<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-5044</journal-id>
<journal-title><![CDATA[Revista mexicana de neurociencia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. neurocienc.]]></abbrev-journal-title>
<issn>1665-5044</issn>
<publisher>
<publisher-name><![CDATA[Academia Mexicana de Neurología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-50442019000500210</article-id>
<article-id pub-id-type="doi">10.24875/rmn.19000112</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Thrombolytic therapy for acute stroke in Mexico: Experience of four Mexican hospitals]]></article-title>
<article-title xml:lang="es"><![CDATA[Terapia trombolítica para el infarto cerebral agudo en México: experiencia de cuatro hospitales Mexicanos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arauz]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendez]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soriano-Navarro]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Franco]]></surname>
<given-names><![CDATA[Angélica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quinzaños]]></surname>
<given-names><![CDATA[Jimena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Barragán]]></surname>
<given-names><![CDATA[Marlene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Valadez]]></surname>
<given-names><![CDATA[Erick]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Góngora-Rivera]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suarez Stroke Clinic ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Juárez de México Stroke Clinic ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Instituto Nacional de Rehabilitación Neurorehabilitation Clinic ]]></institution>
<addr-line><![CDATA[Mexico City ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma de Nuevo León Hospital Universitario José Eleuterio González Stroke Unit]]></institution>
<addr-line><![CDATA[Monterrey Nuevo León]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<volume>20</volume>
<numero>5</numero>
<fpage>210</fpage>
<lpage>213</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-50442019000500210&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-50442019000500210&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-50442019000500210&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Although the efficacy of intravenous thrombolysis (IV-T) has been widely demonstrated, the rates of its use continue to be low  Purpose: The purpose of this study was to assess the frequency of IV-T in Mexican hospitals and to describe the target times for acute treatment and the functional evolution of patients  Methods: Data prospectively collected from patients with acute ischemic stroke treated over a period of 2 years in four Mexican hospitals were analyzed. We assessed demographic data, the onset-to-door (OTD) time, the door-to-needle (DTN) time, treatment and the National Institutes of Health Stroke Scale (NIHSS), and modified Rankin scale (mRs) scores at the baseline and at the end of the follow-up  Results: There were 500 patients (mean age 57 ± 14 years, 274 [55%] men). The median OTD time was 11 h (range 30 min-190 h); the mean of NIHSS score was 10 ± 6. Eighty-seven (17.4%) patients arrived at the hospital within 4.5 h; but only 38 (7.6%) patients were treated with IV-T (mean of NIHSS 12 ± 6 points; with a mean OTD time of 2.1 h and a DTN time of 82 ± 51 min). After a median follow-up of 6 months (range 5-24 months), the final NIHSS score was 7 ± 6 points. A better prognosis was observed (mRs &lt; 2) in patients who received IV-T (p = 0.04)  Conclusions: The frequency of IV-T in Mexican hospitals continues to be &lt;10%. A high percentage of patients continues to arrive at the hospital outside the therapeutic window.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Antecedentes y objetivo: Aunque la eficacia de la trombólisis intravenosa (T-IV) está ampliamente probada, las tasas de uso continúan siendo bajas. Nuestro objetivo fue valorar la frecuencia de T-IV en hospitales mexicanos, describir los tiempos meta de tratamiento agudo y la evolución funcional de los pacientes.  Pacientes y métodos: Los datos demográficos, tiempos de llegada al hospital; puerta aguja (TP-A) y el tratamiento empleado de pacientes con infarto cerebral agudo (ICA) y tratados en 4 hospitales mexicanos fueron recolectados en registros prospectivos de enero de 2017 a enero de 2019. La gravedad y discapacidad se midieron por la escala de NIH y la escala modificada de Rankin (emR).  Resultados: Analizamos 500 pacientes (media de edad 57 ± 14 años; 274 (55%) hombres). La mediana de tiempo entre el inicio de los síntomas y la llegada al hospital fue de 11 h (rango de 0.30 a 190 min). La media de NIHSS fue de 10 ± 6 puntos. 38 (7.6%) pacientes recibieron T-IV (media de NIHSS 12 ± 6 puntos). En los tratados con T-IV la media de tiempo del inicio de síntomas a la llegada al hospital fue de 2.1 h (127 min) y el TP-A tuvo una media de 82 ± 51 min. Después del seguimiento el NIHSS final fue de 7 ± 6 puntos. Se observo un mejor pronóstico (emR &lt; 2) en pacientes que recibieron t-IV (p = 0.04).  Conclusiones: La frecuencia de T-IV continúa siendo menor al 10%. Un porcentaje elevado de pacientes continúa llegando al hospital fuera de ventana terapéutica.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Acute ischemic stroke]]></kwd>
<kwd lng="en"><![CDATA[Intravenous thrombolysis]]></kwd>
<kwd lng="en"><![CDATA[t-PA]]></kwd>
<kwd lng="en"><![CDATA[Cerebral infarction]]></kwd>
<kwd lng="en"><![CDATA[Acute]]></kwd>
<kwd lng="es"><![CDATA[Agudo]]></kwd>
<kwd lng="es"><![CDATA[Infarto cerebral]]></kwd>
<kwd lng="es"><![CDATA[Terapia trombolítica]]></kwd>
<kwd lng="es"><![CDATA[t-PA]]></kwd>
<kwd lng="es"><![CDATA[Trombólisis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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