<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442025000400005</article-id>
<article-id pub-id-type="doi">10.24875/rmn.23000058</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The relation between the dopaminergic system, drug addiction, and brain structures related to reward behaviors and decision-making]]></article-title>
<article-title xml:lang="es"><![CDATA[La relación entre el sistema dopaminérgico, la drogadicción y las estructuras cerebrales relacionadas con las conductas de recompensa y la toma de decisiones]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Parra-Abarca]]></surname>
<given-names><![CDATA[Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palacios-Pérez]]></surname>
<given-names><![CDATA[Hugo B.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Baldivia-Noyola]]></surname>
<given-names><![CDATA[Petra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz-Concepción]]></surname>
<given-names><![CDATA[Brenda de la]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zambrano-Dávila]]></surname>
<given-names><![CDATA[Juana I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Autonomous University of Guerrero Department of Behavioral Neuroscience Laboratory Faculty of Information Sciences and Technologies]]></institution>
<addr-line><![CDATA[Acapulco ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Autonomous University of Guerrero Faculty of Information Sciences and Technologies Algorithms Laboratory]]></institution>
<addr-line><![CDATA[Acapulco ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Autonomous University of Guerrero Faculty of Chemical-Biological Sciences Molecular Biology and Genomic Laboratory]]></institution>
<addr-line><![CDATA[Chilpancingo ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2025</year>
</pub-date>
<volume>26</volume>
<numero>4</numero>
<fpage>136</fpage>
<lpage>145</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442025000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442025000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442025000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Drug addiction is a serious global health problem that affects the brain, behavior, and decision-making of people, leading to an inability to control drug use. The pharmacological effects of drugs, experienced as a reward, are driven by a variety of genetic, environmental, developmental, and psychosocial factors and are mainly regulated by the dopaminergic system in the reward circuit, with the ventral tegmental area and nucleus accumbens being the most important. Dopamine, the main neurotransmitter, is responsible for regulating physiological functions, including reward-related behaviors. When substance abuse occurs, dopamine is released in greater quantities, forming a connection between the substance and the feeling of reward, thus creating a desire for more pleasurable effects. Dopamine receptors also play a direct role in generating intracellular signals related to pleasure and rewards. Drugs with addictive potential can downregulate the activity and expression of dopamine receptors in the brain. This review focuses on understanding the role of dopamine, the dopaminergic system, and brain structures related to rewards and associated behaviors in drug addiction.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La drogadicción es un grave problema de salud global que afecta al cerebro, la conducta y la toma de decisiones de las personas, lo que lleva a una incapacidad para controlar el consumo de sustancias. Los efectos farmacológicos de las drogas, experimentados como una recompensa, están impulsados por una variedad de factores genéticos, ambientales, del desarrollo y psicosociales, y están regulados principalmente por el sistema dopaminérgico en el circuito de recompensa, siendo el área tegmental ventral y el núcleo accumbens las regiones más importantes. La dopamina, el principal neurotransmisor, es responsable de regular funciones fisiológicas, incluidas las conductas relacionadas con la recompensa. Cuando se produce el consumo de sustancias, se libera dopamina en mayores cantidades, formando una conexión entre la sustancia y la sensación de recompensa, lo que genera el deseo de experimentar nuevamente esos efectos placenteros. Los receptores de dopamina también desempeñan un papel directo en la generación de señales intracelulares relacionadas con el placer y la recompensa. Las drogas con potencial adictivo pueden disminuir la actividad y la expresión de los receptores de dopamina en el cerebro. Esta revisión se centra en comprender el papel de la dopamina, el sistema dopaminérgico y las estructuras cerebrales relacionadas con la recompensa y las conductas asociadas en la adicción a las drogas.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Addiction]]></kwd>
<kwd lng="en"><![CDATA[Drugs]]></kwd>
<kwd lng="en"><![CDATA[Reward]]></kwd>
<kwd lng="en"><![CDATA[Decision-making]]></kwd>
<kwd lng="en"><![CDATA[Dopamine]]></kwd>
<kwd lng="es"><![CDATA[Adicción]]></kwd>
<kwd lng="es"><![CDATA[Drogas]]></kwd>
<kwd lng="es"><![CDATA[Recompensa]]></kwd>
<kwd lng="es"><![CDATA[Toma de decisiones]]></kwd>
<kwd lng="es"><![CDATA[Dopamina]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Merlin]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Archaeological evidence for the tradition of psychoactive plant use in the old world]]></article-title>
<source><![CDATA[Econ Bot]]></source>
<year>2003</year>
<volume>57</volume>
<page-range>295-323</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Michaelides]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Baler]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The neuroscience of drug reward and addiction]]></article-title>
<source><![CDATA[Physiol Rev]]></source>
<year>2019</year>
<volume>99</volume>
<page-range>2115-40</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldman]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Oroszi]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ducci]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The genetics of addiction:uncovering the genes]]></article-title>
<source><![CDATA[Nat Rev Genet]]></source>
<year>2005</year>
<volume>6</volume>
<page-range>521-32</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koob]]></surname>
<given-names><![CDATA[GF]]></given-names>
</name>
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neurobiology of addiction:a neurocircuitry analysis]]></article-title>
<source><![CDATA[Lancet Psychiatry]]></source>
<year>2016</year>
<volume>3</volume>
<page-range>760-73</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schultz]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuronal reward and decision signals:from theories to data]]></article-title>
<source><![CDATA[Physiol Rev]]></source>
<year>2015</year>
<volume>95</volume>
<page-range>853-951</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ernst]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Luciana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroimaging of the dopamine/reward system in adolescent drug use]]></article-title>
<source><![CDATA[CNS Spectr]]></source>
<year>2015</year>
<volume>20</volume>
<page-range>427-41</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Goldstein]]></surname>
<given-names><![CDATA[RZ]]></given-names>
</name>
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dysfunction of the prefrontal cortex in addiction:neuroimaging findings and clinical implications]]></article-title>
<source><![CDATA[Nat Rev Neurosci]]></source>
<year>2011</year>
<volume>12</volume>
<page-range>652-69</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The brain on drugs:from reward to addiction]]></article-title>
<source><![CDATA[Cell]]></source>
<year>2015</year>
<volume>162</volume>
<page-range>712-25</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Parvaz]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Klein]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Woicik]]></surname>
<given-names><![CDATA[PA]]></given-names>
</name>
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Goldstein]]></surname>
<given-names><![CDATA[RZ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroimaging for drug addiction and related behaviors]]></article-title>
<source><![CDATA[Rev Neurosci]]></source>
<year>2011</year>
<volume>22</volume>
<page-range>609-24</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Fowler]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The addicted human brain:insights from imaging studies]]></article-title>
<source><![CDATA[J Clin Invest]]></source>
<year>2003</year>
<volume>111</volume>
<page-range>1444-551</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di]]></surname>
<given-names><![CDATA[Chiara G]]></given-names>
</name>
<name>
<surname><![CDATA[Bassareo]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reward system and addiction:what dopamine does and doesn't do]]></article-title>
<source><![CDATA[Curr Opin Pharmacol]]></source>
<year>2007</year>
<volume>7</volume>
<page-range>69-76</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alavi]]></surname>
<given-names><![CDATA[SS]]></given-names>
</name>
<name>
<surname><![CDATA[Ferdosi]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jannatifard]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Eslami]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Alaghemandan]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Setare]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Behavioral addiction versus substance addiction:correspondence of psychiatric and psychological views]]></article-title>
<source><![CDATA[Int J Prev Med]]></source>
<year>2011</year>
<volume>3</volume>
<page-range>290-4</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lewis]]></surname>
<given-names><![CDATA[RG]]></given-names>
</name>
<name>
<surname><![CDATA[Florio]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Punzo]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Borrelli]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Brain's reward system in health and disease]]></article-title>
<source><![CDATA[Adv Exp Med Biol]]></source>
<year>2021</year>
<volume>1344</volume>
<page-range>57-69</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[Wise]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Baler]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The dopamine motive system:implications for drug and food addiction]]></article-title>
<source><![CDATA[Nat Rev Neurosci]]></source>
<year>2017</year>
<volume>18</volume>
<page-range>741-52</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nestler]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
<name>
<surname><![CDATA[Carlezon Jr]]></surname>
<given-names><![CDATA[WA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mesolimbic dopamine reward circuit in depression]]></article-title>
<source><![CDATA[Biol Psychiatry]]></source>
<year>2006</year>
<volume>59</volume>
<page-range>1151-9</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Steketee]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Kalivas]]></surname>
<given-names><![CDATA[PW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug wanting:behavioral sensitization and relapse to drug-seeking behavior]]></article-title>
<source><![CDATA[Pharmacol Rev]]></source>
<year>2011</year>
<volume>63</volume>
<page-range>348-65</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bouarab]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Thompson]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Polter]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[VTA GABA neurons at the interface of stress and reward]]></article-title>
<source><![CDATA[Front Neural Circuits]]></source>
<year>2019</year>
<volume>13</volume>
<page-range>78</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lüscher]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Malenka]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug-evoked synaptic plasticity in addiction:from molecular changes to circuit remodeling]]></article-title>
<source><![CDATA[Neuron]]></source>
<year>2011</year>
<volume>69</volume>
<page-range>650-63</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dafny]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Rosenfeld]]></surname>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neurobiology of drugs of abuse]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Conn]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
</person-group>
<source><![CDATA[Conn's Translational Neuroscience]]></source>
<year>2017</year>
<page-range>715-22</page-range><publisher-loc><![CDATA[United States ]]></publisher-loc>
<publisher-name><![CDATA[University of Texas McGovern Medical School Houston, TX, Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polter]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Kauer]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stress and VTA synapses:implications for addiction and depression]]></article-title>
<source><![CDATA[Eur J Neurosci]]></source>
<year>2014</year>
<volume>39</volume>
<page-range>1179-88</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[YS]]></given-names>
</name>
<name>
<surname><![CDATA[Sammartino]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Young]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Corrigan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Krishna]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Rezai]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anatomic review of the ventral capsule/ventral striatum and the nucleus accumbens to guide target selection for deep brain stimulation for deep brain stimulation for obsessive-compulsive disorder]]></article-title>
<source><![CDATA[World Neurosurg]]></source>
<year>2019</year>
<volume>126</volume>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Becker-Krail]]></surname>
<given-names><![CDATA[DD]]></given-names>
</name>
<name>
<surname><![CDATA[Walker 2nd]]></surname>
<given-names><![CDATA[WH]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The ventral tegmental area and nucleus accumbens as circadian oscillators:implications for drug abuse and substance use disorders]]></article-title>
<source><![CDATA[Front Physiol]]></source>
<year>2022</year>
<volume>13</volume>
<page-range>886704</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castro]]></surname>
<given-names><![CDATA[DC]]></given-names>
</name>
<name>
<surname><![CDATA[Bruchas]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A motivational and neuropeptidergic HUB:anatomical and functional diversity within the nucleus accumbens shell]]></article-title>
<source><![CDATA[Neuron]]></source>
<year>2019</year>
<volume>102</volume>
<page-range>529-52</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Klawonn]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Malenka]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nucleus accumbens modulation in reward and aversion]]></article-title>
<source><![CDATA[Cold Spring Harb Symp Quant Biol]]></source>
<year>2018</year>
<volume>83</volume>
<page-range>119-29</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salgado]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Kaplitt]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The nucleus accumbens:a comprehensive review]]></article-title>
<source><![CDATA[Stereotact Funct Neurosurg]]></source>
<year>2015</year>
<volume>93</volume>
<page-range>75-93</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baker]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Jhou]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Matsumoto]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mizumori]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
<name>
<surname><![CDATA[Stephenson-Jones]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Vicentic]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The lateral habenula circuitry:Reward processing and cognitive control]]></article-title>
<source><![CDATA[J Neurosci]]></source>
<year>2016</year>
<volume>36</volume>
<page-range>11482-8</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Burton]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Roesch]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From ventral-medial to dorsal-lateral striatum:neural correlates of reward-guided decision-making]]></article-title>
<source><![CDATA[Neurobiol Learn Mem]]></source>
<year>2015</year>
<volume>117</volume>
<page-range>51-9</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lipton]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzales]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Citri]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dorsal striatal circuits for habits, compulsions, and addictions]]></article-title>
<source><![CDATA[Front Syst Neurosci]]></source>
<year>2019</year>
<volume>13</volume>
<page-range>28</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Volkow]]></surname>
<given-names><![CDATA[ND]]></given-names>
</name>
<name>
<surname><![CDATA[George]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Koob]]></surname>
<given-names><![CDATA[GF]]></given-names>
</name>
<name>
<surname><![CDATA[McLellan]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neurobiologic advances from the brain disease model of addiction]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2016</year>
<volume>374</volume>
<page-range>363-71</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Serafini]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Pryce]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Zachariou]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The mesolimbic dopamine system in chronic pain and associated affective comorbidities]]></article-title>
<source><![CDATA[Biol Psychiatry]]></source>
<year>2020</year>
<volume>87</volume>
<page-range>64-73</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hughes]]></surname>
<given-names><![CDATA[RN]]></given-names>
</name>
<name>
<surname><![CDATA[Bakhurin]]></surname>
<given-names><![CDATA[KI]]></given-names>
</name>
<name>
<surname><![CDATA[Petter]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Watson]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Friedman]]></surname>
<given-names><![CDATA[AD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ventral tegmental dopamine neurons control the impulse vector during motivated behavior]]></article-title>
<source><![CDATA[Curr Biol]]></source>
<year>2020</year>
<volume>30</volume>
<page-range>2681-94.e5</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scaplen]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Kaun]]></surname>
<given-names><![CDATA[KR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reward from bugs to bipeds:a comparative approach to understanding how reward circuits function]]></article-title>
<source><![CDATA[J Neurogenet]]></source>
<year>2016</year>
<volume>30</volume>
<page-range>133-48</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nut]]></surname>
<given-names><![CDATA[DJ]]></given-names>
</name>
<name>
<surname><![CDATA[Lingford-Hughes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Erritzoe]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Stokes]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The dopamine theory of addiction:40 years of highs and lows]]></article-title>
<source><![CDATA[Nat Rev Neurosci]]></source>
<year>2015</year>
<volume>16</volume>
<page-range>305-12</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saal]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dong]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Bonci]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Melenka]]></surname>
<given-names><![CDATA[RC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons]]></article-title>
<source><![CDATA[Neuron]]></source>
<year>2003</year>
<volume>37</volume>
<page-range>577-82</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koob]]></surname>
<given-names><![CDATA[GF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neural mechanisms of drug reinforcement]]></article-title>
<source><![CDATA[Ann N Y Acad Sci]]></source>
<year>1992</year>
<volume>654</volume>
<page-range>171-91</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Gu]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
<name>
<surname><![CDATA[Zhan]]></surname>
<given-names><![CDATA[CG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanism for cocaine blocking the transport of dopamine:insights from molecular modeling and dynamics simulations]]></article-title>
<source><![CDATA[J Phys Chem B]]></source>
<year>2009</year>
<volume>113</volume>
<page-range>15057-66</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koob]]></surname>
<given-names><![CDATA[GF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neurobiology of opioid addiction:opponent process, hyperkatifeia, and negative reinforcement]]></article-title>
<source><![CDATA[Biol Psychiatry]]></source>
<year>2020</year>
<volume>87</volume>
<page-range>44-53</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carlson]]></surname>
<given-names><![CDATA[NR]]></given-names>
</name>
</person-group>
<source><![CDATA[Physiology of Behavior]]></source>
<year>2013</year>
<edition>11th</edition>
<publisher-loc><![CDATA[oston ]]></publisher-loc>
<publisher-name><![CDATA[Pearson]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wise]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dopamine and reward:the anhedonia hypothesis 30 years on]]></article-title>
<source><![CDATA[Neurotox Res]]></source>
<year>2008</year>
<volume>14</volume>
<page-range>169-83</page-range></nlm-citation>
</ref>
<ref id="B40">
<label>40</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brischoux]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Chakraborty]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Brierley]]></surname>
<given-names><![CDATA[DI]]></given-names>
</name>
<name>
<surname><![CDATA[Ungless]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli]]></article-title>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2009</year>
<volume>106</volume>
<page-range>4894-9</page-range></nlm-citation>
</ref>
<ref id="B41">
<label>41</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martel]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[McArthur]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dopamine receptor subtypes, physiology and pharmacology:new ligands and concepts in schizophrenia]]></article-title>
<source><![CDATA[Front Pharmacol]]></source>
<year>2020</year>
<volume>11</volume>
<page-range>1003</page-range></nlm-citation>
</ref>
<ref id="B42">
<label>42</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dreyer]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Herrik]]></surname>
<given-names><![CDATA[KF]]></given-names>
</name>
<name>
<surname><![CDATA[Berg]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
<name>
<surname><![CDATA[Hounsgaard]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of phasic and tonic dopamine release on receptor activation]]></article-title>
<source><![CDATA[J Neurosci]]></source>
<year>2010</year>
<volume>30</volume>
<page-range>14273-83</page-range></nlm-citation>
</ref>
<ref id="B43">
<label>43</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Winters]]></surname>
<given-names><![CDATA[KC]]></given-names>
</name>
<name>
<surname><![CDATA[Arria]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Adolescent brain development and drugs]]></article-title>
<source><![CDATA[Prev Res]]></source>
<year>2011</year>
<volume>18</volume>
<page-range>21-4</page-range></nlm-citation>
</ref>
<ref id="B44">
<label>44</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gogtay]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Giedd]]></surname>
<given-names><![CDATA[JN]]></given-names>
</name>
<name>
<surname><![CDATA[Lusk]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hayashi]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
<name>
<surname><![CDATA[Greenstein]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Vaituzis]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dynamic mapping of human cortical development during childhood through early adulthood]]></article-title>
<source><![CDATA[Proc Natl Acad Sci U S A]]></source>
<year>2004</year>
<volume>101</volume>
<page-range>8174-9</page-range></nlm-citation>
</ref>
<ref id="B45">
<label>45</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Grabenhorst]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Rolls]]></surname>
<given-names><![CDATA[ET]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Value, pleasure and choice in the ventral prefrontal cortex]]></article-title>
<source><![CDATA[Trends Cogn Sci]]></source>
<year>2011</year>
<volume>15</volume>
<page-range>56-67</page-range></nlm-citation>
</ref>
<ref id="B46">
<label>46</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hiser]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Koenigs]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology]]></article-title>
<source><![CDATA[Biol Psychiatry]]></source>
<year>2018</year>
<volume>83</volume>
<page-range>638-47</page-range></nlm-citation>
</ref>
<ref id="B47">
<label>47</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Duvarci]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Pared]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Amygdala microcircuits controlling learned fear]]></article-title>
<source><![CDATA[Neuron]]></source>
<year>2014</year>
<volume>82</volume>
<page-range>966-80</page-range></nlm-citation>
</ref>
<ref id="B48">
<label>48</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Janak]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Tye]]></surname>
<given-names><![CDATA[KM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[From circuits to behavior in the amygdala]]></article-title>
<source><![CDATA[Nature]]></source>
<year>2015</year>
<volume>517</volume>
<page-range>282-92</page-range></nlm-citation>
</ref>
<ref id="B49">
<label>49</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gabriele]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[See]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reversible inactivation of the basolateral amygdala, but not the dorsolateral caudate putamen, attenuates consolidation of cocaine-cue associative learning in a reinstatement model of drug-seeking]]></article-title>
<source><![CDATA[Eur J Neurosci]]></source>
<year>2010</year>
<volume>32</volume>
<page-range>1024-9</page-range></nlm-citation>
</ref>
<ref id="B50">
<label>50</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sciascia]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Reese]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Janak]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Chaudhri]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alcohol-seeking triggered by discrete pavlovian cues is invigorated by alcohol contexts and mediated by glutamate signaling in the basolateral amygdala]]></article-title>
<source><![CDATA[Neuropsychopharmacology]]></source>
<year>2015</year>
<volume>40</volume>
<page-range>2801-12</page-range></nlm-citation>
</ref>
<ref id="B51">
<label>51</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chang]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Peng]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Liao]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zou]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Deep brain stimulation in drug addiction treatment:research progress and perspective]]></article-title>
<source><![CDATA[Front Psychiatry]]></source>
<year>2022</year>
<volume>13</volume>
<page-range>858638</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
