<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0188-6266</journal-id>
<journal-title><![CDATA[Acta universitaria]]></journal-title>
<abbrev-journal-title><![CDATA[Acta univ]]></abbrev-journal-title>
<issn>0188-6266</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Guanajuato, Dirección de Investigación y Posgrado]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0188-62662016000300087</article-id>
<article-id pub-id-type="doi">10.15174/au.2016.1043</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de la eficacia de un irradiador terapéutico para la irradiación de concentrados eritrocitarios, en Oaxaca, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Evaluation of the efficacy of an therapeutic irradiator for irradiation of red cell concentrates, in Oaxaca, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa Luis]]></surname>
<given-names><![CDATA[Sorely Adelina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ochoa Canales]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Matos]]></surname>
<given-names><![CDATA[Ernesto Óscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Osorio]]></surname>
<given-names><![CDATA[Luis Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vargas Arzola]]></surname>
<given-names><![CDATA[Jaime]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilar Ruiz]]></surname>
<given-names><![CDATA[Sergio Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Torres Aguilar]]></surname>
<given-names><![CDATA[Honorio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Autónoma Benito Juárez Facultad de Ciencias Químicas ]]></institution>
<addr-line><![CDATA[ Oaxaca]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Oncología y Radioterapia de Oaxaca  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Estatal de la Transfusión Sanguínea de Oaxaca  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Autónoma Benito Juárez Facultad de Medicina y Cirugía ]]></institution>
<addr-line><![CDATA[ Oaxaca]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2016</year>
</pub-date>
<volume>26</volume>
<numero>3</numero>
<fpage>87</fpage>
<lpage>94</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0188-62662016000300087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0188-62662016000300087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0188-62662016000300087&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La enfermedad injerto contra hospedero asociada a la transfusión (EICH-AT) es una reacción postransfusional grave debido al injerto de linfocitos residuales (LR) presentes en los componentes sanguíneos. El objetivo de este trabajo fue evaluar la eficacia del irradiador terapéutico THERATRON® PhoenixTM (cobalto 60) del Centro de Oncología y Radioterapia de Oaxaca, México, para eliminar la capacidad de proliferación de los LR en concentrados eritrocitarios (CR). Para este fin, se obtuvieron siete concentrados eritrocitarios de donadores de sangre seleccionados según los criterios de las normas oficiales nacionales, los cuales fueron irradiados a 2520 cGy; y se cuantificaron parámetros para evaluar la conservación del potencial terapéutico de los concentrados eritrocitarios (hemoglobina, hematocrito, hemólisis e hiperkalemia) y de efectividad para inactivar a los LR (número, viabilidad y capacidad proliferativa). El irradiador preservó la calidad e incrementó la seguridad transfusional de estos componentes sanguíneos al eliminar la capacidad proliferativa de los LR, y el análisis de costo-efectividad demostró su eficiencia para este proceso. Tomando como base estos resultados, se proponen estos parámetros como control de calidad para la validación de irradiadores terapéuticos y/o de rayos X para la irradiación de concentrados eritrocitarios, así como la difusión de este servicio en todo el país, con la finalidad de reducir la incidencia de la enfermedad injerto contra hospedero asociada a la transfusión.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Transfusion-associated graft versus host disease (TA-GvHD) is a serious transfusion complication due to residual lymphocytes (LR by its acronym in Spanish) engraftment present in blood components. Aim of this project was to evaluate efficacy of therapeutic irradiator THERATRON® PhoenixTM (Cobalt-60) of the Oncology and Radiotherapy Center from Oaxaca, Mexico, to eliminate leukocytes proliferative capability in red cells concentrates. For this end, seven red cell concentrates were obtained from blood donors selected under national standards and they were irradiated at 2520 cGy. Various parameters to evaluate quality maintenance of red cell concentrates (hemoglobin, hematocrit, hemolysis and hyperkalemia), and effectiveness to eliminate lymphocytes proliferative capability (number, viability and lymphocytes proliferation) were quantified. Therapeutic irradiator preserved quality and increased transfusion safety of these blood components by eliminating proliferative capability of residual lymphocytes. Analysis of cost-effectiveness demonstrated its efficiency for this process. Based on these results, parameters are proposed as quality control for validation of therapeutic irradiators or X-ray devices for red cells concentrates irradiation and to spread this service throughout country with aim to reduce incidence of transfusion-associated graft versus host disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Transfusión]]></kwd>
<kwd lng="es"><![CDATA[seguridad sanguínea]]></kwd>
<kwd lng="es"><![CDATA[irradiación de sangre]]></kwd>
<kwd lng="es"><![CDATA[irradiador terapéutico]]></kwd>
<kwd lng="en"><![CDATA[Transfusion]]></kwd>
<kwd lng="en"><![CDATA[blood safety]]></kwd>
<kwd lng="en"><![CDATA[blood irradiation]]></kwd>
<kwd lng="en"><![CDATA[oncologic irradiator]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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