<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-9940</journal-id>
<journal-title><![CDATA[Archivos de cardiología de México]]></journal-title>
<abbrev-journal-title><![CDATA[Arch. Cardiol. Méx.]]></abbrev-journal-title>
<issn>1405-9940</issn>
<publisher>
<publisher-name><![CDATA[Instituto Nacional de Cardiología Ignacio Chávez]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-99402016000400313</article-id>
<article-id pub-id-type="doi">10.1016/j.acmx.2016.04.002</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comportamiento plasmático y clínico del ácido láctico en el trasplante cardíaco]]></article-title>
<article-title xml:lang="en"><![CDATA[Plasmatic pattern and clinical outcomes of lactic acid in heart transplantation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias]]></surname>
<given-names><![CDATA[Aníbal M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leyendecker]]></surname>
<given-names><![CDATA[Vanina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pizarro]]></surname>
<given-names><![CDATA[Rodolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lucas]]></surname>
<given-names><![CDATA[Luciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vulcano]]></surname>
<given-names><![CDATA[Norberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marenchino]]></surname>
<given-names><![CDATA[Ricardo G.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Castillo]]></surname>
<given-names><![CDATA[Santiago]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cagide]]></surname>
<given-names><![CDATA[Arturo M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Belziti]]></surname>
<given-names><![CDATA[Cesar A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Hospital Italiano de Buenos Aires  ]]></institution>
<addr-line><![CDATA[Buenos Aires ]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="A02">
<institution><![CDATA[,Hospital Italiano de Buenos Aires  ]]></institution>
<addr-line><![CDATA[Buenos Aires ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2016</year>
</pub-date>
<volume>86</volume>
<numero>4</numero>
<fpage>313</fpage>
<lpage>318</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-99402016000400313&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-99402016000400313&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-99402016000400313&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción Hay controversia en relación con el ácido láctico luego del trasplante cardíaco.  Objetivo Evaluar el patrón plasmático del ácido láctico y su valor pronóstico luego del trasplante cardíaco.  Métodos Entre el 2011 y el 2014 se incluyeron 127 pacientes luego de cirugía cardíaca, 71 pertenecieron al grupo trasplante y 56 al grupo "control", conformado por pacientes sometidos a cirugía de revascularización miocárdica. Se compararon los niveles de ácido láctico antes de la cirugía, al ingreso en la Unidad Coronaria, y a las 6, 12 y 24 h en los 2 grupos. Dentro del grupo trasplante se realizó un análisis uni y bivariado entre niveles de ácido láctico y mortalidad hospitalaria.  Resultados La media de edad fue de 57 años. Los niveles de ácido láctico fueron significativamente mayores durante y luego de la cirugía cardíaca en los pacientes del grupo trasplante respecto a los pacientes del grupo control (p&lt;0.001), pero no existieron diferencias significativas en los valores antes de la cirugía (p=0.143; comparaciones no ajustadas). En los trasplantados, los niveles de ácido láctico se asociaron de forma significativa a una mayor mortalidad durante la cirugía, al ingreso, y a las 6, 12 y 24 h. El ácido láctico al ingreso fue un predictor de muerte ajustado por volumen minuto postoperatorio (p=0.011), uso de &#8805; 2 inotrópicos (p=0.033), glucemia al ingreso (p=0.004), edad &#8805; 60 años (p=0.015), tiempo de bomba (p=0.027) y pH (p=0.017).  Conclusiones Los niveles de ácido láctico fueron mayores en los trasplantados y se asociaron a una mayor mortalidad hospitalaria.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction It is not well established the prognostic value of elevated lactic acid after heart transplantation.  Objective To evaluate the plasmatic pattern and the prognostic value of elevated lactate after heart transplantation.  Methods One-hundred and twenty seven patients were included between 2011 and 2014, 71 comprising the transplantation group and 56 the control group, represented by on pump coronary artery by-pass surgery patients. Lactic acid levels were compared between groups before, within and after surgery upon Coronary Care Unit admission, at 6, 12 and 24 h. In addition, in the transplantation group univariate and bivariate analysis were performed between lactic acid levels and in-hospital mortality.  Results The mean age of the entire cohort was 57 years. Among transplanted patients, lactic acid levels were significantly higher over control group: within the surgery; and after surgery (P&lt;.001), but not before surgery (P=.143; unadjusted comparisons). In transplanted patients, lactic acid levels were significantly associated with in-hospital mortality during surgery, at admission, and thereafter but not before surgery. Lactic acid at admission was associated with in-hospital mortality after adjustment of postoperative cardiac output (P=.011), &#8805; 2 inotropic drug support within 24 h (P=.033), glycemic level at admission (P=.004), age &#8805; 60 years (P=.015), on pump time (P=.027), and pH (P=.017).  Conclusions Acid lactic levels were higher in transplanted patients than in the control group and was associated to higher in-hospital mortality.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ácido láctico]]></kwd>
<kwd lng="es"><![CDATA[Insuficiencia cardíaca]]></kwd>
<kwd lng="es"><![CDATA[Trasplante cardíaco]]></kwd>
<kwd lng="es"><![CDATA[Argentina]]></kwd>
<kwd lng="en"><![CDATA[Lactic acid]]></kwd>
<kwd lng="en"><![CDATA[Heart failure]]></kwd>
<kwd lng="en"><![CDATA[Heart transplantation]]></kwd>
<kwd lng="en"><![CDATA[Argentina]]></kwd>
</kwd-group>
</article-meta>
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