<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0301-696X</journal-id>
<journal-title><![CDATA[Revista de sanidad militar]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. sanid. mil.]]></abbrev-journal-title>
<issn>0301-696X</issn>
<publisher>
<publisher-name><![CDATA[Secretaría de la Defensa Nacional, Dirección General de Sanidad]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0301-696X2018000400324</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aspectos de seguridad en el tratamiento del dolor con analgésicos antiinflamatorios no esteroideos]]></article-title>
<article-title xml:lang="en"><![CDATA[Security issues in pain management with nonsteroidal anti-inflammatory drugs]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Colmenero]]></surname>
<given-names><![CDATA[Irma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Franco]]></surname>
<given-names><![CDATA[Sandra Danahé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zorrilla Mendoza]]></surname>
<given-names><![CDATA[Jazibeth Guadalupe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cortés Chamorro]]></surname>
<given-names><![CDATA[Rebeca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Médico ABC Departamento de Anestesiología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico ABC Departamento de Anestesiología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Médico ABC Departamento de Anestesiología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Nacional Homeopático Departamento de Anestesiología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>72</volume>
<numero>5-6</numero>
<fpage>324</fpage>
<lpage>331</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0301-696X2018000400324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0301-696X2018000400324&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0301-696X2018000400324&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Los antiinflamatorios no esteroideos (AINE) son el grupo farmacológico que más se consume globalmente con o sin prescripción médica, sobre todo para el tratamiento sintomático de diversos padecimientos que cursan con dolor agudo o crónico. La estructura química de los AINE es heterogénea, por lo que comparten efecto antipirético, antiinflamatorio y analgésico a través de su capacidad para inhibir las prostaglandinas proinflamatorias. El conocimiento de que existen múltiples variaciones en cuanto a los perfiles de riesgo que presentan los AINE obliga a individualizar su uso en función de la patología de base, las características particulares del paciente y la experiencia del médico. Los AINE se deben utilizar en ciclos cortos y con las dosis más bajas posibles, tratando de mantenerlos en un rango de eficacia clínica y vigilando en específico las complicaciones gastrointestinales, cardiovasculares, renales, hepáticas y hematológicas derivadas de los mismos. El objetivo de este trabajo es revisar los aspectos de seguridad en el tratamiento analgésico crónico con AINE.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most consumed drugs worldwide, with or without medical prescription, mostly for the symptomatic treatment of a widely range of diseases characterized by acute or chronic pain. NSAIDs have a heterogenous chemical structure that gives them antipyretic, anti-inflammatory and analgesic properties through their ability to inhibit proinflammatory prostaglandins. The variability in risk profiles among NSAIDs forces the medical community to individualize their use based on the personal characteristics of the patients as well as the expertise of the physician. NSAIDs should be used for short cycles of treatment with the lowest doses possible, using them in a range of clinical efficacy, with specific monitoring of gastrointestinal, cardiovascular, renal hepatic and hematologic complications. The objective of this work is to review the safety aspects of the treatment with NSAIDs in chronic analgesic management.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[AINE]]></kwd>
<kwd lng="es"><![CDATA[dolor agudo]]></kwd>
<kwd lng="es"><![CDATA[dolor crónico]]></kwd>
<kwd lng="es"><![CDATA[antiinflamatorios]]></kwd>
<kwd lng="en"><![CDATA[NSAIDS]]></kwd>
<kwd lng="en"><![CDATA[acute pain]]></kwd>
<kwd lng="en"><![CDATA[chronic pain]]></kwd>
<kwd lng="en"><![CDATA[anti-inflammatory agents]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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