<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000500572</article-id>
<article-id pub-id-type="doi">10.24245/mim.v33i5.1555</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Utilidad de la eosinopenia como marcador pronóstico de severidad en sepsis]]></article-title>
<article-title xml:lang="en"><![CDATA[Usefulness of eosinopenia as prognostic marker of severity in sepsis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tinoco-Sánchez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suárez-Cuenca]]></surname>
<given-names><![CDATA[JA.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rubio-Guerra]]></surname>
<given-names><![CDATA[AF.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Xoco  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Ticomán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General Ticomán  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>5</numero>
<fpage>572</fpage>
<lpage>579</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000500572&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000500572&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000500572&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  ANTECEDENTES: la sepsis es la causa principal de morbilidad y mortalidad en pacientes críticos, es necesario contar con marcadores pronósticos de severidad que sean cada vez más accesibles y útiles para guiar el tratamiento de manera oportuna. Existe evidencia que demuestra la utilidad de la eosinopenia como marcador pronóstico de severidad. También se ha demostrado que la eosinopenia podría estar asociada con mayor tasa de mortalidad probablemente como consecuencia del entorno inflamatorio sistémico.  OBJETIVO: evaluar la utilidad del recuento bajo de eosinófilos como marcador pronóstico de severidad de sepsis.  MATERIAL Y MÉTODO:  estudio observacional, descriptivo, longitudinal y prospectivo, efectuado en pacientes con diagnóstico de sepsis del Hospital General Xoco. Se determinaron los datos para registro, como edad, sexo, antecedentes de padecimientos crónico-degenerativos, diagnóstico, gravedad clínica del paciente por escala SOFA, y se hizo seguimiento temporal a su ingreso y a las 72 horas; se realizó el recuento de eosinófilos y se obtuvo la media aritmética. Se consideró eosinopenia relativa con valores por debajo de la media de eosinófilos. Posteriormente se realizó una asignación a grupos de acuerdo con la elevación del recuento de eosinófilos después de 72 horas de tratamiento en comparación con su valor inicial.  RESULTADOS: se incluyeron 60 pacientes con estado crítico que requirieron apoyo multiorgánico. La mayoría eran hombres y el promedio de edad fue de 51 años La mayoría de los pacientes (58%) tenía diabetes mellitus. Al comparar el puntaje SOFA del grupo con eosinopenia vs sin eosinopenia se encontraron diferencias significativas, lo que pareciera indicar que la eosinopenia tiene un efecto clínico directo en el estado del paciente; es decir, el grupo con eosinopenia tuvo mayor hipoperfusión tisular o insuficiencia orgánica en comparación con el grupo sin eosinopenia. Se encontró elevación significativa de eosinófilos a las 72 horas.  CONCLUSIONES: la eosinopenia y aumento de eosinófilos después de 72 horas de tratamiento mostraron relación con la modificación de la severidad de la sepsis. Esto sugiere la utilidad de la eosinopenia como factor de predicción de severidad de la sepsis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  BACKGROUND: Sepsis is considered the leading cause of morbidity and mortality in critical patients, it is necessary to have prognostic markers of severity that are increasingly accessible and useful to guide treatment in a timely manner. Evidence demonstrates the usefulness of eosinopenia as a prognostic marker of severity. It has also been shown that eosinopenia may be associated with a higher mortality rate, probably due to the systemic inflammatory environment.  OBJECTIVE: To evaluate the utility of low eosinophil counts as a prognostic marker of sepsis severity.  MATERIAL AND METHOD:  An observational, descriptive, longitudinal and prospective study was done in patients with diagnosis of sepsis of Xoco General Hospital, Mexico City. Data were recorded for registry such as age, sex, chronic-degenerative history, diagnosis, clinical severity of the patient by SOFA scale, and a temporal follow-up was recorded at admission and at 72 h, eosinophil counts and the arithmetic average were performed. Relative eosinopenia was considered with values below the mean of eosinophils. Subsequently, group allocation was performed according to eosinophil count elevation after 72 hours of treatment compared to baseline.  RESULTS: Sixty patients with critical condition requiring multi-organ support were included. The majority were men and the average age was 51 years. Most patients (58%) had diabetes mellitus. When comparing the SOFA score of the group with eosinopenia vs no eosinopenia, significant differences were found, which seems to indicate that the eosinopenia factor has a direct clinical impact on the patient&#8217;s condition, that is, the group with eosinopenia presented greater tissue hypoperfusion or organic failure in comparison with the group without eosinopenia. A significant eosinophil elevation was found at 72 hours.  CONCLUSIONS: Eosinopenia and improvement of eosinophils after 72 hours of treatment were related to the modification of severity of sepsis. This suggests its usefulness of eosinopenia as a predictor of severity of sepsis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[factor pronóstico]]></kwd>
<kwd lng="es"><![CDATA[eosinopenia]]></kwd>
<kwd lng="es"><![CDATA[escala SOFA]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[prognostic factor]]></kwd>
<kwd lng="en"><![CDATA[eosinopenia]]></kwd>
<kwd lng="en"><![CDATA[SOFA]]></kwd>
</kwd-group>
</article-meta>
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