<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1405-0099</journal-id>
<journal-title><![CDATA[Cirujano general]]></journal-title>
<abbrev-journal-title><![CDATA[Cir. gen]]></abbrev-journal-title>
<issn>1405-0099</issn>
<publisher>
<publisher-name><![CDATA[Asociación Mexicana de Cirugía General A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1405-00992022000100011</article-id>
<article-id pub-id-type="doi">10.35366/109314</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Papel de Nrf2 y estrés oxidativo en la progresión de esteatohepatitis no alcohólica a hepatocarcinoma]]></article-title>
<article-title xml:lang="en"><![CDATA[Role of Nrf2 and oxidative stress in progression from nonalcoholic steatohepatitis to hepatocarcinoma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Loera-Torres]]></surname>
<given-names><![CDATA[Marco Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cárdenas-Zurita]]></surname>
<given-names><![CDATA[Katya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ríos-García]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cerda-Reyes]]></surname>
<given-names><![CDATA[Eira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales-González]]></surname>
<given-names><![CDATA[José Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central Militar Departamento de Cirugía Hepatopancreatobiliar y Trasplante Hepático ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Central Militar Departamento de Cirugía General ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Central Militar Departamento de Hepatología y Gastroenterología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto Politécnico Nacional Escuela Superior de Medicina Laboratorio de Medicina de Conservación]]></institution>
<addr-line><![CDATA[CDMX ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>44</volume>
<numero>1</numero>
<fpage>11</fpage>
<lpage>17</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S1405-00992022000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S1405-00992022000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S1405-00992022000100011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: El estrés oxidativo y las reacciones de óxido-reducción se encuentran presentes en todos los procesos biológicos. En pacientes con síndrome metabólico, contribuyen al desarrollo de esteatohepatitis no alcohólica, cirrosis y carcinoma hepatocelular, mediante procesos de lipotoxicidad, reclutamiento de citocinas, activación de células estelares, síntesis progresiva de colágena, DAMPs (patrón molecular asociado a lesiones), PAMPs (patrón molecular asociado a patógenos) y daño irreversible al ADN mitocondrial. Nrf2 es el factor de transcripción más importante en la regulación de la expresión de los genes de la respuesta antioxidante enzimática y juega un papel primordial en la respuesta citoprotectora ante la inflamación aguda y en la regeneración hepática. Sin embargo, se ha asociado también al desarrollo de quimiorresistencia y recurrencia tumoral. En este artículo, hacemos una revisión sobre la evidencia existente al respecto.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Oxidative stress and oxide-reduction reactions are present in all biological processes. In patients with metabolic syndrome, they contribute to the development of non-alcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma, through processes of lipotoxicity, cytokine recruitment, activation of stellar cells, progressive synthesis of collagen, DAMPs (Damage-associated molecular pattern), PAMPs (Pathogen-associated molecular pattern molecules) and irreversible damage to mitochondrial DNA. Nrf2 is the most important transcription factor in regulating the expression of enzymatic antioaxidant response genes and plays a major role in the cytoprotective response to acute inflammation and liver regeneration. However, it has also been associated with the development of chemoresistance and tumor recurrence. This article reviews the most recent evidence in this regard.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Nrf2]]></kwd>
<kwd lng="es"><![CDATA[radicales libres]]></kwd>
<kwd lng="es"><![CDATA[estrés oxidativo]]></kwd>
<kwd lng="es"><![CDATA[esteatohepatitis no alcohólica]]></kwd>
<kwd lng="es"><![CDATA[cirrosis hepática]]></kwd>
<kwd lng="es"><![CDATA[hepatocarcinoma]]></kwd>
<kwd lng="en"><![CDATA[Nrf2]]></kwd>
<kwd lng="en"><![CDATA[free radicals]]></kwd>
<kwd lng="en"><![CDATA[oxidative stress]]></kwd>
<kwd lng="en"><![CDATA[non-alcoholic steatohepatitis]]></kwd>
<kwd lng="en"><![CDATA[liver cirrhosis]]></kwd>
<kwd lng="en"><![CDATA[hepatocellular carcinoma]]></kwd>
</kwd-group>
</article-meta>
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