<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0187-893X</journal-id>
<journal-title><![CDATA[Educación química]]></journal-title>
<abbrev-journal-title><![CDATA[Educ. quím]]></abbrev-journal-title>
<issn>0187-893X</issn>
<publisher>
<publisher-name><![CDATA[Universidad Nacional Autónoma de México, Facultad de Química]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0187-893X2020000400086</article-id>
<article-id pub-id-type="doi">10.22201/fq.18708404e.2020.4.75669</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Grids I: Electrophilic Aromatic Substitution]]></article-title>
<article-title xml:lang="es"><![CDATA[Cuadrículas I: Sustitución Electrofílica Aromática]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lamoureux]]></surname>
<given-names><![CDATA[Guy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias-Álvarez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Costa Rica Escuela de Química ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Costa Rica Escuela de Química ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Costa Rica</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>31</volume>
<numero>4</numero>
<fpage>86</fpage>
<lpage>100</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0187-893X2020000400086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0187-893X2020000400086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0187-893X2020000400086&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract The effect of substituents on the reactivity in electrophilic aromatic substitution has been organized in a grid to demonstrate the inductive and resonance effects. This scheme can also incorporate the competition between donation and withdrawal of electron density. In class games are proposed from which undergraduate students can practice the effects while playing.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen El efecto de los sustituyentes en la reactividad de la sustitución electrofílica aromática ha sido organizado en cuadrículas para demostrar los efectos de inducción y resonancia. Este esquema podría incorporar la competencia entre donación y extracción de la densidad electronica. Proponemos actividades en clase, en las cuales los estudiantes pueden practicar los efectos mientras están jugando.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Organic chemistry]]></kwd>
<kwd lng="en"><![CDATA[aromatic electrophilic substitution]]></kwd>
<kwd lng="en"><![CDATA[resonance effects]]></kwd>
<kwd lng="en"><![CDATA[induction effects]]></kwd>
<kwd lng="es"><![CDATA[Química Orgánica]]></kwd>
<kwd lng="es"><![CDATA[sustitución electrofílica aromática]]></kwd>
<kwd lng="es"><![CDATA[efectos de resonancia]]></kwd>
<kwd lng="es"><![CDATA[efectos de inducción]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anslyn]]></surname>
<given-names><![CDATA[E. V.]]></given-names>
</name>
<name>
<surname><![CDATA[Dougherty]]></surname>
<given-names><![CDATA[D. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Modern Physical Organic Chemistry]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Sausalito, CA, USA ]]></publisher-loc>
<publisher-name><![CDATA[University Science Books]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ault]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Activating Effect of Fluorine in Electrophilic Aromatic Substitution]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>1966</year>
<volume>43</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>329-30</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ault]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Electrophilic Aromatic Substitution of Fluorobenzene]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>2004</year>
<volume>81</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>644</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bergwerf]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
</person-group>
<source><![CDATA[]]></source>
<year>2015</year>
</nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Brown]]></surname>
<given-names><![CDATA[H. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Okamoto]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Electrophilic Substituent Constants]]></article-title>
<source><![CDATA[Journal of American Chemical Society]]></source>
<year>1958</year>
<volume>80</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>4979-87</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bruice]]></surname>
<given-names><![CDATA[P. Y.]]></given-names>
</name>
</person-group>
<source><![CDATA[Organic Chemistry 8th ed]]></source>
<year>2016</year>
<edition>8</edition>
<publisher-loc><![CDATA[Upper Saddle River, NJ, USA ]]></publisher-loc>
<publisher-name><![CDATA[Pearson Education]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chaloner]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<source><![CDATA[Organic Chemistry: A Mechanistic Approach]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Boca Raton, USA ]]></publisher-loc>
<publisher-name><![CDATA[CRC Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[D'Amato]]></surname>
<given-names><![CDATA[E. M.]]></given-names>
</name>
<name>
<surname><![CDATA[Börgel]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Ritter]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aromatic C-H Amination in Hexafluoroisopropanol]]></article-title>
<source><![CDATA[Chem. Sci.]]></source>
<year>2019</year>
<volume>10</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>2424-8</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dalvie]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Nair]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Loi]]></surname>
<given-names><![CDATA[C.-M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Metabolism, Pharmacokinetics and Toxicity of Functional Groups: Impact of Chemical Building Blocks on ADMET]]></source>
<year>2010</year>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[The Royal Society of Chemistry]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Finster]]></surname>
<given-names><![CDATA[D. C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Developmental Instruction: Part 1. Perry's Model of Intellectual Development]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>1989</year>
<volume>66</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>659-61</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Forbes]]></surname>
<given-names><![CDATA[D. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Agarwal]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ciza]]></surname>
<given-names><![CDATA[J. L.]]></given-names>
</name>
<name>
<surname><![CDATA[Landry]]></surname>
<given-names><![CDATA[H. A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Zeroing in on Electrophilic Aromatic Substitution]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>2007</year>
<volume>84</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1878-81</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Galabov]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Nikolova]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
<name>
<surname><![CDATA[Ilieva]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Does the Molecular Electrostatic Potential Reflect the Effects of Substituents in Aromatic Systems?]]></article-title>
<source><![CDATA[Chemistry: An European Journal]]></source>
<year>2013</year>
<volume>19</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>5149-55</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gould]]></surname>
<given-names><![CDATA[E. S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Mechanism and Structure in Organic Chemistry, 1st ed]]></source>
<year>1959</year>
<publisher-loc><![CDATA[New York, USA ]]></publisher-loc>
<publisher-name><![CDATA[Holt, Rinehart and Winston, Inc]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Graulich]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Schween]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Concept-oriented Task Design: Making Purposeful Case Comparisons in Organic Chemistry]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>2018</year>
<volume>95</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>376-83</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hansch]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Leo]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Taft]]></surname>
<given-names><![CDATA[R. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Survey of Hammett Substituent Constants and Resonance and Field Parameters]]></article-title>
<source><![CDATA[Chemical Review]]></source>
<year>1991</year>
<volume>91</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>165-95</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Herráez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Hanson]]></surname>
<given-names><![CDATA[R. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Jmol para enseñar y aprender química]]></article-title>
<source><![CDATA[Educación química]]></source>
<year>2017</year>
<volume>22</volume>
<page-range>13-21</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hornback]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
</person-group>
<source><![CDATA[Organic Chemistry, Second Ed]]></source>
<year>2006</year>
<publisher-loc><![CDATA[Belmont, USA ]]></publisher-loc>
<publisher-name><![CDATA[Thomson Brooks/Cole Publishing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McGowens]]></surname>
<given-names><![CDATA[S. I.]]></given-names>
</name>
<name>
<surname><![CDATA[Silversmith]]></surname>
<given-names><![CDATA[E. F.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Organic Reactions Involving Bromine: Puzzles for the Organic Laboratory]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>1998</year>
<volume>75</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1293-4</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Müller]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Glossary of Terms Used in Physical Organic Chemistry (IUPAC Recommendations 1994)]]></article-title>
<source><![CDATA[Pure Applied Chemistry]]></source>
<year>1994</year>
<volume>66</volume>
<page-range>1077-184</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mullins]]></surname>
<given-names><![CDATA[J. J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Six Pillars of Organic Chemistry]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>2008</year>
<volume>85</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>83-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nguyen]]></surname>
<given-names><![CDATA[A. Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Anh]]></surname>
<given-names><![CDATA[N. T.]]></given-names>
</name>
<name>
<surname><![CDATA[Nguyên]]></surname>
<given-names><![CDATA[T. A.]]></given-names>
</name>
</person-group>
<source><![CDATA[Frontier orbitals: A Practical Manual]]></source>
<year>2007</year>
<publisher-loc><![CDATA[West Sussex, UK ]]></publisher-loc>
<publisher-name><![CDATA[John Wiley &amp; Sons]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Palopoli]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreyra]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Conte-Daban]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Richezzi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Foi]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Doctorovich]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Signorella]]></surname>
<given-names><![CDATA[S. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Insights into Second-Sphere Effects on Redox Potentials, Spectroscopic Properties, and Superoxide Dismutase Activity of Manganese Complexes with Schiff-Base Ligands]]></article-title>
<source><![CDATA[ACS Omega]]></source>
<year>2019</year>
<volume>4</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>48-57</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Politzer]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Abrahmsen]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
<name>
<surname><![CDATA[Sjoberg]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of Amino and Nitro Substituents upon the Electrostatic Potential of an Aromatic Ring]]></article-title>
<source><![CDATA[Journal of American Chemical Society]]></source>
<year>1984</year>
<volume>106</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>855-60</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Politzer]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Jayasuriya]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sjoberg]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Laurence]]></surname>
<given-names><![CDATA[P. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Properties of Some Possible Intermediate Stages in the Nitration of Benzene and Toluene]]></article-title>
<source><![CDATA[Journal of American Chemical Society]]></source>
<year>1985</year>
<volume>107</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1174-7</page-range></nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Remya]]></surname>
<given-names><![CDATA[G. S.]]></given-names>
</name>
<name>
<surname><![CDATA[Suresh]]></surname>
<given-names><![CDATA[C. H.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quantification and Classification of Substituent Effects in Organic Chemistry: A Theoretical Molecular Electrostatic Potential Study]]></article-title>
<source><![CDATA[Physical Chemistry Chemical Physics]]></source>
<year>2016</year>
<volume>18</volume>
<numero>30</numero>
<issue>30</issue>
<page-range>20615-26</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Roos]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Roos]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<source><![CDATA[Organic Chemistry Concepts: An EFL Approach]]></source>
<year>2015</year>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rosenthal]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Schuster]]></surname>
<given-names><![CDATA[D. I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Anomalous Reactivity of Fluorobenzene in Electrophilic Aromatic Substitution and Related Phenomena]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>2003</year>
<volume>80</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>679-90</page-range></nlm-citation>
</ref>
<ref id="B28">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Salvatella]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Alkyl Group is a -I +R Substituent]]></article-title>
<source><![CDATA[Educación Química]]></source>
<year>2017</year>
<volume>28</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>232-7</page-range></nlm-citation>
</ref>
<ref id="B29">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Samide]]></surname>
<given-names><![CDATA[M. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[A. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Games, Games, Games; Playing to Engage with Chemistry Concepts]]></article-title>
<source><![CDATA[Chemical Educator]]></source>
<year>2014</year>
<volume>19</volume>
<page-range>167-70</page-range></nlm-citation>
</ref>
<ref id="B30">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shusterman]]></surname>
<given-names><![CDATA[A. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Hoistad]]></surname>
<given-names><![CDATA[L. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Teaching Chemistry with Electron Density Models. 2. Can Atomic Charges Adequately Explain Electrostatic Potential Maps?]]></article-title>
<source><![CDATA[Chemical Educator]]></source>
<year>2001</year>
<volume>6</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>36-40</page-range></nlm-citation>
</ref>
<ref id="B31">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stöver]]></surname>
<given-names><![CDATA[H. D. H.]]></given-names>
</name>
<name>
<surname><![CDATA[Matuszczak]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Willson]]></surname>
<given-names><![CDATA[C. G.]]></given-names>
</name>
<name>
<surname><![CDATA[Fréchet]]></surname>
<given-names><![CDATA[J. M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Design of Polymeric Imaging Materials Based on Electrophilic Aromatic Substitution: Model Studies]]></article-title>
<source><![CDATA[Macromolecules]]></source>
<year>1991</year>
<volume>24</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1741-5</page-range></nlm-citation>
</ref>
<ref id="B32">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tomberg]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Johansson]]></surname>
<given-names><![CDATA[M. J.]]></given-names>
</name>
<name>
<surname><![CDATA[Norrby]]></surname>
<given-names><![CDATA[P.-O.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Predictive Tool for Electrophilic Aromatic Substitutions Using Machine Learning]]></article-title>
<source><![CDATA[Journal of Organic Chemistry]]></source>
<year>2018</year>
<volume>84</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>4695-703</page-range></nlm-citation>
</ref>
<ref id="B33">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tuomisto]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Educational Games in Chemistry Education]]></article-title>
<source><![CDATA[LUMAT-B: Int. J. Math, Sci. Tech. Educ.]]></source>
<year>2016</year>
<volume>1</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-6</page-range></nlm-citation>
</ref>
<ref id="B34">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vollhardt]]></surname>
<given-names><![CDATA[K. P. C.]]></given-names>
</name>
<name>
<surname><![CDATA[Schore]]></surname>
<given-names><![CDATA[N. E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Organic Chemistry: Structure and Function 7th ed]]></source>
<year>2014</year>
<publisher-loc><![CDATA[New York, NY, USA ]]></publisher-loc>
<publisher-name><![CDATA[W.H. Freeman and Company]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B35">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wheeler]]></surname>
<given-names><![CDATA[S. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Understanding Substituent Effects in Noncovalent Interactions Involving Aromatic Rings]]></article-title>
<source><![CDATA[Accounts of Chemical Research]]></source>
<year>2013</year>
<volume>46</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>1029-38</page-range></nlm-citation>
</ref>
<ref id="B36">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zanger]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Gennaro]]></surname>
<given-names><![CDATA[A. R.]]></given-names>
</name>
<name>
<surname><![CDATA[McKee]]></surname>
<given-names><![CDATA[J. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The Aromatic Substitution Game]]></article-title>
<source><![CDATA[Journal of Chemical Education]]></source>
<year>1993</year>
<volume>70</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>985-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
