<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-5546</journal-id>
<journal-title><![CDATA[Computación y Sistemas]]></journal-title>
<abbrev-journal-title><![CDATA[Comp. y Sist.]]></abbrev-journal-title>
<issn>1405-5546</issn>
<publisher>
<publisher-name><![CDATA[Instituto Politécnico Nacional, Centro de Investigación en Computación]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-55462019000401475</article-id>
<article-id pub-id-type="doi">10.13053/cys-23-4-2986</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Implementación en hardware de un observador no lineal para un modelo matemático de Diabetes Mellitus Tipo 1 (DM1)]]></article-title>
<article-title xml:lang="en"><![CDATA[Hardware Implementation of a Non-Linear Observer for a Diabetes Mellitus Type 1 Mathematical Model]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gamboa L.]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coria]]></surname>
<given-names><![CDATA[Luis N.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas Valdez]]></surname>
<given-names><![CDATA[José R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Villalobos]]></surname>
<given-names><![CDATA[Ramón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valle Trujillo]]></surname>
<given-names><![CDATA[Paul A.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Tecnológico de Tijuana Departamento de Ingeniería Eléctrica y Electrónica ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>4</numero>
<fpage>1475</fpage>
<lpage>1486</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-55462019000401475&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-55462019000401475&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-55462019000401475&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Este trabajo de investigación se estudia un modelo de Diabetes Mellitus tipo 1 (DM1) en el cual se describe la dinámica de las variables de insulina, glucosa y células beta en un sistema no lineal dado por ecuaciones diferenciales ordinarias. Con la finalidad de estimar la glucosa e insulina a partir de las células beta, se diseña un observador de orden reducido, utilizando la teoría de estabilidad de Lyapunov y el teorema de Lasalle. Tanto el modelo matemático DM1 como el observador son implementados en hardware utilizando la tarjeta de desarrollo FPGA Cyclone V de Altera, donde se comprueba la eficiencia del observador diseñado, obteniendo la dinámica del error. De esta forma se aprovechan las bondades de reconfiguración de un FPGA y se demuestra que la evolución de la glucosa en un paciente se puede predecir por medio de un dispositivo embebido de baja potencia, lo cual pretende mejorar la calidad de vida de personas que padecen DM1 que requieren de un muestreo invasivo constante del nivel de células beta en la sangre, buscando que los tratamientos sean determinados con base en esta información.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract This research paper studies a type 1 Diabetes Mellitus (DM1) model in which the dynamics of insulin, glucose and beta cells variables in a non-linear system given by ordinary differential equations are described. In order to estimate glucose and insulin from beta cells, a reduced order observer is designed, using Lyapunov's theory of stability and Lasalle's theorem. Both the DM1 mathematical model and the observer are implemented in hardware using the Altera Cyclone V FPGA development card, where the efficiency of the designed observer is checked, obtaining the dynamics of the error. In this way, the benefits of reconfiguration of an FPGA are used and it is demonstrated that the evolution of glucose in a patient can be predicted by means of a low power embedded device, which aims to improve the quality of life of people suffering from DM1 that require a constant invasive sampling of the level of beta cells in the blood, looking for treatments to be determined based on this information.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Células beta]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus tipo 1]]></kwd>
<kwd lng="es"><![CDATA[FPGA]]></kwd>
<kwd lng="es"><![CDATA[insulina]]></kwd>
<kwd lng="en"><![CDATA[Beta cells]]></kwd>
<kwd lng="en"><![CDATA[type 1 diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[FPGA]]></kwd>
<kwd lng="en"><![CDATA[insulin]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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