<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1665-1146</journal-id>
<journal-title><![CDATA[Boletín médico del Hospital Infantil de México]]></journal-title>
<abbrev-journal-title><![CDATA[Bol. Med. Hosp. Infant. Mex.]]></abbrev-journal-title>
<issn>1665-1146</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1665-11462025000300008</article-id>
<article-id pub-id-type="doi">10.24875/bmhim.23000142</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Melanoma vulvar en pediatría. Reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Pediatric vulvar melanoma. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Obregón-García]]></surname>
<given-names><![CDATA[Jennifer A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Corzo-Centeno]]></surname>
<given-names><![CDATA[Ángel C.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-López]]></surname>
<given-names><![CDATA[Carolina E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico Nacional, Unidad de Medicina de Alta Especialidad No. 25 Instituto Mexicano del Seguro Social Servicio de Pediatría]]></institution>
<addr-line><![CDATA[Nuevo León ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico Nacional, Unidad de Medicina de Alta Especialidad No. 25 Instituto Mexicano del Seguro Social Servicio de Oncología Pediátrica]]></institution>
<addr-line><![CDATA[Nuevo León ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>82</volume>
<numero>3</numero>
<fpage>191</fpage>
<lpage>194</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1665-11462025000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1665-11462025000300008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1665-11462025000300008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Los melanomas constituyen un pequeño porcentaje de la patología maligna en la piel, pero representan la mayoría de las muertes por cáncer cutáneo. La etiología parece no ser similar a la de otros melanomas donde el factor de riesgo más importante es la exposición a luz ultravioleta. En comparación con los adultos, los melanomas en pediatría tienen una presentación clínica atípica que, aunada a un bajo índice de sospecha, conllevan un retraso en el diagnóstico y un aumento de la mortalidad en esta población.  Caso clínico: Paciente de sexo femenino de 10 años que presenta una lesión hiperpigmentada en la región vulvar izquierda, dolorosa, sin otro síntoma agregado. Es valorada por dermatología, donde describen una neoformación palpable de 5 × 6 mm de diámetro, de color negro y bordes irregulares. A la dermatoscopia se observan asimetría, glóbulos en la periferia, proyecciones irregulares y velo blanco-azul. Posteriormente se realiza biopsia escisional de la lesión, con reporte histopatológico de melanoma HMB45 positivo focal, p53 positivo y Ki-67 focal, con márgenes negativos. Los estudios de extensión sin evidencia de actividad metastásica, por lo que se decide continuar con vigilancia médica por el servicio de oncología pediátrica.  Conclusiones: El melanoma vulvar es una afección maligna de muy baja incidencia en todo el mundo. En México no existen reportes de casos en edad pediátrica. Por su alta mortalidad, la detección temprana y el tratamiento oportuno favorecerán la esperanza de vida de los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Background: Melanomas represent a small percentage of skin malignancies, but they represent the majority of deaths from skin cancer. The etiology of vulvar melanomas may differ from other melanomas, where the most important risk factor is exposure to ultraviolet light. Compared to adults, pediatric melanomas have an atypical clinical presentation, posing as low-suspicion lesions, thus leading to a diagnostic delay and increased mortality in this patient population.  Clinical case: A 10-year-old female with a painful hyperpigmented lesion localized in the left vulvar region, with no other associated symptoms. Dermatology assessment described a palpable neoformation of 5 × 6 mm, black color, with irregular borders. Dermoscopy shown asymmetrical pattern, peripheral globules, irregular projections, and blue-white veil. Subsequently, an excisional biopsy of the lesion was performed, with a histopathological report of melanoma HMB45 positive, p-53 positive and focal Ki-67, negative margins. Further studies revealed no evidence of metastatic activity; therefore, it was decided to continue medical surveillance by the pediatric oncology service.  Conclusions: Vulvar melanoma is a malignant entity with a low incidence rate. There are no case reports published in Mexico that describe its location in the pediatric population. Given the high mortality, early diagnosis and treatment would improve life expectancy in our patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Melanoma]]></kwd>
<kwd lng="es"><![CDATA[Melanoma vulvar]]></kwd>
<kwd lng="es"><![CDATA[Cáncer]]></kwd>
<kwd lng="es"><![CDATA[Pediatría]]></kwd>
<kwd lng="en"><![CDATA[Melanoma]]></kwd>
<kwd lng="en"><![CDATA[Vulvar melanoma]]></kwd>
<kwd lng="en"><![CDATA[Cancer]]></kwd>
<kwd lng="en"><![CDATA[Pediatrics]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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