<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0035-0052</journal-id>
<journal-title><![CDATA[Revista mexicana de pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. mex. pediatr.]]></abbrev-journal-title>
<issn>0035-0052</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Mexicana de Pediatría A.C.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0035-00522022000100027</article-id>
<article-id pub-id-type="doi">10.35366/106857</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diabetes del adulto de inicio juvenil (diabetes tipo MODY)]]></article-title>
<article-title xml:lang="en"><![CDATA[Maturity-onset diabetes of the young (MODY)]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bobadilla-Olaje]]></surname>
<given-names><![CDATA[Gustavo Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calleja-López]]></surname>
<given-names><![CDATA[Jesús René Tadeo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruibal-Tavares]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivera-Rosas]]></surname>
<given-names><![CDATA[Cristian Noé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilera-Duarte]]></surname>
<given-names><![CDATA[Luis José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Mexicano del Seguro Social (IMSS) Hospital de Gineco-Pediatría &#8220;Dr. Lucio Mayoral Hernández&#8221; ]]></institution>
<addr-line><![CDATA[ Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Sonora Departamento de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Hermosillo Sonora]]></addr-line>
<country>Mexico</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>89</volume>
<numero>1</numero>
<fpage>27</fpage>
<lpage>31</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_arttext&amp;pid=S0035-00522022000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_abstract&amp;pid=S0035-00522022000100027&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://www.scielo.org.mx/scielo.php?script=sci_pdf&amp;pid=S0035-00522022000100027&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen:  Introducción:  La diabetes mellitus tipo MODY (maturity-onset diabetes of the young) comprende un grupo de trastornos genéticos que impiden la función normal de las células beta pancreáticas. Este tipo ocurre entre 1-2% de los casos de diabetes mellitus (DM). El diagnóstico definitivo es por la identificación del gen afectado, sin embargo, por falta de recursos, habitualmente estos pacientes se diagnostican solamente con datos clínicos.  Presentación del caso:  Paciente femenino de 10 años que ingresa a urgencias por infección de vías urinarias, pero dado que se detecta glucemia en 256 mg/dL en ayuno y glucosuria, se realiza el diagnóstico de DM. Meses después la paciente fue tratada como DM MODY debido a antecedentes de diabetes de inicio temprano en familiares de primer grado, así como porque no se detectó resistencia a la insulina, aunado a anticuerpos antiglutamato descarboxilasa (GADA) negativos, reserva pancreática conservada y respuesta adecuada a secretagogos de insulina.  Conclusiones:  La frecuencia de DM MODY probablemente es mayor a la descrita, lo cual se relaciona con la dificultad para disponer de las pruebas genéticas específicas. No obstante, un análisis de los antecedentes familiares, características clínicas y pruebas de laboratorio pueden llevar a un diagnóstico clínico de DM MODY. La detección de este tipo de diabetes permite brindar un tratamiento más adecuado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract:  Introduction:  MODY (maturity-onset diabetes of the young) diabetes mellitus comprises a group of genetic disorders that cause pancreatic beta-cell malfunction. This type of diabetes occurs between 1-2% of all cases of diabetes mellitus (DM). Its definitive diagnosis is by identifying the affected gene, however, due to lack of resources, these patients are usually diagnosed only with clinical data.  Presentation of the case:  A 10-year-old female patient admitted to the emergency department due to a urinary tract infection, but since fasting glucose was detected at 256 mg/dL and glycosuria, a diagnosis of DM was made. Months later, the patient was treated as MODY due to a history of early-onset diabetes in first-degree relatives, because insulin resistance was not detected, anti-glutamate decarboxylase antibodies (GADA) were negative, the pancreatic reserve was preserved, as well as due to adequate response to insulin secretagogues.  Conclusions:  MODY is probably underdiagnosed because it is difficulty to dispose specific genetic tests. However, family history, clinical features, and laboratory tests can lead to a clinical diagnosis of MODY. The detection of this type of diabetes allows to provide a more adequate treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[adolescencia]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[diabetes del adulto de inicio juvenil]]></kwd>
<kwd lng="es"><![CDATA[MODY]]></kwd>
<kwd lng="es"><![CDATA[hiperglucemia]]></kwd>
<kwd lng="en"><![CDATA[adolescence]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus maturity-onset diabetes of the young]]></kwd>
<kwd lng="en"><![CDATA[MODY]]></kwd>
<kwd lng="en"><![CDATA[hyperglycemia]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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