<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0186-4866</journal-id>
<journal-title><![CDATA[Medicina interna de México]]></journal-title>
<abbrev-journal-title><![CDATA[Med. interna Méx.]]></abbrev-journal-title>
<issn>0186-4866</issn>
<publisher>
<publisher-name><![CDATA[Edición y Farmacia S.A. de C.V.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0186-48662017000100099</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actualidades en el tratamiento de la fiebre en el paciente con sepsis y choque séptico: controversias y recomendaciones basadas en evidencia]]></article-title>
<article-title xml:lang="en"><![CDATA[Up-to-date in the management of fever in patients with sepsis and septic shock: controversies and recommendations based on evidence]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero-González]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo-Esper]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meza-Márquez]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sosa-García]]></surname>
<given-names><![CDATA[JO]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Médica Sur  ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Academia Mexicana de Cirugía  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital General de México Unidad de Terapia Intensiva de Infectología ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
</aff>
<aff id="Af4">
<institution><![CDATA[,Secretaría de Salud Centro Nacional de Excelencia Tecnológica en Salud (CENETEC) ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2017</year>
</pub-date>
<volume>33</volume>
<numero>1</numero>
<fpage>99</fpage>
<lpage>108</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0186-48662017000100099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0186-48662017000100099&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0186-48662017000100099&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La fiebre es consecuencia de una respuesta inflamatoria sistémica que puede ser provocada por numerosos estímulos y puede ser un arma de doble filo, debido a que puede tener efectos benéficos, como mejorar la respuesta inmunológica y suprimir el crecimiento bacteriano, pero también tiene efectos dañinos, como aumento de incluso seis veces la tasa metabólica, provocar hiperdinamia, que en pacientes cardiópatas es poco tolerada, e incluso, incrementa el daño pulmonar mediado por citocinas. Por ello, surgen diversas interrogantes acerca de cómo y cuándo debe controlarse la fiebre en el paciente séptico; sin embargo, la evidencia actual es limitada, aunque puede concluirse que el control térmico debe realizarse con temperaturas mayores de 38.5oC con medios físicos y en caso de que no ceda, se sugiere administrar antipiréticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Fever is the result of a systemic inflammatory response that can be triggered by numerous stimuli, which can be a double-edged sword, because it can have beneficial effects, such as improved immune response and suppress bacterial growth, but also harmful effects, such as up to six times higher metabolic rate, causing hyperdynamia that in cardiac patients is poorly tolerated and even increases lung damage mediated by cytokines. Therefore several questions arise about how and when to control fever in septic patient; however, current evidence is limited, but it can be concluded that the thermal control must be performed with temperatures above 38.5oC with physical means and if not, give antipyretics is suggested.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[fiebre]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[paracetamol]]></kwd>
<kwd lng="es"><![CDATA[control térmico]]></kwd>
<kwd lng="en"><![CDATA[fever]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[paracetamol]]></kwd>
<kwd lng="en"><![CDATA[thermal control]]></kwd>
</kwd-group>
</article-meta>
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