<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0300-9041</journal-id>
<journal-title><![CDATA[Ginecología y obstetricia de México]]></journal-title>
<abbrev-journal-title><![CDATA[Ginecol. obstet. Méx.]]></abbrev-journal-title>
<issn>0300-9041</issn>
<publisher>
<publisher-name><![CDATA[Federación Mexicana de Colegios de Obstetricia y Ginecología A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0300-90412019000700006</article-id>
<article-id pub-id-type="doi">10.24245/gom.v87i7.3009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de un gel antiséptico de aplicación intravaginal para pacientes con infecciones cervicovaginales multitratadas]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of an antiseptic gel of intravaginal application for multitreated patients for infectious cervicovaginitis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montesinos-Peña]]></surname>
<given-names><![CDATA[Nardia Eneida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Valencia]]></surname>
<given-names><![CDATA[Marcelino]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado-Enciso]]></surname>
<given-names><![CDATA[Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera-Leal]]></surname>
<given-names><![CDATA[Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paz-Michel]]></surname>
<given-names><![CDATA[Brenda Astrid]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Las Américas Servicio de Ginecología y Obstetricia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Mexicano del Seguro Social Centro Médico Nacional Siglo XXI Unidad de Investigación en Enfermedades Endocrinas]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Servicios de Salud del Estado de Colima Instituto Estatal de Cancerología ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Colima Facultad de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Centro Hospitalario Unión  ]]></institution>
<addr-line><![CDATA[Colima ]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Esteripharma México  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2019</year>
</pub-date>
<volume>87</volume>
<numero>7</numero>
<fpage>454</fpage>
<lpage>466</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0300-90412019000700006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0300-90412019000700006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0300-90412019000700006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  OBJETIVO:  Evaluar la efectividad y seguridad de un gel intravaginal antiséptico, elaborado con agua electrolizada, en el tratamiento de infecciones cervicovaginales bacterianas, fúngicas, parasitarias o mixtas, y en el control de los síntomas típicos en pacientes multitratadas.  MATERIALES y MÉTODOS:  Estudio clínico, comparativo con el tratamiento convencional, de dos brazos, multicéntrico, al azar, con escalamiento de dosis efectuado en pacientes atendidas entre mayo de 2017 y mayo de 2018 en el servicio de Ginecología y Obstetricia del Hospital General de Ecatepec Las Américas, en el Estado de México y en el Centro Hospitalario Unión, de Colima. Grupo control: esquema convencional, antibiótico-antifúngico (7 días); grupos experimentales, gel antiséptico durante 3, 5 o 10 días. Seguimiento del pH vaginal, agente etiológico y síntomas.  RESULTADOS:  Se incluyeron 62 pacientes, con límites de edad de 18 y 42 años, con vaginitis bacteriana en 25 de 62, candidiasis 10 de 62, tricomoniasis 6 de 62 o infección mixta en 21 de 62, multitratadas. La aplicación del gel durante 5 o 10 días erradicó el agente etiológico en 14 de 15 y en 18 de 20 pacientes; con el tratamiento control lo lograron 8 de 14 pacientes (p = 0.021 y 0.030, respectivamente). El gel antiséptico aplicado durante 5 o 10 días fue casi 3 veces más eficaz que el tratamiento control para erradicar el agente infeccioso, eliminar los síntomas y normalizar el pH vaginal.  CONCLUSIONES:  El tratamiento durante 5 o 10 días con el gel antiséptico intravaginal fue casi 3 veces más efectivo que el convencional (antibiótico-antimicótico) en pacientes con cervicovaginitis infecciosa multitratada, útil en la eliminación de los síntomas típicos y bien tolerado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  OBJECTIVE:  To evaluate the efficacy and safety of an intravaginal antiseptic gel, made of electrolyzed water, against bacterial, yeast, parasitic and mixed cervical infections, and to control typical symptoms in multi-treated patients.  MATERIALS AND METHODS:  Clinical study, comparative with conventional treatment, two arms, multicentric, randomized, with dose escalation carried out in patients attended between May 2017 and May 2018 in the gynecology and obstetrics service of the Hospital General de Ecatepec La Américas, in the Estado de Mexico and the Centro Hospitalario Unión, of Colima. Control group: conventional scheme, antibiotic-antifungal (7 days); Experimental groups, antiseptic gel for 3, 5 or 10 days. Monitoring of vaginal pH, etiologic agent and symptoms.  RESULTS:  62 multi-treated patients (18-42 years old) were enrolled, presenting bacterial vaginosis 25/62, yeast infection 10/62, trichomoniasis 6/62 or mixed infection 21/62; bacteria and yeast). Treatment with antiseptic gel during 5 or 10 days eradicated etiological agent, respectively in 14/15 patients and 18/20 patients; control treatment did it in 8/14 patients (p = 0.021, p = 0.026, respectively). Additionally, gel treatment for 5 or 10 days was 3 times more effective than control treatment to eradicate the infection, control symptoms and to normalize vaginal pH.  CONCLUSIONS:  Intravaginal antiseptic gel (5-10 days) was almost 3 times more effective than conventional therapy (antibiotics/antimycotics) against multi-treated cervical infections; as well as useful to control typical symptoms and well tolerated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Antiséptico]]></kwd>
<kwd lng="es"><![CDATA[agua]]></kwd>
<kwd lng="es"><![CDATA[levaduras bacterianas]]></kwd>
<kwd lng="es"><![CDATA[infecciones cervicales mixtas]]></kwd>
<kwd lng="es"><![CDATA[cremas vaginales]]></kwd>
<kwd lng="es"><![CDATA[antibióticos-antifúngicos, tópicos]]></kwd>
<kwd lng="en"><![CDATA[Antiseptic]]></kwd>
<kwd lng="en"><![CDATA[Water]]></kwd>
<kwd lng="en"><![CDATA[Bacterial yeast]]></kwd>
<kwd lng="en"><![CDATA[Mixed cervical infections]]></kwd>
<kwd lng="en"><![CDATA[Vaginal Creams]]></kwd>
<kwd lng="en"><![CDATA[Anti-infective Agents, Local]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>CENETEC</collab>
<article-title xml:lang=""><![CDATA[Prevención, Diagnóstico y Tratamiento de la Vaginitis Infecciosa en Mujeres en Edad Reproductiva en el Primer Nivel de Atención]]></article-title>
<source><![CDATA[Guía de Práctica Clínica IMSS-081-08]]></source>
<year>2014</year>
<publisher-name><![CDATA[Consejo de Salubridad General]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="">
<collab>Faculty of Sexual and Reproductive Healthcare Clinical Guidance</collab>
<source><![CDATA[Management of vaginal discharge in non-genitourinary medicine settings. Clinical Effectiveness Unit. 3. 3. BASHH]]></source>
<year>2012</year>
</nlm-citation>
</ref>
<ref id="B3">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Workowski]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Bolan]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Transmitted Diseases Treatment Guidelines 2015]]></article-title>
<source><![CDATA[MMWR, Recomendations and Reports]]></source>
<year>2015</year>
<volume>64</volume>
<numero>3</numero>
<issue>3</issue>
<publisher-loc><![CDATA[U.S. ]]></publisher-loc>
<publisher-name><![CDATA[Department of Health and Human Services. Centers for Disease Control and Prevention]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medina]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de vaginitis y vaginosis bacteriana en pacientes con flujo vaginal anormal en el Hospital Nacional Arzobispo Loayza]]></article-title>
<source><![CDATA[Rev Med Hered]]></source>
<year>1999</year>
<volume>10</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>144-50</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reynaud]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Infecciones vaginales por cándida: diagnóstico y tratamiento]]></article-title>
<source><![CDATA[Rev Per Ginecol Obstet]]></source>
<year>2007</year>
<volume>53</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>159-66</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sahagún-Cuevas]]></surname>
<given-names><![CDATA[MN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de los gérmenes más frecuentes en pacientes con cervicovaginitis en primer nivel de atención]]></article-title>
<source><![CDATA[Revista Médica]]></source>
<year>2015</year>
<volume>6</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>268-72</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Trejo y Pérez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Guía Clínica para el Diagnóstico, Tratamiento y Prevención de Cervicovaginitis por bacterias, Trichomonas y Candida]]></article-title>
<source><![CDATA[Rev. Med. IMSS]]></source>
<year>2003</year>
<volume>41</volume>
<numero>^sSupl</numero>
<issue>^sSupl</issue>
<supplement>Supl</supplement>
<page-range>S71-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-Ojeda]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Saldaña-González]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Criterios para el diagnóstico de cervicovaginitis aplicados en el primer nivel de atención. Correlación con la Norma Oficial Mexicana]]></article-title>
<source><![CDATA[Rev Med Inst Mex Seguro Soc]]></source>
<year>2007</year>
<volume>45</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>249-54</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Hernández]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cambios en el pH vaginal en pacientes con infección cérvico-vaginal]]></article-title>
<source><![CDATA[Enf Inf Microbiol]]></source>
<year>2013</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>61-5</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Newman]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2015</year>
<volume>10</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López-Hurtado]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalencia de la infección genital por Chlamydia trachomatis en mujeres que asisten al Instituto Nacional de Perinatología de la Ciudad de México]]></article-title>
<source><![CDATA[Revista Chilena Infectol]]></source>
<year>2018</year>
<volume>35</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>371-6</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Menard]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibacterial treatment of bacterial vaginosis: current and emerging therapies]]></article-title>
<source><![CDATA[Int J of Women&#8217;s Health]]></source>
<year>2011</year>
<volume>3</volume>
<numero>295-305</numero>
<issue>295-305</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nagaraja]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antibiotic resistance of Gardnerella vaginalis in recurrent bacterial vaginosis]]></article-title>
<source><![CDATA[Indian J Med Microbiol]]></source>
<year>2008</year>
<volume>26</volume>
<page-range>155-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Karabicak]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Alem]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antifungal susceptibility profiles of Candida species to triazole: application of new CLSI species-specific clinical breakpoints and epidemiological cutoff values for characterization of antifungal resistance]]></article-title>
<source><![CDATA[Mikrobiyol Bul]]></source>
<year>2016</year>
<volume>50</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>122-32</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bautista]]></surname>
<given-names><![CDATA[CT]]></given-names>
</name>
<name>
<surname><![CDATA[Wurapa]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections]]></article-title>
<source><![CDATA[Military Medical Research]]></source>
<year>2016</year>
<volume>3</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1-10</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[Huan]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Characteristics of bacterial vaginosis infection in cervical lesions with risk human papillomavirus infection]]></article-title>
<source><![CDATA[Int J Clin Exp Med]]></source>
<year>2015</year>
<volume>8</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>21080-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torres-Capetillo]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antimicrobial efficacy of neutral super-oxidized electrolyzed gel versus chlorhexidine digluconate 0.12% in biofilm formation on orthodontic mini-implants: An in vitro study]]></article-title>
<source><![CDATA[J Pharmacognosy and Phytotherapy]]></source>
<year>2013</year>
<volume>5</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>64-71</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sosa]]></surname>
<given-names><![CDATA[LO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prótesis faciales retenidas con implantes e imanes: Presentación de tres casos clínicos en pacientes oncológicos]]></article-title>
<source><![CDATA[Cancerología]]></source>
<year>2008</year>
<volume>3</volume>
<page-range>71-6</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cabello-Gutiérrez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efecto de una solución electrolizada de superoxidación con pH neutro sobre la infección del virus de influenza A en células MDCK]]></article-title>
<source><![CDATA[Rev Inst Nal Enf Resp Mex]]></source>
<year>2009</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>280-7</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Paz-García]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Maldonado-Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Días-Reval]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Muñíz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez-Hernández]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sustitución del uso de solución salina fisiológica como irrigante en el manejo de pacientes sépticos y quirúrgicos por solución electrolizada]]></article-title>
<source><![CDATA[Revista Mexicana de Cirugía Bucal y Maxilofacial]]></source>
<year>2011</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>46-52</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Velazquez-Meza]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of the Antimicrobial Activity of a Super Oxidized Solution in Clinical Isolates]]></article-title>
<source><![CDATA[Microbial Drug Resistance]]></source>
<year>2015</year>
<volume>21</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1-6</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-De Jesús]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efficacy and safety of neutral pH superoxidised solution in severe diabetic foot infections]]></article-title>
<source><![CDATA[Int Wound J]]></source>
<year>2007</year>
<volume>4</volume>
<page-range>353-62</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="">
<source><![CDATA[Criterios de Terminología de Eventos Adversos]]></source>
<year>2014</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez-García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluación de la eficacia de ketoconazol 800 mg-clindamicina 100 mg tabletas vaginales, con ketoconazol 800 mg-100 mg de clindamicina cápsulas vaginales en vaginitis candidiásica y vaginosis]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2011</year>
<volume>79</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>75-85</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Georgiev]]></surname>
<given-names><![CDATA[GZ]]></given-names>
</name>
</person-group>
<source><![CDATA[Relative Risk Calculator]]></source>
<year></year>
</nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dover]]></surname>
<given-names><![CDATA[SE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Natural antimicrobials and their role in vaginal health: a short review]]></article-title>
<source><![CDATA[Int J Probiotics Prebiotics]]></source>
<year>2008</year>
<volume>3</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>219-30</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Petricevic]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Witt]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis]]></article-title>
<source><![CDATA[BJOG]]></source>
<year>2008</year>
<volume>115</volume>
<page-range>1369-74</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Verstraelen]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Antiseptics and Disinfectants for the treatment of bacterial vaginosis: A systematic review]]></article-title>
<source><![CDATA[BMC Infectious Diseases]]></source>
<year>2012</year>
<volume>12</volume>
<page-range>148</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Neut]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Topical treatment of infectious vaginitis: effects of antibiotic, antifungal and antiseptic drugs on the growth of normal vaginal Lactobacillus strains]]></article-title>
<source><![CDATA[Open Journal of Obstetrics and Gynecology]]></source>
<year>2015</year>
<volume>5</volume>
<page-range>173-80</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="">
<collab>Office of New Drugs</collab>
<source><![CDATA[Manual of Policies and Procedures. Center for Drug Evaluation and Research]]></source>
<year>2010</year>
<edition>MAPP 6010.3 Rev.1</edition>
</nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Al-Mushrif]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A study of the prevalence of hydrogen peroxide generating Lactobacilli in bacterial vaginosis: the determination of H2O2 concentrations generated, in vitro, by isolated strains and the levels found in vaginal secretions of women with and without infection]]></article-title>
<source><![CDATA[J Obstet Gynaecol]]></source>
<year>1998</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>63-7</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Godínez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparación de la eficacia de la combinación ketoconazol 400 mg + clindamicina 100 mg, con ketoconazol 800 mg + clindamicina 100 mg en vaginitis por Candida y vaginosis bacteriana]]></article-title>
<source><![CDATA[Ginecol Obstet Mex]]></source>
<year>2005</year>
<volume>73</volume>
<page-range>302-7</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez-Hernández]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Infección, erosión y úlceras cérvico-vaginales]]></article-title>
<source><![CDATA[Acta Científica Estudiantil]]></source>
<year>2009</year>
<volume>7</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>254-7</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sellors]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Sankaranarayanan]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<source><![CDATA[Colposcopy and treatment of cervical intraepithelial neoplasia: A Beginners&#8217; Manual]]></source>
<year>2003</year>
<page-range>79-84</page-range><publisher-name><![CDATA[IARC Press]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
