. La determinación in-silico de los posibles blancos terapéuticos se realizó utilizando el programa SwissTargetPrediction. En general, los lignanos y terpenos de B. microphylla presentaron un perfil ADME favorable. El análisis predictivo arrojó que hinoquinina inhibe a los transportadores de dopamina (DAT) y norepinefrina (NET). Por su parte, &#946;-cariofileno reconoce al receptor cannabinoide tipo 2 (CB2). Compuestos con actividad antiproliferativa como ariensina, burserano, dihidroclusina, picropoligamina y burseranina mostraron alta biodisponibilidad oral. Todos los compuestos analizados mostraron capacidad de inhibir enzimas del metabolismo hepático, como CYP1A2 y CYP2C19. Las propiedades farmacocinéticas y farmacodinámicas aceptables de los lignanos y terpenos de B. microphylla los posicionan como buenos prospectos para ser evaluados en modelos animales de inflamación, analgesia, cáncer y enfermedades psiquiátricas. La potencial inhibición de las CYP&#8217;s es un aspecto que debe ser considerado para evitar reacciones adversas en una terapia combinada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Bursera microphylla A. Gray (Burseraceae) is a Mexican medicinal plant with outstanding antiproliferative and antiinflammatory potential in vitro that has been associated with the presence of lignan and triterpenoid compounds, however, the pharmacokinetic properties (absorption, distribution, metabolism, and excretion- ADME) and the possible pharmacological targets of these compounds are unknown. The objective of this study was to establish in-silico the ADME profile of the bioactive metabolites of B. microphylla and to analyze the main molecular targets that are potentially inhibited by these compounds. ADME analysis of the B. microphylla compounds (14 lignans and 10 terpenes) was performed using the SwissADME tool. The in-silico determination of the potential therapeutic target was performed using the SwissTargetPrediction program. In general, the lignans and terpenes of B. microphylla presented a favorable ADME profile. The predictive analysis showed that hinokinin inhibits the dopamine (DAT) and norepinephrine (NET) transporters. For its part, &#946;-caryophyllene recognizes the cannabinoid receptor type 2 (CB2). Compounds with antiproliferative activity such as ariensin, burseran, dihydroclusin, picropoligamain, and burseranin showed high oral bioavailability. All the compounds analyzed showed the ability to inhibit enzymes of hepatic metabolism, such as CYP1A2 and CYP2C19. The acceptable pharmacokinetic and pharmacodynamic properties of the lignans and terpenes of B. microphylla position them as good prospects to be evaluated in animal models of inflammation, analgesia, cancer, and psychiatric diseases. The potential inhibition of CYPs is an aspect that must be considered to avoid adverse reactions in a combination therapy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Bursera microphylla]]></kwd>
<kwd lng="es"><![CDATA[farmacocinética]]></kwd>
<kwd lng="es"><![CDATA[lignanos]]></kwd>
<kwd lng="es"><![CDATA[terpenos]]></kwd>
<kwd lng="es"><![CDATA[perfil ADME]]></kwd>
<kwd lng="en"><![CDATA[Bursera microphylla]]></kwd>
<kwd lng="en"><![CDATA[pharmacokinetics]]></kwd>
<kwd lng="en"><![CDATA[lignans]]></kwd>
<kwd lng="en"><![CDATA[terpenes]]></kwd>
<kwd lng="en"><![CDATA[ADME profile]]></kwd>
</kwd-group>
</article-meta>
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