<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-1523</journal-id>
<journal-title><![CDATA[Revista mexicana de trastornos alimentarios]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Mex. de trastor. aliment]]></abbrev-journal-title>
<issn>2007-1523</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Iztacala]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-15232020000200406</article-id>
<article-id pub-id-type="doi">10.22201/fesi.20071523e.2020.4.643</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Melanocortinas y su participación en el desarrollo de la obesidad]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Alonso]]></surname>
<given-names><![CDATA[Verónica Elsa]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Urbina]]></surname>
<given-names><![CDATA[Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escartín-Pérez]]></surname>
<given-names><![CDATA[Rodrigo Erick]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mancilla-Díaz]]></surname>
<given-names><![CDATA[Juan Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Autónoma de México FES-Iztacala ]]></institution>
<addr-line><![CDATA[Tlalnepantla ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>10</volume>
<numero>4</numero>
<fpage>406</fpage>
<lpage>420</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-15232020000200406&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-15232020000200406&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-15232020000200406&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La obesidad y el sobrepeso son problemas de origen multifactorial, la interacción de los factores ambientales, genéticos y conductuales parecen ser la clave en el desarrollo de esta patología. Los receptores MC3 (rMC3) y MC4 (rMC4), participan en la regulación del balance energético (consumo de alimento, gasto energético y peso corporal), su mutación genética está asociada con el incremento de la adiposidad y el desarrollo de la obesidad. El conocimiento que se tiene de estos receptores y su función aún es limitado, principalmente con respecto a los rMC3 y, aunque los rMC4 se están posicionando como un blanco terapéutico potencial para el tratamiento de la obesidad, se requiere de mayor investigación clínica. Por lo tanto, el propósito de este documento es presentar evidencia de la participación de los receptores MC3 y MC4 en el desarrollo de la obesidad, a través de los resultados encontrados en algunas investigaciones, tanto en modelos animales como en humanos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Obesity and overweight are problems of multifactorial origin, the interaction of environmental, genetic, and behavioral factors seems to be the key in the development of this pathology. The MC3 (rMC3) and MC4 (rMC4) receptors participate in the regulation of energy balance (food intake, energy expenditure and body weight), their genetic mutation is associated with increased adiposity and the development of obesity. Knowledge of these receptors and their function is still limited, mainly with respect to rMC3 and, although rMC4 are positioning themselves as a potential therapeutic target for the treatment of obesity, further clinical research is required. Therefore, the purpose of this document is to present the participation of MC3 and MC4 receptors in the development of obesity, through the results found in some investigations, both in animal and in human´s models.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[obesidad]]></kwd>
<kwd lng="es"><![CDATA[ingesta de alimento]]></kwd>
<kwd lng="es"><![CDATA[melanocortinas]]></kwd>
<kwd lng="es"><![CDATA[conducta alimentaria]]></kwd>
<kwd lng="es"><![CDATA[peso corporal]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[melanocortins]]></kwd>
<kwd lng="en"><![CDATA[food intake]]></kwd>
<kwd lng="en"><![CDATA[eating behavior]]></kwd>
<kwd lng="en"><![CDATA[body weight]]></kwd>
</kwd-group>
</article-meta>
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