<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-888X</journal-id>
<journal-title><![CDATA[TIP. Revista especializada en ciencias químico-biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[TIP]]></abbrev-journal-title>
<issn>1405-888X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Estudios Superiores Zaragoza]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-888X2018000421201</article-id>
<article-id pub-id-type="doi">10.22201/fesz.23958723e.2018.0.156</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de la desnutrición grave en las frecuencias de mutación en el gen Pig-a en reticulocitos y eritrocitos de rata]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of severe malnutrition on mutation frequencies in the Pig-a gene in rat reticulocytes and erythrocytes]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pacheco-Martínez]]></surname>
<given-names><![CDATA[M. Monserrat]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés-Barberena]]></surname>
<given-names><![CDATA[Edith]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Cruz]]></surname>
<given-names><![CDATA[Leonor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz-Muñiz]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma Metropolitana-Iztapalapa Departamento de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Autónoma Metropolitana-Iztapalapa Departamento de Ciencias de la Salud Doctorado en Biología Experimental]]></institution>
<addr-line><![CDATA[ Ciudad de México]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2018</year>
</pub-date>
<volume>21</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-888X2018000421201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-888X2018000421201&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-888X2018000421201&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La asimilación deficiente de alimentos por el organismo conduce a un estado patológico con distintos grados y manifestaciones clínicas, conocido como desnutrición. En los últimos años ha surgido un nuevo ensayo in vivo de detección de mutación somática basado en el gen glucosilfosfatidilinositol de clase A (Pig-a). Este gen es necesario para la síntesis de glicosilfosfatidilinositol (GPI) que une proteínas específicas a la superficie de la célula. Cuando ocurre una mutación en Pig-a, no se puede sintetizar el GPI, ya que, las proteínas no se encuentran en la membrana celular, dando origen al fenotipo GPI negativo, el cual es de fácil detección por medio del análisis con citometría de flujo. En este estudio se utilizó el ensayo Pig-a para examinar el daño génico en ratas desnutridas expuestas al mutágeno N-etil-N-nitrosourea (ENU). Se efectuó el marcaje diferencial de reticulocitos (RET) y eritrocitos (E) de sangre periférica de rata de la cepa Wistar. Se tomó como indicador de daño al material genético de las células, el incremento en las frecuencias de mutantes (FM) Pig-a, que fueron analizadas en un 1 X 106 células, durante 8 semanas. Los resultados muestran que la desnutrición grave por sí misma tiene un efecto dañino sobre la integridad del material genético. La frecuencia de mutantes se incrementó con base en la dosis de ENU y el tiempo de exposición en los grupos con desnutrición (DN).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Poor assimilation of food in the body leads to malnutrition or undernutrition (UN), a pathological condition with varying degrees and clinical manifestations. In recent years, a new test using in vivo somatic mutation detection based on the gene glycosylphosphatidy-linositol Class A (Pig-a) has been developed. This gene is essential for the synthesis of glycosylphosphatidylinositol anchor (GPI) that attaches specific proteins to the cell surface. When a Pig-a mutation takes place, GPI synthesis is blocked; hence, proteins are not found on the cell membrane generating a negative GPI phenotype, which can be easily detected using flow cytometry. The Pig-a assay was used in this study to analyze gene damage in a malnutrition model exposed to mutagen N-ethyl-N-nitrosourea (ENU). The assay was based on a differential staining of reticulocytes (RET) and erythrocytes (E) from peripheral blood of Wistar strain rats. Increased frequencies of mutant (MF) Pig-a, which were analyzed by 1 X 106 cells for 8 weeks, indicated damage to the genetic material of cells. The results demonstrate that UN itself has a deleterious effect on the integrity of genetic material. The MF increased depending on the dose and the time rats were exposed to UN.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[desnutrición]]></kwd>
<kwd lng="es"><![CDATA[reticulocitos]]></kwd>
<kwd lng="es"><![CDATA[eritrocitos]]></kwd>
<kwd lng="es"><![CDATA[ensayo Pig-a]]></kwd>
<kwd lng="es"><![CDATA[mutación génica]]></kwd>
<kwd lng="es"><![CDATA[citometría de flujo]]></kwd>
<kwd lng="en"><![CDATA[malnutrition]]></kwd>
<kwd lng="en"><![CDATA[undernutrition]]></kwd>
<kwd lng="en"><![CDATA[ENU]]></kwd>
<kwd lng="en"><![CDATA[reticulocytes]]></kwd>
<kwd lng="en"><![CDATA[erythrocytes]]></kwd>
<kwd lng="en"><![CDATA[Pig-a assay]]></kwd>
<kwd lng="en"><![CDATA[mutation]]></kwd>
<kwd lng="en"><![CDATA[flow cytometry]]></kwd>
</kwd-group>
</article-meta>
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