<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2007-1124</journal-id>
<journal-title><![CDATA[Revista mexicana de ciencias pecuarias]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. de cienc. pecuarias]]></abbrev-journal-title>
<issn>2007-1124</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2007-11242016000100127</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Adaptación de Mycobacterium smegmatis ante el agotamiento de nutrientes y su efecto en la expresión de esat-6]]></article-title>
<article-title xml:lang="en"><![CDATA[Adaptation of Mycobacterium smegmatis to nutrient depletion and its effect on esat-6 expression]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Pérez]]></surname>
<given-names><![CDATA[Héctor M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velarde-Félix]]></surname>
<given-names><![CDATA[Sixto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Enriquez-Verdugo]]></surname>
<given-names><![CDATA[Idalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Xicotencatl-Palacios]]></surname>
<given-names><![CDATA[Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaxiola-Camacho]]></surname>
<given-names><![CDATA[Soila M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma de Sinaloa Facultad de Medicina Veterinaria ]]></institution>
<addr-line><![CDATA[Culiacán Sinaloa]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Benemérita Universidad Autónoma de Puebla Facultad de Medicina Veterinaria y Zootecnia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro de Innovación y Desarrollo Educativo  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2016</year>
</pub-date>
<volume>7</volume>
<numero>1</numero>
<fpage>127</fpage>
<lpage>139</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S2007-11242016000100127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S2007-11242016000100127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S2007-11242016000100127&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Cuando los recursos son escasos, las micobacterias detienen su crecimiento para dar paso a los genes de la adaptación. Contrariamente, cuando el crecimiento continúa bajo condiciones de estrés, se activan genes específicos de redes metabólicas para su protección. En este sentido, la proteína codificada por esat-6 (por sus siglas en inglés: early secretory antigenic target, 6 kDa) en Mycobacterium tuberculosis, actúa en la lisis del epitelio alveolar y membranas de los macrófagos para escapar e invadir otras células. Pero puede tener otras funciones, tales como interferir en el contacto célula-célula y transferir su ADN. En M. smegmatis, el sistema ESX-1 (por sus siglas en inglés: Secretion Ejectosoma BOX) facilita la secreción de la proteína ESAT-6, probablemente es sensible a uno o más nutrientes del medio de cultivo. Por lo que en el presente estudio se evalúan las condiciones de cultivo limitantes en nutrientes para el crecimiento de M. smegmatis y su relación con la expresión del gen esat-6. Los medios de cultivos probados fueron Hartmans de Bond medio mínimo (HdB), limitado en carbono (HdB&lt;C), nitrógeno (HdB&lt;N) y fosfato inorgánico (HdB&lt;Pi). M. smegmatis se adapta a HdB medio mínimo, HdB&lt;C y HdB&lt;N y reanuda su actividad metabólica en medio fresco, pero no se expresa esat-6. En HdB&lt;Pi M. smegmatis pierde su capacidad metabólica respecto a la resistencia alcohol-ácido y expresa esat-6. Por lo tanto, se proponen los medios de cultivo probados como modelo para la expresión génica bajo limitación por nutrientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: When resources are scarce, mycobacteria stop growing to make way for genes adaptation allow. Conversely, when growth continues under stress conditions, specific genes metabolic networks for protection are activating. In this sense, the protein encoded by esat-6 (early secretory antigenic target, 6 kDa) gene in Mycobacterium tuberculosis, acting in the lysis of alveolar epithelial and macrophage membranes to escape and invade other cells. But it can have other functions, such as interfering with cell-cell contact and transfer their DNA. In M. smegmatis, the ESX-1 (Secretion Ejectosoma BOX) system that facilitates secretion of ESAT-6 protein, probably it is sensitive to one or more nutrients of the culture medium. So it in the present study culture conditions limiting nutrient for growth of M. smegmatis are evaluated and relate the expression of esat-6. Culture media tested were minimal medium Hartmans Bond (HdB), carbon-limited (HdB&lt;C), nitrogen (HdB&lt;N) and inorganic phosphate (HdB&lt;Pi). M. smegmatis HdB adapted to minimal medium, HdB&lt;C and HdB&lt;N and resume its metabolic activity in fresh medium, but not expressed esat-6. In HdB &lt;Pi M. smegmatis loses its metabolic capacity for resistance acid-alcohol and expressed esat-6. Therefore, the culture media tested as a model for gene expression under nutrient limitation is proposed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Metabolismo]]></kwd>
<kwd lng="es"><![CDATA[Aletargamiento]]></kwd>
<kwd lng="es"><![CDATA[Adaptación]]></kwd>
<kwd lng="es"><![CDATA[Estrés]]></kwd>
<kwd lng="es"><![CDATA[Agotamiento de nutrientes]]></kwd>
<kwd lng="es"><![CDATA[Mycobacterium smegmatis]]></kwd>
<kwd lng="es"><![CDATA[esat-6]]></kwd>
<kwd lng="en"><![CDATA[Metabolism]]></kwd>
<kwd lng="en"><![CDATA[Dormancy]]></kwd>
<kwd lng="en"><![CDATA[Adaptation]]></kwd>
<kwd lng="en"><![CDATA[Stress]]></kwd>
<kwd lng="en"><![CDATA[Nutrient depletion]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium smegmatis]]></kwd>
<kwd lng="en"><![CDATA[esat-6]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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