<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1870-7203</journal-id>
<journal-title><![CDATA[Acta médica Grupo Ángeles]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd. Grupo Ángeles]]></abbrev-journal-title>
<issn>1870-7203</issn>
<publisher>
<publisher-name><![CDATA[Grupo Ángeles, Servicios de Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1870-72032023000100046</article-id>
<article-id pub-id-type="doi">10.35366/109021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Proteína C reactiva ultrasensible como marcador proinflamatorio y su asociación con la obesidad]]></article-title>
<article-title xml:lang="en"><![CDATA[Ultrasensitive C reactive protein as a proinflammatory marker and its association with obesity]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Reyes]]></surname>
<given-names><![CDATA[Pablo Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Seniscal Arredondo]]></surname>
<given-names><![CDATA[Daniel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Taracena Pacheco]]></surname>
<given-names><![CDATA[Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Fuentes]]></surname>
<given-names><![CDATA[Ana Karen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villanueva Jiménez]]></surname>
<given-names><![CDATA[Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benítez Benítez]]></surname>
<given-names><![CDATA[Luis Felipe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias Siu]]></surname>
<given-names><![CDATA[Pavel Yael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Greene]]></surname>
<given-names><![CDATA[Enrique Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Angeles Pedregal Clínica Diagnóstica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad La Salle Hospital Angeles Pedregal Facultad Mexicana de Medicina]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Valle de México Hospital Angeles Pedregal Área de Investigación y Enseñanza]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Angeles Pedregal División de Educación Médica ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2023</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<fpage>46</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1870-72032023000100046&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1870-72032023000100046&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1870-72032023000100046&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  la proteína C ultrasensible (PCRus) es un biomarcador inflamatorio producido principalmente en el hígado. La obesidad ha sido ligada a un proceso inflamatorio crónico y tiene una conexión cercana con dicho biomarcador al sobreexpresar citocinas proinflamatorias derivadas del tejido adiposo.  Objetivo:  estudiar la asociación de la obesidad con la elevación de la PCRus como marcador proinflamatorio en población mexicana.  Material y métodos:  estudio retrospectivo y transversal. Se utilizaron registros de PCRus en pacientes de la clínica de medicina preventiva en un hospital privado de la Ciudad de México, de enero a junio de 2019. Población: 672 pacientes mayores de 20 años; 419 hombres y 253 mujeres, con datos de índice de masa corporal (IMC) y PCRus &lt; 10 mg/L. Se realizó regresión lineal múltiple con transformaciones logarítmicas de PCRus, IMC y sexo.  Resultados:  el coeficiente para el logaritmo natural de IMC resultó positivo y estadísticamente significativo (p &lt; 0.001), el coeficiente para sexo masculino resultó negativo y estadísticamente significativo (p &lt; 0.001), el modelo obtuvo una R(2) = 0.17.  Conclusiones:  la elevación de PCRus se encontró asociada de manera positiva con el IMC y positiva con el sexo femenino; sin embargo, el modelo es poco explicativo, ya que existen elevaciones del PCRus en ambos grupos, aunque fue mayor en pacientes con obesidad, con o sin comorbilidades, esto sugiere que la PCRus es un marcador inflamatorio asociado a obesidad en población mexicana.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  usCRP is an inflammatory biomarker produced in the liver. Obesity has been associated with a chronic inflammatory process and linked with said biomarker by overexpressing pro-inflammatory cytokines produced in adipose tissue.  Objectives:  study the association between elevated usCRP as a pro-inflammatory marker in patients with a diagnosis of obesity in the Mexican population.  Material and methods:  retrospective and cross-sectional study; registries of usCRP in patients of the preventive medicine clinic in a private hospital in Mexico City were reviewed from January to June 2019. The population included 672 patients, of which 419 were male and 253 female at least 20 years of age, in whom usCRP values &lt; 10 mg/L. We performed a multiple linear regression with logarithmic transformations of usCRP, BMI, and sex.  Results:  the coefficient for the natural logarithm for the BMI was positive and statistically significant (p &lt; 0.001), the coefficient for the male sex turned a negative and statistically significant result (p &lt; 0.001), and the model obtained an R(2) = 0.17.  Conclusions:  a positive association between elevated usCRP, female sex, and BMI were found; however, this model does not manage to explain all elevations in usCRP, meaning that we found elevations in both groups. More significant elevations were found in obese patients, with or without comorbidities, thus suggesting that usCRP is an inflammatory marker associated with obesity in Mexican population.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[obesidad]]></kwd>
<kwd lng="es"><![CDATA[proteína C reactiva ultrasensible]]></kwd>
<kwd lng="es"><![CDATA[marcador proinflamatorio]]></kwd>
<kwd lng="es"><![CDATA[inflamación sistémica crónica]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[ultra-sensitive C reactive protein]]></kwd>
<kwd lng="en"><![CDATA[proinflammatory marker]]></kwd>
<kwd lng="en"><![CDATA[chronic systemic inflammation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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